2023
DOI: 10.3389/fneur.2022.1099391
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Utility of serum amyloid A as a potential prognostic biomarker of aneurysmal subarachnoid hemorrhage

Abstract: ObjectivesInflammation plays a vital role in the aneurysmal subarachnoid hemorrhage (aSAH), while serum amyloid A (SAA) has been identified as an inflammatory biomarker. The present study aimed to elucidate the relationship between SAA concentrations and prognosis in aSAH.MethodsFrom prospective analyses of patients admitted to our department between March 2016 and August 2022, aSAH patients with complete medical records were evaluated. Meanwhile, the healthy control group consisted of the age and sex matched … Show more

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Cited by 3 publications
(3 citation statements)
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“…Furthermore, an experimental animal study revealed that the concentration of SAA was notably greater within cerebral ischemia mice, and this concentration had the capability of mediating microglia activation with the use of a gene knockout technique (42). Recently, as revealed by considerable evidence, SAA takes on critical significance in the inflammation of several human diseases (e.g., ischemic stroke receiving endovascular thrombectomy, aSAH, traumatic brain injury, and acute myocardial infarction) (23,28,43,44). Consistent with SAA, CRP refers to an acute phase protein and a well-known marker of inflammation of which peripheral blood concentration indicates the brain's inflammatory response degree and the systemic inflammatory response degree (45)(46)(47).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, an experimental animal study revealed that the concentration of SAA was notably greater within cerebral ischemia mice, and this concentration had the capability of mediating microglia activation with the use of a gene knockout technique (42). Recently, as revealed by considerable evidence, SAA takes on critical significance in the inflammation of several human diseases (e.g., ischemic stroke receiving endovascular thrombectomy, aSAH, traumatic brain injury, and acute myocardial infarction) (23,28,43,44). Consistent with SAA, CRP refers to an acute phase protein and a well-known marker of inflammation of which peripheral blood concentration indicates the brain's inflammatory response degree and the systemic inflammatory response degree (45)(46)(47).…”
Section: Discussionmentioning
confidence: 99%
“…SAA is a useful biomarker for diagnostic confirmation of atherothrombotic ischemic stroke (22). Furthermore, a study carried out recently has confirmed that greater levels of serum SAA, showing a notable relationship to hemorrhagic severity and inflammation, developed an independent relationship with unfavorable results after aneurysmal subarachnoid hemorrhage (23). Additionally, research revealed that risen SAA shows a notable relationship with conditions of inflammation (e.g., myocardial infarction, intracerebral hemorrhage, post-stroke cognitive impairment, and atherosclerosis) (24)(25)(26)(27).…”
Section: Introductionmentioning
confidence: 93%
“…Lipocalin-1/NGAL and serum amyloid A (SAA) are other factors involved in the pathogenesis of the aneurysms. SAA is a protein that correlates with IA wall degeneration, rupture, and increased inflammatory cell infiltration, suggesting its potential role in the pathobiological processes that precede IA rupture [22,23]. Its association with other inflammatory biomarkers indicates SAA's involvement in the development of a more susceptible state for IA rupture, highlighting its significance in understanding this disease [22].…”
Section: Introductionmentioning
confidence: 99%