Utility of serum IgG, IgG4 and carbonic anhydrase II antibodies in distinguishing autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis

Talar-Wojnarowska, Renata; Gąsiorowska, Anita; Dranka-Bojarowska, Daria; Lampe, Paweł; Śmigielski, Jacek; Kujawiak, Magdalena; Grzegorczyk, Janina; Małecka‐Panas, Ewa

doi:10.1016/j.advms.2014.08.003

Cited by 23 publications

(9 citation statements)

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“…Based upon title/abstract reading 1341 articles were not relevant to the topic leading to the full text screening of 41 articles. Ten of these were excluded due to the following reasons (see also Supplementary File S1 ): three studies evaluated markers other than autoantibodies or diagnostic ones [ 10 – 12 ], two studies lacked cancer free controls [ 13 , 14 ], we were unable to calculate sensitivity and specificity in four studies [ 15 – 18 ] and one study did not provide the number of included controls [ 19 ] In the end, with four articles additionally identified through cross-referencing [ 20 – 23 ], 31 articles were included in our review [ 20 – 50 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

2016

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Pancreatic cancer is a leading cause of cancer-related deaths in the western world. Patients with pancreatic cancer have poor prognosis, partly due to difficulties in detecting it at early stages. While different markers have been associated with pancreatic cancer, many of them show suboptimal sensitivity and specificity. Serum autoantibodies against tumor-associated antigens have recently emerged as early stage biomarkers for different types of cancers. Given the urgent need for early and reliable biomarkers for pancreatic cancer, we undertook a systematic review of the published literature to identify primary articles that evaluated serum autoantibodies in pancreatic cancer detection by searching PubMed and ISI Web of Knowledge. Two reviewers extracted data on study characteristics and results independently. Overall, 31 studies evaluating 124 individual serum autoantibodies in pancreatic cancer detection met the inclusion criteria. In general, single autoantibody markers showed relatively low sensitivities at high specificity. A combination of markers, either multiple serum autoantibodies or serum autoantibodies combined with tumor-associated markers, led to a better diagnostic performance. However, most of the analyzed autoantibodies have only been reported in single studies and therefore need to be independently validated. We conclude that serum autoantibodies might present an option as biomarkers for early detection of pancreatic cancer, but more work is needed to identify and validate autoantibody signatures that are associated with early stage pancreatic cancer.

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Section: Resultsmentioning

confidence: 99%

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

2016

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“…For example, significant levels of immunoglobulin (Ig) G antibodies have been detected in cancer patients' plasma, including in pancreatic cancer patients. More specifically, anti-MUC1 serum IgG levels and IgG serum IgG4 concentrations (>135 mg/dL) have been measured in patients with pancreatic cancer (32)(33)(34). In contrast, no data is available for other antibodies such as IgA and IgM in relation with pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

et al. 2020

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Results: Compared to the reference level of 6.10-14.99 g/L, risk of pancreatic cancer was elevated among those with IgG levels <6.10 g/L [HR: 1.69 (95% CI 0.99-2.87)], and an inverse association was observed among those with IgG levels ≥15.00 g/L [0.82 (95% CI 0.64-1.05); Ptrend = 0.027]. The association appeared to be stronger for women than men [HR: 0.64 (95% CI 0.43-0.97) and 0.95 (95% CI 0.69-1.29), respectively]. No associations were observed with IgA or IgM. Conclusion: An inverse association was observed between pre-diagnostic serum levels of IgG and risk of pancreatic cancer. Our findings highlight the need to further investigate the role of immune response in pancreatic cancer etiology.

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“…Nearly 30% of patients undergoing surgery for initially suspected pancreatic cancer turned out as benign pancreatic disease afterwards. Therefore, serological markers such as high IgG4 and CA 19-9 levels as well as the presence of carbonic anhydrase-II antibodies might be helpful diagnostic tools [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience

Buechter

Manka

Heinemann

et al. 2017

Gastroenterology Research and Practice

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Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of patients suffered from AIP1 (55.6%). AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years). Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC). However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4). When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance. Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients. Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC). Conclusion. In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort. AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis.

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Utility of serum IgG, IgG4 and carbonic anhydrase II antibodies in distinguishing autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis

Cited by 23 publications

References 20 publications

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience

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