Utility of SPECT/CT as an Adjunct to Planar Whole Body I-131 Imaging

Abstract

One of the major limitations of planar I-131 imaging is its lack of anatomic precision. SPECT/CT offers the benefit of precise anatomic localization that planar imaging lacks. Whether for confirmation of physiologic uptake or true pathology, SPECT/CT has an important role to play in clarifying equivocal findings. We present a case of papillary thyroid cancer metastatic to the liver, a relatively rare scenario. SPECT/CT allowed definitive lesion characterization at the time of the patient's visit to the nuclear medicine department.

Impact of Indium-111 Oxine Labelling on Viability of Human Mesenchymal Stem Cells In Vitro, and 3D Cell-Tracking Using SPECT/CT In Vivo

“…The hybrid system accurately localized signals through 3D co-registration of images with anatomical and biological information [36,37].…”

Endocrine Scintigraphy with Hybrid SPECT/CT

“…Figure 3. A spectrum of rare metastatic sites depicted on 131 I SPECT/CT has been described (87,88) with reports of metastatic disease in unanticipated tumor locations; eg, liver, kidney, muscle, and trachea (93,(102)(103)(104)(105)(106)(107)(108)(109)(110).…”

Radioiodine Scintigraphy with SPECT/CT: An Important Diagnostic Tool for Thyroid Cancer Staging and Risk Stratification

“…SPECT/CT is an excellent diagnostic tool for rapid evaluation of suspected physiologic mimics and can accurately localize radioiodine distribution to salivary glands, dental fillings, retrosternal goiter, esophageal or airway secretions, hiatal hernias, bowel diverticula, breast, skin contamination, and benign uptake related to radioiodine retention in cysts, bronchiectasis, thymus, benign struma ovarii, or menstruating uterus (53)(54)(55)(56)(57)(58)(59). Several reports outline the usefulness of SPECT/CT for solving difficult diagnostic interpretations and revealing unusual metastatic lesions in the liver, kidney, central nervous system, erector spinae muscle, and rectus abdominis muscle (60)(61)(62)(63)(64).…”