Utility of spectral domain OCT in differentiating optic disc drusen from papilledema in children

Chiu, Houn-Lin; Yang, Francine P.; VandenHoven, Cynthia; Wan, Michael J.

doi:10.1016/j.jcjo.2020.12.003

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…21 Chiu et al found significantly higher RNFL thickness in eyes with papilledema than in eyes with ODD. 22 In other work, Öner et al did not observe an increase in RNFL thickness in the ODD group, but did find that the thickness increased significantly in the IIH group. 20 Similarly, in our study, peripapillary RNFL thickness in the ODD group was similar to the control group in each quadrant.…”

Section: Discussionmentioning

confidence: 85%

Optical coherence tomography angiography findings in optic disc drusen and idiopathic intracranial hypertension

Yalçınkaya

Solmaz

Çakır

et al. 2023

European Journal of Ophthalmology

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Purpose To evaluate the changes in peripapillary microvascularity in idiopathic intracranial hypertension (IIH) and optic disc drusen (ODD) patients, by comparing them with those in healthy individuals, via optical coherence tomography angiography (OCTA). Methods Sixty-two eyes of 33 patients with ODD, 58 eyes of 30 patients with IIH, and 70 eyes of 70 healthy people were imaged for 6 × 6-mm optic disc scans on a spectral-domain OCTA. Vascular densities in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) of ODD, IIH, and healthy eyes were compared with a one-way analysis of variance. Post-hoc analysis was performed with the Gabriel test. Results There was a significant decrease in peripapillary vessel density in SCP, DCP, and CC in patients with IIH compared to the control group ( p < 0.05). In ODD patients, especially peripapillary vessel density in DCP was significantly reduced compared to the control group ( p < 0.05). Peripapillary vessel density in DCP was significantly lower in the IIH group than ODD group ( p < 0.05). Conclusions Peripapillary vascular density may be affected during the course of the disease in both IIH and ODD. Compared to healthy individuals, the decrease in vascular density in these patients and the consequent decrease in perfusion in the peripapillary region may guide the pathogenesis of the complications in the course of these two diseases. Although vascular density in DCP and CC differs significantly between IIH and ODD, case-controlled studies are needed to evaluate the role of OCTA in the differential diagnosis of IHH and ODD.

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Section: Discussionmentioning

confidence: 85%