Utility of Spleen and Liver Cytology in Staging of Canine Mast Cell Tumors

Abstract

Abdominal ultrasound with spleen and liver cytology is part of routine staging for canine mast cell tumors (MCTs). However, such tests are associated with increased morbidity and cost. Therefore, the objectives of this study were to determine if spleen cytology was predictive of liver cytology in canine MCTs and if any patient or tumor variables were associated with spleen and/or liver metastasis. Records of dogs with MCTs and cytology of spleen and liver were reviewed. Two hundred five patients were included. Overall, 22 (10.7%) patients had metastasis, with 21 (10.2%) and 13 (6.3%) having spleen and liver metastasis, respectively, and 12 (5.9%) having both. For patients with a positive (or negative) spleen cytology, the odds ratio of having a positive (or negative) liver cytology was 233.49. However, a negative spleen cytology had a higher predictive value (0.99) than a positive cytology (0.54). Finally, the presence of local and systemic signs and tumor size were associated with spleen, liver, and/or spleen or liver metastasis. These results suggest that spleen cytology is predictive of liver cytology in staging of canine MCTs, and increasing tumor size and presence of local or systemic signs are associated with an increased risk of visceral metastasis.

WSAVAguidelines for the control of reproduction in dogs and cats

“…The tumour is considered non-invasive and does not cause metastases (Devereaux & Schoolmeester, 2019). Recurrence after surgical removal is significantly decreased after gonadectomy (Herron, 1983;Kydd & Burnie, 1986;Thacher & Bradley, 1983). Leiomyomas may spontaneously regress after OHE (Kydd & Burnie, 1986;Sathya & Linn, 2014;Ferré-Dolcet et al 2020b).…”

Presencia de mastocitoma en el pabellón auricular en un canino

“…Es común observarlas como masas únicas, pudiendo ser de un carácter más agresivo, siendo entre el 20 y 50% de los casos (6). El 6.3% de los caninos pueden llegar a presentar mastocitoma como un tumor primario en la zona gastrointestinal, hígado y bazo (7).…”