Utility of superior mesenteric artery Doppler and maternal pancreatic size for predicting gestational diabetes mellitus

Tosun, Alptekin; Duzguner, Soner; Özkaya, Enis; Korkmaz, Vakkaş; Acar, Sezer; Gültekin, Bahadır; Altınboğa, Orhan; Duzguner, Ipek Nur Balin; Küçüközkan, Tuncay

doi:10.1007/s11845-014-1155-7

Cited by 2 publications

(3 citation statements)

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“…Ten studies investigated pancreas diameters in the setting of diabetes mellitus. Three of them included separate T1DM and T2DM cohorts (Ohno et al, ; Gilbeau et al, ; Silva et al, ), three included only T1DM cohorts (Brunova et al, ; Valean et al, ; Altobelli et al, ), one a gestational diabetes mellitus (GDM) cohort (Tosun et al, ), one a mature onset diabetes of the young type 8 (MODY‐8) cohort (Raeder et al, ), one separate cohorts of diabetes of the exocrine pancreas (DEP), MODY (type unspecified), and T1DM (Mohan et al, ), and one a mixed T1DM and T2DM cohort (Basiratnia et al, ) (Table ).…”

Section: Resultsmentioning

confidence: 99%

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Quantitative determination of pancreas size using anatomical landmarks and its clinical relevance: A systematic literature review

et al. 2018

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There have been many reports of altered pancreas size in diseases of the endocrine and exocrine pancreas, but few attempts to quantify such changes. The aim of this study was to conduct a systematic literature review, documenting the methodology, and quantitative data in studies reporting on pancreas size. Three electronic databases (Embase, Scopus, and MEDLINE) were searched by two reviewers independently. Studies of humans were included if they compared pancreas size (reported as pancreas diameters, areas, and/or lengths) between diseased populations and controls. A total of 28 studies with 3,810 individuals were included. Among these, 22 measured pancreas diameters, seven measured pancreas areas, and one measured pancreas lengths. The most common landmark for the head of the pancreas was the confluence of the superior mesenteric and splenic veins (three out of nine studies, 33.3%); for the body it was the superior mesenteric artery (seven out of nine, 77.8%); for the tail it was the internal border of the left kidney (two out of six, 33.3%). Pancreas diameters and areas tended to be smaller in diabetes mellitus, the extent of reduction being greater in individuals with type 1 than type 2 diabetes. Pancreas diameters tended to be greater in acute pancreatitis and pancreatic cancer but not in chronic pancreatitis. Pancreas diameters are a clinically relevant measure for diseases of the endocrine and exocrine pancreas. Consensus guidelines need to be developed to standardize their measurements. Clin. Anat. 31:913-926, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 99%

“…The other three diseases in the diabetes mellitus spectrum that were covered were DEP (Mohan et al, ), GDM (Tosun et al, ), and MODY (Mohan et al, ; Raeder et al, ). The results of these studies are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

Quantitative determination of pancreas size using anatomical landmarks and its clinical relevance: A systematic literature review

et al. 2018

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“…An increase in mean subcutaneous adipose thickness was found in GDM by both D’ambrosi [ 106 ] and Kansu-Celik [ 108 ]. Among the cardiovascular features, Tosun et al [ 109 ] report significant differences in the superior mesenteric artery doppler systolic/diastolic ratio and the resistance index in GDM women, both increased. Isovolumic relaxation time (IRT) was reported by Nar et al and Aguilera et al as significantly higher (75–80.8 vs 68–71.6 ms [ 51 , 110 ] ( n = 773).…”

Section: Main Textmentioning

confidence: 99%

The diagnostic indicators of gestational diabetes mellitus from second trimester to birth: a systematic review

Filippo

Wanniarachchi

Wei

et al. 2021

Clin Diabetes Endocrinol

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Background Gestational diabetes mellitus (GDM) is glucose intolerance first recognised during pregnancy. Both modalities and thresholds of the GDM diagnostic test, the Oral Glucose Tolerance Test (OGTT), have varied widely over time and among countries. Additionally, OGTT limitations include inconsistency, poor patient tolerability, and questionable diagnostic reliability. Many biological parameters have been reported to be modified by GDM and could potentially be used as diagnostic indicators. This study aimed to 1) systematically explore biomarkers reported in the literature as differentiating GDM from healthy pregnancies 2) screen those indicators assessed against OGTT to propose OGTT alternatives. Main body A systematic review of GDM diagnostic indicators was performed according to PRISMA guidelines (PROSPERO registration CRD42020145499). Inclusion criteria were full-text, comprehensible English-language articles published January 2009-January 2021, where a biomarker (from blood, ultrasound, amniotic fluid, placenta) was compared between GDM and normal glucose tolerance (NGT) women from the second trimester onward to immediately postpartum. GDM diagnostic method had to be clearly specified, and the number of patients per study higher than 30 in total or 15 per group. Results were synthesised by biomarkers. Results Of 13,133 studies identified in initial screening, 174 studies (135,801 participants) were included. One hundred and twenty-nine studies described blood analytes, one amniotic fluid analytes, 27 ultrasound features, 17 post-natal features. Among the biomarkers evaluated in exploratory studies, Adiponectin, AFABP, Betatrophin, CRP, Cystatin-C, Delta-Neutrophil Index, GGT, TNF-A were those demonstrating statistically and clinically significant differences in substantial cohorts of patients (> 500). Regarding biomarkers assessed versus OGTT (i.e. potential OGTT alternatives) most promising were Leptin > 48.5 ng/ml, Ficolin3/adiponectin ratio ≥ 1.06, Chemerin/FABP > 0.71, and Ultrasound Gestational Diabetes Score > 4. These all demonstrated sensitivity and specificity > 80% in adequate sample sizes (> / = 100). Conclusions Numerous biomarkers may differentiate GDM from normoglycaemic pregnancy. Given the limitations of the OGTT and the lack of a gold standard for GDM diagnosis, advanced phase studies are needed to triangulate the most promising biomarkers. Further studies are also recommended to assess the sensitivity and specificity of promising biomarkers not yet assessed against OGTT. Trial registration PROSPERO registration number CRD42020145499.

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Utility of superior mesenteric artery Doppler and maternal pancreatic size for predicting gestational diabetes mellitus

Abstract: Superior mesenteric artery Doppler and pancreatic size evaluation may be utilized to detect abnormal glucose metabolism during pregnancy care.

Cited by 2 publications

References 20 publications

Quantitative determination of pancreas size using anatomical landmarks and its clinical relevance: A systematic literature review

Quantitative determination of pancreas size using anatomical landmarks and its clinical relevance: A systematic literature review

The diagnostic indicators of gestational diabetes mellitus from second trimester to birth: a systematic review

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