Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism

Deepak, Gupta; Saini, Jitender; Kesavadas, Chandrasekharan; Sarma, P. Sankara; Kishore, Asha

doi:10.1007/s00234-010-0677-6

Cited by 115 publications

(105 citation statements)

References 39 publications

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“…Our results are in concordance with several previous studies reporting increased iron depositions in the SN of patients with multiple system atrophy and IPD. 15,[42][43][44][45][46][47] A few studies [48][49][50] used SWI images to detect putative iron content in the brain as a tool to differentiate MSA-P from IPD. Gupta et al 49 investigated SWI for patterns of mineralization to differentiate progressive supranuclear palsy, IPD, and multiple system atrophy; minimum-intensity-projection images of SWI were used to obtain signal intensities of each nucleus, which did not demonstrate a significant difference between IPD and multiple system atrophy, though higher putaminal hypointensity scores were found in patients with multiple system atrophy compared with those with IPD.…”

Section: Discussionmentioning

confidence: 99%

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Wang¹,

Butros²,

Shuai³

et al. 2011

AJNR Am J Neuroradiol

136

122

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Section: Discussionmentioning

confidence: 99%

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Wang¹,

Butros²,

Shuai³

et al. 2011

AJNR Am J Neuroradiol

136

122

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“…10 In addition to the sensitivity of SWI to paramagnetic material, corrected phase images that are calculated to form final SWI can provide quantitative phase-shift values that reflect tissue iron content. 11 Recently published studies attempted to use SWI to differentiate movement disorders, including MSA-p, 12 and demonstrated different iron-deposition patterns between MSA-p and IPD by measuring phase-shift values by using corrected phase images of SWI sequences. 13 However, most previous studies regarding SWI were performed on 1.5T or weaker main magnetic field MR imaging machines.…”

Section: Abbreviationsmentioning

confidence: 99%

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Hwang¹,

Sohn

Kang³

et al. 2015

AJNR Am J Neuroradiol

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“…102 The potential advantages of SWI in DBS and Gamma Knife radiosurgery, among other procedures, have led to a significant number of studies further examining the role of SWI in applications for functional neurosurgery. 1,14,22,39,43,44,55,66,74,80,91,103,106,116 Fig. 10.…”

Section: Swi In Functional Neurosurgerymentioning

confidence: 99%

Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives

Ieva¹,

Lam²,

Alcaide‐Leon

et al. 2015

JNS

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T he initial development of MR venography by Reichenbach et al. 90 laid the foundation for Haacke et al. 42 to apply the principles of MR venography in conventional MRI for broader usage in clinical and research settings. By utilizing magnitude and phase information, both of which are normally acquired from conventional MRI data, susceptibility weighted imaging (SWI) has an enhanced ability to detect microhemorrhages 4,12,26 and microvasculature. 26,27,41,92 It is a highly sensitive imaging modality able to depict magnetic substances, such as deoxygenated hemoglobin, with high contrast 42 and to help investigate neurological diseases, 82 grade tumors, 25,63 and assist in determining treatment or prognosis. 18,26,37,70,71,115 Over the past years, the SWI technique has found applications in the different fields of neurosurgery, namely neurooncology, vascular neurosurgery, neurotraumatolabbreviatioNs AVM = arteriovenous malformation; CCM = cerebral cavernous malformation; CMB = cerebral microbleed; CVS = cortical vessel sign; DAI = diffuse axonal injury; DBS = deep brain stimulation; DWI = diffusion-weighted imaging; GBM = glioblastoma multiforme; GCS = Glasgow Coma Scale; GPe = external globus pallidus; GPi = internal GP; GRE = gradient-recalled echo; ITSS = intratumoral susceptibility signal; mIP = minimum intensity projection; MRA = MR angiography; MS = multiple sclerosis; PD = proton density; PQ = percentagewise quantification; PWI = perfusion-weighted imaging; SN = substantia nigra; STN = subthalamic nucleus; SWI = susceptibility weighted imaging; TBI = traumatic brain injury; VM = vascular malformation. Susceptibility weighted imaging (SWI) is a relatively new imaging technique. Its high sensitivity to hemorrhagic components and ability to depict microvasculature by means of susceptibility effects within the veins allow for the accurate detection, grading, and monitoring of brain tumors. This imaging modality can also detect changes in blood flow to monitor stroke recovery and reveal specific subtypes of vascular malformations. In addition, small punctate lesions can be demonstrated with SWI, suggesting diffuse axonal injury, and the location of these lesions can help predict neurological outcome in patients. This imaging technique is also beneficial for applications in functional neurosurgery given its ability to clearly depict and differentiate deep midbrain nuclei and close submillimeter veins, both of which are necessary for presurgical planning of deep brain stimulation. By exploiting the magnetic susceptibilities of substances within the body, such as deoxyhemoglobin, calcium, and iron, SWI can clearly visualize the vasculature and hemorrhagic components even without the use of contrast agents. The high sensitivity of SWI relative to other imaging techniques in showing tumor vasculature and microhemorrhages suggests that it is an effective imaging modality that provides additional information not shown using conventional MRI. Despite SWI's clinical advantages, its implementation in MRI protocols is st...

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Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism

Abstract: SWI shows different patterns of brain mineralization in clinically diagnosed groups of PD, PSP, and MSA-P and may be considered as an additional MR protocol to help differentiate these conditions.

Cited by 115 publications

References 39 publications

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives

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