Utility of Tc-99m GSA SPECT Imaging in Estimation of Functional Volume of Liver Segments in Health and Liver Diseases

Imaeda, T; Kanematsu, Masayuki; Asada, Shuichi; Seki, Matsuzo; Doi, Hidetaka; Saji, Shigetoyo

doi:10.1097/00003072-199504000-00008

Cited by 30 publications

(21 citation statements)

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Section: ;25:828-832)mentioning

confidence: 99%

“…Liver function in cancer-bearing segments tends to be de-tions, with the progression of chronic liver disease, the L/ R ratio of counts per unit hepatic volume was significantly creased when compared with that of noncancerous segments 5 ; therefore, we selected patients without space-occu-elevated (Fig. 3), suggesting that the effect of disease on hepatic functional reserve per unit hepatic volume is not unipying lesions in the liver on CT images.…”

Section: Aid Hepa 0025mentioning

confidence: 99%

“…the size of the right hepatic lobe with enlargement of the Before the Tc-99m GSA imaging, subjects underwent conventional left hepatic lobe in patients with cirrhosis. in each lobe, 5,6 it remains unclear how these measures change The severity of liver disease was quantified by the Pugh modifiedin each lobe in cirrhosis, or how they correlate with typical Child-Turcotte criteria.14 Of the 28 patients with chronic liver dismorphological changes of cirrhosis.ease, 4 had chronic hepatitis (3 men and 1 woman; average age, 65Technetium-99m-diethylenetriaminepentaacetic acid-ga-years; range, 53 to 71 years), 8 with cirrhosis were classified as class lactosyl-human serum albumin (Tc-99m GSA), 7-9 a compound A (6 men and 2 women; average age, 58 years; range, 40 to 76 years;CTCS, 5 or 6), 10 with cirrhosis were classified as class B (9 men similar to Tc-99m-galactosyl-neoglycoalbumin, 10-13 is an anaand 1 woman; average age, 57 years; range, 44 to 77 years; CTCS, log ligand of the asialoglycoprotein and binds specifically to 7-9), and 6 with cirrhosis were designated as class C (5 men using a triple-head gamma camera (PRISM 3000 SPECT Imaging Received March 4, 1996; accepted December 27, 1996. System, Ohio Imaging, Picker International, Bedford Heights, OH) Address reprint requests to: Sakae Matsuzaki, M.D., First Department of Surgery, Nipequipped with a low-energy, general purpose parallel-hole collimator pon Medical School, 1-1-5 Sendagi, Tokyo 113, interfaced to a computer (ODYSSEY, Ohio Imaging, Picker Interna-…”

mentioning

confidence: 99%

“…in each lobe, 5,6 it remains unclear how these measures change The severity of liver disease was quantified by the Pugh modifiedin each lobe in cirrhosis, or how they correlate with typical Child-Turcotte criteria.…”

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Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

et al. 1997

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SAKAE MATSUZAKI, MASAHIKO ONDA, TAKASHI TAJIRI, AND DEOG Y. KIM mammalian hepatocytes. The indices obtained from We studied the hepatic functional reserve in the lobes GSA planar imaging correlate with conventional indicators of the liver in 28 patients with chronic liver disease and for hepatic functional reserve, eg, serum albumin level, pro-13 controls using single photon emission computed tothrombin time, indocyanine green retention rate at 15 minmography (SPECT) imaging with a radiolabeled asialoutes, indocyanine green disappearance rate, and Pugh modiglycoprotein analog, Technetium-99m-diethylenetrified-Child-Turcotte criteria score (CTCS). aminepentaacetic acid-galactosyl-human serumThe purpose of this study was to document changes in the albumin (Tc-99m GSA). Counts of Tc-99m GSA radioachepatic functional reserve of the right and left hepatic lobes tivity in the liver on SPECT images significantly correwith the progression of chronic liver disease, using computed lated (P õ .0001) with the serum albumin level (r Å tomography (CT) and Tc-99m GSA single photon emission .612), log (serum cholinesterase activity) (r Å .618), secomputed tomography (SPECT), and to determine whether rum bilirubin level (r Å .628), prothrombin time (r Å changes in imaging modalities reflect the hepatic morphologi-.715), hepaplastin test (r Å .637), and indocyanine cal changes in cirrhosis. Å .491, P Å .0019) significantly. These findings suggest All controls were normal on physical examination and results of liver that the reduction of hepatic functional reserve per function tests, including alanine transaminase, aspartate transamiunit hepatic volume and numerical density of the he-nase, bilirubin, and alkaline phosphatase were normal. The subjects patocytes, and the proliferation of fibrosis in patients included 13 controls (7 men and 6 women; average age, 59 years; with chronic liver disease is slower in the left lobe than range, 36 to 76 years) and 28 patients with chronic liver disease.The patients with chronic liver disease were diagnosed on the basis of in the right. We discuss a possible biological basis for physical findings, ultrasound findings, CT findings, and biochemical these apparent lobar differences and for hepatic mor- 1997;25:828-832.)Of the 28 patients with chronic liver disease, 5 were caused by alcohol and 23 were caused by viral hepatitis. Because hepatic morphological Previous studies have documented a relative reduction in changes in cirrhosis are not pathognomonic for a specific cause, 4 all of the patients with chronic liver disease underwent a full evaluation. the size of the right hepatic lobe with enlargement of the Before the Tc-99m GSA imaging, subjects underwent conventional left hepatic lobe in patients with cirrhosis. in each lobe, 5,6 it remains unclear how these measures change The severity of liver disease was quantified by the Pugh modifiedin each lobe in cirrhosis, or how they correlate with typical Child-Turcotte criteria.14 Of the 28 patients with chronic liver dismorphological changes ...

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Section: ;25:828-832)mentioning

confidence: 99%

Section: Aid Hepa 0025mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

et al. 1997

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“…In a group of patients with diverse underlying liver pathologies investigated with 99m Tc-mebrofenin, it was found that liver function was unevenly distributed within the liver [11]. Regional variations in uptake were also demonstrated using 99m Tc-labelled galactosyl human serum albumin [12,13]. This phenomenon was also observed in patients with primary sclerosing cholangitis using 99m Tc-HIDA [14].…”

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confidence: 82%