Utility of umbilical cord blood 25-hydroxyvitamin D levels for predicting bronchopulmonary dysplasia in preterm infants with very low and extremely low birth weight

Yu, Haoting; Fu, Jianhua; Feng, Yong

doi:10.3389/fped.2022.956952

Cited by 4 publications

(4 citation statements)

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“…The main limitation of this study is the absence of determination of 25(OH)D at birth; some infants from both groups may have experienced an early deficiency in 25(OH)D, which is a recognized risk factor for BPD [4,6], and they may not be equally distributed be-tween groups, decreasing the difference between groups for the primary outcome. Despite this limitation, these results are important because they show that in the absence of an early determination of 25(OHD), a 25(OH)D concentration above 120 nmol/L before 36 weeks corrected age is not a significant risk factor for BPD or death.…”

Section: Discussionmentioning

confidence: 99%

“…Further studies are necessary to determine the appropriate modalities of administration of native vitamin D in extremely and very preterm infants as it is a modifiable factor that could impact the risk of BPD [4,6] and the risk of sepsis [45][46][47][48], two essential factors for the future of premature infants, but also nephrological and bone-related outcomes. The prevention of vitamin D deficiency at birth and the effectiveness of treatment with native vitamin D in infants with depleted and normal levels at birth should be evaluated with a careful monitoring of respiratory and infectious outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Low concentrations of 25-Hydroxyvitamin D (25(OH)D) at birth and at one month of age have been associated with increased risk of BPD as demonstrated by a meta-analysis [4] and a study adjusting for the factors known to be associated with BPD [5]. Furthermore, low 25(OH)D at one month Nutrients 2023, 15, 4423 2 of 10 of age has also been associated with increased risk of bronchopulmonary dysplasia [6]. However, studies investigating high-dose supplementation (compared with low-dose) failed to demonstrate any significant effect on the frequency of BPD [7,8] but have found high 25(OH)D concentrations in the groups exposed to high doses [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?

Laborie,

Bonjour,

Bacchetta

et al. 2023

Nutrients

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Low 25-Hydroxyvitamin D (25(OH)D) in preterm infants is a risk factor for bronchopulmonary dysplasia (BPD), but increased supplementation failed to demonstrate a beneficial effect on BPD. In neonatal animal models, deficiency and excessive vitamin D exposure have been associated with increased mortality and histological alterations in the lung evocative of BPD. Our hypothesis is that 25(OH)D levels ≥ 120 nmol/L are also a risk factor for BPD or death. This retrospective single-center cohort study included only infants born at <31 weeks gestational age without major malformations with at least a determination of 25(OH)D at <36 weeks corrected age and no determination <50 nmol/L. Routine 25(OH)D determination was performed at 1 month and monthly thereafter. A total of 175 infants were included. Infants with BPD or who died had a significantly lower term and weight, but a similar frequency of 25(OH)D ≥120 nmol/L (50.5% vs. 43.9%, p = 0.53). The logistic regression identified weight (OR 0.997, 95% CI [0.995–0.998]) and term (OR 0.737, 95% CI [0.551–0.975]) as significantly associated with BPD or death; the occurrence of excessive 25(OH)D was not significantly associated (OR 1.029, 95% CI [0.503–2.093]). The present study did not demonstrate any significant association between excessive 25(OH)D after one month of age and BPD or death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?

Laborie,

Bonjour,

Bacchetta

et al. 2023

Nutrients

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“…The vitamin D and E levels were shown to be inversely linked with the period of oxygen support required for preterm newborns with BPD [ 50 ]. A retrospective research revealed that a 25-hydroxy vitamin D level of 15.7 ng·mL −1 in the UCB was predictive of BPD development (AUC=0.585, 95% CI: 0.523–0.645, p=0.016) [ 51 ]. The positive predictive value was 57.1%, whereas the negative predictive value was 63.3%.…”

Section: Biofluid Biomarkersmentioning

confidence: 99%

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

Cui

2023

ERJ Open Res

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Despite remarkable breakthroughs in diagnosis and treatment, the prevalence of bronchopulmonary dysplasia (BPD) in preterm infants and the consequent mortality have remained high over the last half-century. The pathophysiology of BPD is complicated, with several causes. In addition, infants with severe BPD are predisposed to a variety of complications that need multidisciplinary collaboration during hospitalisation and post-discharge home treatment. Consequently, early prediction, precise prevention, and individualised management have become the cornerstones of therapeutic care of preterm infants with BPD, thereby improving patient survival and prognosis. BPD has an operational clinical description; however, it has various clinical phenotypes and endotypes, making accurate prediction challenging. Currently, most approaches for predicting BPD in preterm infants include invasive collection of biofluids, which is inappropriate in fragile neonates. Consequently, researchers and clinicians are becoming more interested in noninvasive monitoring for BPD prediction. Comprehensive assessments of pertinent research, however, remain scarce. In this review, we compared many noninvasive monitoring techniques that contribute to early prediction of BPD development in premature infants.

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Predictive value of Vitamin D levels in pregnant women on gestational length and neonatal weight in China: a population-based retrospective study

Chen,

Chu,

Liu

et al. 2024

Reprod Biol Endocrinol

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Background Vitamin D deficiency, a common occurrence among pregnant women, is an emerging public health concern worldwide. According to research, prenatal vitamin D deficiency is associated with various complications. This study assessed the vitamin D status of pregnant women in Yanbian, Jilin Province, as well as the correlation and predictive value of their vitamin D levels in relation to gestational length (weeks) and fetal weight, aiming to provide a basis for clinical diagnosis and treatment. Methods We conducted a population-based retrospective study involving 510 pregnant women from August 2019 to October 2022. Blood samples were collected at 16–20 weeks of gestation for the detection of serum vitamin D levels. Statistical analyses were performed using SPSS 28.0 and R 4.1.0 software. Multifactorial logistic regression analysis was employed to establish whether each variable was a risk factor for deliveries at ≤ 38 gestational weeks and low fetal weight. These results were used to construct a risk prediction model, and the model’s predictive efficacy was evaluated. Results or differences with p < 0.05 were considered statistically significant. Results Multifactorial logistic regression analysis revealed that vitamin D ≤ 14.7 ng/mL(OR: 1.611; 95% CI: 1.120–2.318; P = 0.010), Bone Mineral Density (BMD) T-value ≤-1(OR: 1.540; 95%CI: 1.067–2.223; P = 0.021), and gestational hypertension(OR: 7.173; 95% CI: 1.482–34.724; P = 0.014) were the independent risk factors for deliveries at ≤ 38 gestational weeks. Additionally, vitamin D ≤ 14.7 ng/mL(OR: 1.610; 95%CI: 1.123–2.307; P = 0.009), BMD T-value ≤ -1(OR: 1.560; 95%CI: 1.085–2.243; P = 0.016), and gestational hypertension(OR: 4.262; 95% CI: 1.058–17.167; P = 0.041) were the independent risk factors for low fetal weight (< 3400 g). Conclusion This study revealed that low vitamin D levels are an independent risk factor for a short gestational length and low fetal weight. Prenatal low BMD T-value and comorbid hypertensive disorders were also found to increase the risk of a short gestational length and low fetal weight.

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Utility of umbilical cord blood 25-hydroxyvitamin D levels for predicting bronchopulmonary dysplasia in preterm infants with very low and extremely low birth weight

Cited by 4 publications

References 53 publications

Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?

Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

Predictive value of Vitamin D levels in pregnant women on gestational length and neonatal weight in China: a population-based retrospective study

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