Utilization and clinical outcomes of kidney transplants from deceased donors with albuminuria in the UK: a national cohort study

Abstract

Background Urinalysis is a standard component of potential deceased kidney donor assessment in the UK. The value of albuminuria as a biomarker for organ quality is uncertain. We examined the relationship between deceased donor albuminuria and kidney utilisation, survival, and function. Methods We performed a national cohort study on adult deceased donors and kidney transplant recipients between 2016 and 2020, using data from the UK Transplant Registry. We examined the influence of donor albuminuria, defined as ≥ 2 + on dipstick testing, on kidney utilisation, early graft function, graft failure, and estimated glomerular filtration rate (eGFR). Results Eighteen % (1681/9309) of consented donors had albuminuria. After adjustment for confounders, kidneys from donors with albuminuria were less likely to be accepted for transplantation (74% vs 82%; OR 0.70, 95% CI 0.61 to 0.81). Of 9834 kidney transplants included in our study, 1550 (16%) came from donors with albuminuria. After a median follow-up of 2 years, 8% (118/1550) and 9% (706/8284) of transplants from donors with and without albuminuria failed, respectively. There was no association between donor albuminuria and graft failure (HR 0.91, 95% CI 0.74 to 1.11). There was also no association with delayed graft function, patient survival, or eGFR at 1 or 3 years. Conclusions Our study suggests reluctance in the UK to utilise kidneys from deceased donors with dipstick albuminuria but no evidence of an association with graft survival or function. This may represent a potential to expand organ utilisation without negatively impacting transplant outcomes.

Beyond donation to organ utilization in the UK

“…A central repository of UK publications on the issues has been collated by one of the authors (MI), organized by organ type, and published on the NHSBT website [41]. NHSBT has also provided funding for research fellows to examine utilization-related issues within UK organ transplantation, such as the use of older deceased donor kidneys [19], outcomes of kidneys transplanted after previous offer declines [42 ▪ ], effect of donor proteinuria on graft utilization and outcomes [43], and risks of disease transmission [44 ▪ ,45].…”