Utilization and Effectiveness of Desmopressin Acetate After Cardiac Surgery Supplemented With Point-of-Care Hemostatic Testing: A Propensity-Score–Matched Analysis

Orlov, David; McCluskey, Stuart A.; Callum, Jeannie; Rao, Vivek; Moreno, J Ruiz; Karkouti, Keyvan

doi:10.1053/j.jvca.2016.11.022

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…31 AWB is part of the authors' routine blood conservation technique and generally is effective in reducing allogeneic transfusion rates. 47 Use of 1-deamino-8-D-arginine vasopressin (DDAVP) in post-CPB coagulopathy remains controversial, 48 and previous clinical experiences have failed to support the efficacy of DDAVP to improve platelet aggregability in the presence of ticagrelor. 34,41 However, it is possible that DDAVP may augment thrombin generation by elevating factor VIII and affect platelet aggregability via thrombin receptors (protease-activated receptors) on platelet surfaces.…”

Section: Discussionmentioning

confidence: 99%

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Williams

Henderson

Reformato

et al. 2020

Journal of Cardiothoracic and Vascular Anesthesia

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Section: Discussionmentioning

confidence: 99%

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Williams

Henderson

Reformato

et al. 2020

Journal of Cardiothoracic and Vascular Anesthesia

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“…However, there is currently a paucity of quality data to support the routine use of point-of-care platelet function testing in predicting bleeding risk in cardiac surgical patients. Despite an increased use of desmopressin (DDAVP) for bleeding related to platelet dysfunction [61], evidence for its efficacy remains limited.…”

Section: Recent Advancesmentioning

confidence: 99%

Advances in critical care management of patients undergoing cardiac surgery

et al. 2018

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Cardiac surgery has been evolving to include minimally invasive, hybrid and transcatheter techniques. Increasing patient age and medical complexity means that critical care management needs to adapt and evolve. Recent advances have occurred in several areas, including ventilation, haemodynamics and mechanical circulatory support, bleeding and coagulation, acute kidney injury, and neurological management. This narrative review describes standard care, recent advances, and future areas of research in the critical care management of patients undergoing cardiac surgery.

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“…Whole blood platelet function tests obtained after CPB often demonstrate abnormal aggregation patterns using various agonists on Multiplate®, TEG® Platelet Mapping™ or Plateletworks® (Helena, Beaumont, TX, USA) [4647596061]. Only a portion of those who demonstrate a below-normal platelet function require actual platelet transfusion [4659].…”

Section: Effects Of Cardiopulmonary Bypass On Platelet Function Testsmentioning

confidence: 99%

Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y₁₂inhibitors

Mazzeffi

Lee

Taylor

et al. 2017

Korean J Anesthesiol

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Platelets play pivotal roles in hemostasis as well as pathological arterial thrombosis. The combination of aspirin and a P2Y12 inhibitor has become the mainstay therapy in the ageing population with cardiovascular conditions, particularly during and after percutaneous coronary intervention. A number of novel P2Y12 inhibitors has become available in the recent years, and they markedly vary in pharmacokinetic and pharmacodynamic properties. Perioperative physicians today face a challenge of preventing hemorrhage due to platelet inhibitors, while minimizing thrombotic risks. There are several point-of-care platelet function tests available in the peri-procedural assessment of residual platelet aggregation. However, these platelet function tests are not standardized in terms of sample processing, agonist type and potency as well as methods of detecting platelet activity. Understanding the differences in pharmacological properties of antiplatelet agents, principles of platelet function tests, and pertinent hemostatic strategies may be useful to anesthesiologists and intensivists who manage perioperative issues associated with antiplatelet agents. The objectives of this review are: 1) to discuss clinical data on aspirin and P2Y12 inhibitors relating to perioperative bleeding, 2) to outline different features of point-of-care platelet function tests, and 3) to discuss therapeutic options for the prevention and treatment of bleeding associated with antiplatelet agents.

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Utilization and Effectiveness of Desmopressin Acetate After Cardiac Surgery Supplemented With Point-of-Care Hemostatic Testing: A Propensity-Score–Matched Analysis

Cited by 6 publications

References 53 publications

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Advances in critical care management of patients undergoing cardiac surgery

Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y₁₂inhibitors

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Utilization and Effectiveness of Desmopressin Acetate After Cardiac Surgery Supplemented With Point-of-Care Hemostatic Testing: A Propensity-Score–Matched Analysis

Cited by 6 publications

References 53 publications

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading

Advances in critical care management of patients undergoing cardiac surgery

Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12inhibitors

Contact Info

Product

Resources

About

Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y₁₂inhibitors