The current study looks at the effectiveness of the removal of nickel (II) from aqueous solution using an adsorption method in a laboratory-size reactor.An artificial neural network (ANN) and an adaptive neuro-fuzzy inference system (ANFIS) were used in this study to predict blend hydrogels adsorption potential in the removal of nickel (II) from aqueous solution. Four operational variables, including initial Ni (II) concentration (mg/L), pH, contact duration (min), and adsorbent dose (mg/L), were used as an input with removal percentage (%) as the only output; they were studied to assess their impact on the adsorption study in the ANFIS model. In contrast, 70% of the data was used for training, while 15% of the data was used in testing and validation to build the ANN model. Feedforward propagation with the Levenberg-Marquardt algorithm was employed to train the network. The use of ANN and ANFIS models for experiments was used to optimize, construct, and develop prediction models for Ni (II) adsorption using blend hydrogels. The adsorption isotherm and kinetic models were also used to describe the process. The results show that ANN and ANFIS models are promising prediction approaches that can be applied to successfully predict metal ions adsorption. According to this finding, the root mean square errors (RMSE), absolute average relative errors (AARE), average relative errors (ARE), mean squared deviation (MSE), and R 2 for Ni (II) in the training dataset were 0.061, 0.078, 0.017, 0.019, and 0.986, respectively, for ANN. In the ANFIS model, the RMSE, AARE, ARE, MSE, and R 2 were 0.0129, 0.0119, 0.028, 0.030, and 0.995, respectively. The adsorption process was spontaneous and well explained by the Langmuir model, and chemisorption was the primary control. The morphology, functional groups, thermal characteristics, and crystallinity of blend hydrogels were all assessed.