Utilization of Aloe Compounds in Combatting Viral Diseases

Abstract

Plants contain underutilized resources of compounds that can be employed to combat viral diseases. Aloe vera (L.) Burm. f. (syn. Aloe barbadensis Mill.) has a long history of use in traditional medicine, and A. vera extracts have been reported to possess a huge breadth of pharmacological activities. Here, we discuss the potential of A. vera compounds as antivirals and immunomodulators for the treatment of viral diseases. In particular, we highlight the use of aloe emodin and acemannan as lead compounds that should be considered for further development in the management and prevention of viral diseases. Given the immunomodulatory capacity of A. vera compounds, especially those found in Aloe gel, we also put forward the idea that these compounds should be considered as adjuvants for viral vaccines. Lastly, we present some of the current limitations to the clinical applications of compounds from Aloe, especially from A. vera.

Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

“…The results showed that aloe vera gel provided better results than CHX [ 80 ]. These studies have highlighted the mechanisms of action of aloe vera which has the following: Anti-inflammatory properties thanks to the content of acemannans and anthraquinones which can reduce inflammation by acting on inflammatory processes at a cellular level [ 103 ]; Antioxidant properties thanks to the presence of vitamins C and E and flavonoids which protect cells from damage caused by free radicals [ 51 , 104 ]; Antimicrobial action preventing infections and helping to maintain oral hygiene [ 80 , 105 ]; Effects on bacterial plaque, influencing its growth and formation [ 106 ]; Effects on the immune system by helping to regulate the immune response and reduce inflammation [ 107 ]; Positive effects on wound healing by stimulating collagen production especially in the presence of small wounds or irritations caused by orthodontic devices [ 108 , 109 ]; Hydrating and soothing effects on skin and oral mucous membranes, improving patient comfort and reducing irritation [ 110 , 111 ]. …”

“…Hydrating and soothing effects on skin and oral mucous membranes, improving patient comfort and reducing irritation [ 110 , 111 ].…”

A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application

“…Aloe compounds have the potential to be used as antiviral drugs and immunomodulators to treat viral diseases, especially the use of emodin and AC in aloe as lead compounds [ 71 ]. Infection with human immunodeficiency virus (HIV) may cause organ failure and tumor development throughout the body, which is a serious threat to life and health.…”

Enhancing effects of Aloe vera gel extracts on the humoral and cellular immune response and growth performance in broiler chickens

“…A neutraceutical combination of AV, Poria cocos, and rosemary extract triggered the activation markers on various types of innate immune cells, resulting in enhanced immune surveillance and antioxidant defense [ 14 ]. In C57BL/6 mice, processed AV gel given orally functions as an adjuvant for influenza vaccinations [ 15 – 17 ]. Alprogen and Aloe polysaccharides play a role in modulating the immune system and specifically have antiallergic effects [ 18 ].…”