Utilization of DSC for Pharmaceutical crystal form quantitation

Vitéz, I

doi:10.1023/b:jtan.0000042151.60566.0f

Cited by 27 publications

(8 citation statements)

References 40 publications

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“…The 100% amorphous standard is prepared in situ in the DSC. The amorphous content in a given sample can then be estimated either from the heat of crystallization22,63 or enthalpy of fusion23,64,65 of the sample using the following equation 66 Where, Δ H is the enthalpy of fusion of the sample and Δ H 0 is that of the 100% crystalline standard.…”

Section: Quantification Techniquesmentioning

confidence: 99%

Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids

Shah

Kakumanu

Bansal

2006

Journal of Pharmaceutical Sciences

329

235

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Section: Quantification Techniquesmentioning

confidence: 99%

Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids

Shah

Kakumanu

Bansal

2006

Journal of Pharmaceutical Sciences

329

235

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“…The amount of crystalline drug can be calculated on the basis of the melting enthalpy of the drug [ 48 ]. Here, a simplified method was used [ 49 , 50 ] to calculate the amount of crystalline drug in FCC-Nif and D5N20 formulations:

where

is the amount of crystalline drug,

is the melting enthalpy of the drug-loaded formulation, and

is the melting enthalpy of the drug in bulk nifedipine.…”

Section: Methodsmentioning

confidence: 99%

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

et al. 2020

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Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues. Proliposomes are one of the formulation approaches for achieving solid powders that readily form liposomes upon hydration. In this work, we investigated a dry powder formulation of a model low-soluble drug with phospholipids loaded in porous functionalized calcium carbonate microparticles. We characterized the liposome formation under conditions that mimic the different gastrointestinal stages and studied the factors that influence the dissolution rate of the model drug. The liposomes that formed upon direct contact with the simulated gastric environment had a capacity to directly encapsulate 25% of the drug in situ. The emerged liposomes allowed complete dissolution of the drug within 15 min. We identified a negative correlation between the phospholipid content and the rate of water uptake. This correlation corroborated the results obtained for the rate of dissolution and liposome encapsulation efficiency. This approach allows for the development of solid proliposomal dosage formulations, which can be scaled up with regular processes.

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“…Books and reviews dealing with the principles, instrumentation and applications are given in references [3][4][5][6][7][8][9][10]. Specific applications of thermal analysis and calorimetric methods for pharmaceutical polymorphism are given in references [11][12][13][14][15][16][17][18][19].…”

Section: Thermal Analysis Methodsmentioning

confidence: 99%

Thermal Analysis and Calorimetric Methods Applied to Pharmaceutical Solid Forms

Giron¹

2012

Physico-Chemical Methods in Drug Discovery and Development

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Utilization of DSC for Pharmaceutical crystal form quantitation

Cited by 27 publications

References 40 publications

Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids

Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Thermal Analysis and Calorimetric Methods Applied to Pharmaceutical Solid Forms

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