Utilization of exogenous siderophores by Campylobacter species

Baig, B H; Wachsmuth, I K; Morris, G K

doi:10.1128/jcm.23.3.431-433.1986

Cited by 32 publications

(12 citation statements)

References 25 publications

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“…It is also possible that the fag genes are responsible for the uptake of a siderophore which is not produced by C. pseudotuberculosis, but which C. pseudotuberculosis can scavenge in vivo, from other bacteria. This latter scenario is observed with organisms such as Campylobacter species [20] and may be supported by the lack of siderophore biosynthetic genes clustered with the fag genes.…”

Section: Utilization Of Iron Sources By a C Pseudotuberculosis Fagb(mentioning

confidence: 77%

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

Billington¹

2002

FEMS Microbiology Letters

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Four genes, fagA, B, C and D, encoding products with 32^47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the Corynebacterium pseudotuberculosis phospholipase D gene. L-Galactosidase assays on a C. pseudotuberculosis strain carrying a fagA-lacZ fusion indicated that the putative fagABC operon was poorly expressed in iron-rich media. However, similar experiments in iron-limited media resulted in an approximately three-fold increase in L-galactosidase activity, suggesting that this operon is regulated by iron in vitro. Although no defect in iron utilization could be determined for a C. pseudotuberculosis fagB(C) mutant in vitro, this mutant showed reduced virulence compared to wild-type in a goat model of caseous lymphadenitis. Thus, expression of the fag genes in the host appears to contribute to virulence. ß

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Section: Utilization Of Iron Sources By a C Pseudotuberculosis Fagb(mentioning

confidence: 77%

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

Billington¹

2002

FEMS Microbiology Letters

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“…They, however, cannot synthesise ferrioxamines themselves, but may be available from related species and other members of normal gut microbiota (Champomier-Verges et al, 1996;Kingsley et al, 1999). Examples of other genera that can utilise heterologous siderophores are Campylobacter and Pseudomonas (Baig et al, 1986;Champomier-Verges et al, 1996;Llamas et al, 2006). A study with microbial isolates from marine sediments indicated that the growth of many bacteria depends on siderophore production by other bacteria within the same community (D'Onofrio et al, 2010).…”

Section: Iron Cross-feeding With Heterologous Siderophoresmentioning

confidence: 99%

Nutritional iron turned inside out: intestinal stress from a gut microbial perspective

et al. 2014

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Iron is abundantly present on earth, essential for most microorganisms and crucial for human health. Human iron deficiency that is nevertheless highly prevalent in developing regions of the world can be effectively treated by oral iron administration. Accumulating evidence indicates that excess of unabsorbed iron that enters the colonic lumen causes unwanted side effects at the intestinal host-microbiota interface. The chemical properties of iron, the luminal environment and host iron withdrawal mechanisms, especially during inflammation, can turn the intestine in a rather stressful milieu. Certain pathogenic enteric bacteria can, however, deal with this stress at the expense of other members of the gut microbiota, while their virulence also seems to be stimulated in an iron-rich intestinal environment. This review covers the multifaceted aspects of nutritional iron stress with respect to growth, composition, metabolism and pathogenicity of the gut microbiota in relation to human health. We aim to present an unpreceded view on the dynamic effects and impact of oral iron administration on intestinal host-microbiota interactions to provide leads for future research and other applications.

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“…Neisseria gonorrhoeae for example uses aerobactin [172], as does the Gram positive organism Corynebacterium diphtheriae [173]. Haemophilus influenzae, H. parainfluenzae and H. paraphrophilus [174], Pseudomonas aeruginosa [175] and Campylobacter jejuni [176,177] can all utilise enterochelin.…”

Section: Siderophore Systems In Other Bacteriamentioning

confidence: 99%

Iron uptake mechanisms of pathogenic bacteria

Wooldridge

Williams

1993

FEMS Microbiology Reviews

390

245

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Most of the iron in a mammalian body is complexed with various proteins. Moreover, in response to infection, iron availability is reduced in both extracellular and intracellular compartments. Bacteria need iron for growth and successful bacterial pathogens have therefore evolved to compete successfully for iron in the highly iron-stressed environment of the host's tissues and body fluids. Several strategies have been identified among pathogenic bacteria, including reduction of ferric to ferrous iron, occupation of intracellular niches, utilisation of host iron compounds, and production of siderophores. While direct evidence that high affinity mechanisms for iron acquisition function as bacterial virulence determinants has been provided in only a small number of cases, it is likely that many if not all such systems play a central role in the pathogenesis of infection.

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Utilization of exogenous siderophores by Campylobacter species

Cited by 32 publications

References 25 publications

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

Nutritional iron turned inside out: intestinal stress from a gut microbial perspective

Iron uptake mechanisms of pathogenic bacteria

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