Utilization of inulin-containing waste in industrial fermentations to produce biofuels and bio-based chemicals

Hughes, Stephen R.; Qureshi, Nasib; López-Núñez, Juan Carlos; Jones, Marjorie A.; Jarodsky, Joshua M.; Galindo-Leva, Luz Ángela; Lindquist, Mitchell R.

doi:10.1007/s11274-017-2241-6

Cited by 37 publications

(18 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…K. marxianus is also distinguished by thermotolerance (Lane et al, 2011 ), and the fastest reported growth rate of any eukaryote (Groeneveld et al, 2009 ). Recent years have seen increasing interest in new applications such as production of biomolecules (Hughes et al, 2017 ; Lin et al, 2017 ), biocatalysis (Oliveira et al, 2017 ; Wang et al, 2017 ) and heterologous protein production (Gombert et al, 2016 ; Lee et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates

et al. 2018

View full text Add to dashboard Cite

Kluyveromyces marxianus is traditionally associated with fermented dairy products, but can also be isolated from diverse non-dairy environments. Because of thermotolerance, rapid growth and other traits, many different strains are being developed for food and industrial applications but there is, as yet, little understanding of the genetic diversity or population genetics of this species. K. marxianus shows a high level of phenotypic variation but the only phenotype that has been clearly linked to a genetic polymorphism is lactose utilisation, which is controlled by variation in the LAC12 gene. The genomes of several strains have been sequenced in recent years and, in this study, we sequenced a further nine strains from different origins. Analysis of the Single Nucleotide Polymorphisms (SNPs) in 14 strains was carried out to examine genome structure and genetic diversity. SNP diversity in K. marxianus is relatively high, with up to 3% DNA sequence divergence between alleles. It was found that the isolates include haploid, diploid, and triploid strains, as shown by both SNP analysis and flow cytometry. Diploids and triploids contain long genomic tracts showing loss of heterozygosity (LOH). All six isolates from dairy environments were diploid or triploid, whereas 6 out 7 isolates from non-dairy environment were haploid. This also correlated with the presence of functional LAC12 alleles only in dairy haplotypes. The diploids were hybrids between a non-dairy and a dairy haplotype, whereas triploids included three copies of a dairy haplotype.

show abstract

Section: Introductionmentioning

confidence: 99%

Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Inulin is a polysaccharide commonly found in roots, tubers, and plant rhizomes from common foods, including asparagus, chicory, garlic, onion, and artichoke [ 43 ]. A 2014 meta-analysis [ 44 ] of randomized controlled clinical trials involving two hundred and fifty-two subjects (four adult studies and one pediatric study that was included in this review) found that inulin improved stool frequency, stool consistency, and transit time.…”

Section: Resultsmentioning

confidence: 99%

The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

Axelrod

Saps

2018

Nutrients

View full text Add to dashboard Cite

We reviewed the available evidence on the role of fiber in the treatment of Functional Constipation (FC) and Irritable Bowel Syndrome (IBS) in children. The vast majority of toddlers and preschoolers do not consume enough fiber. Two of the most common reasons for consultation to a pediatric gastroenterology practice include FC and IBS. The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines state that the evidence does not support the use of fiber supplements in the treatment of FC in children, and the Rome IV criteria do not recommend an increase in fiber consumption, in children with IBS. Despite this, in general practice, it is commonly recommended that children who experience constipation and IBS to increase their fiber intake. We conducted a systematic review of the available evidence on the role of fiber in the treatment of FC and IBS in children. Thirteen full-text articles with a total of seven hundred and twenty-three pediatric participants were included in this review. Three clinical trials found positive effects of dietary fiber for the management of IBS. Nine out of ten trials found fiber to be either more effective than placebo, or just as effective as laxative treatment. Most studies on the use of fiber for the treatment of FC and IBS have shown its benefit. However, due to the heterogeneity in study design, length of treatment, outcome measures, and amount and type of fiber, we were unable to make a definitive recommendation supporting the use of fiber for the treatment of FC and IBS in children.

show abstract

“…It was first isolated and characterized by the German scientist, Valenti Rose, in 1804 from the roots of flowering plant Inula helenum [85]. Inulin can be found in roots of chicory ( Cichorium endivia ), Jerusalem artichoke ( Helianthus tuberosus ), or blue agave ( Agave tequilana ), where it accumulates as a means of energy storage [86]. Inulin, together with oligofructose, is a fructan, a sub-class of carbohydrate characterized by fructosyl–fructose links between monomers.…”

Section: Alternative Saccharidesmentioning

confidence: 99%

Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses

2019

View full text Add to dashboard Cite

Non-conventional yeasts are efficient cell factories for the synthesis of value-added compounds such as recombinant proteins, intracellular metabolites, and/or metabolic by-products. Most bioprocess, however, are still designed to use pure, ideal sugars, especially glucose. In the quest for the development of more sustainable processes amid concerns over the future availability of resources for the ever-growing global population, the utilization of organic wastes or industrial by-products as feedstocks to support cell growth is a crucial approach. Indeed, vast amounts of industrial and commercial waste simultaneously represent an environmental burden and an important reservoir for recyclable or reusable material. These alternative feedstocks can provide microbial cell factories with the required metabolic building blocks and energy to synthesize value-added compounds, further representing a potential means of reduction of process costs as well. This review highlights recent strategies in this regard, encompassing knowledge on catabolic pathways and metabolic engineering solutions developed to endow cells with the required metabolic capabilities, and the connection of these to the synthesis of value-added compounds. This review focuses primarily, but not exclusively, on Yarrowia lipolytica as a yeast cell factory, owing to its broad range of naturally metabolizable carbon sources, together with its popularity as a non-conventional yeast.

show abstract

Utilization of inulin-containing waste in industrial fermentations to produce biofuels and bio-based chemicals

Cited by 37 publications

References 52 publications

Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates

Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates

The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses

Contact Info

Product

Resources

About