Utilization of low-temperature helium plasma (J-Plasma) for dissection and hemostasis during carotid endarterectomy

Filis, Konstantinos; Galyfos, George; Sigala, Fragiska; Zografos, Georgios

doi:10.1016/j.jvscit.2020.01.008

Cited by 3 publications

(5 citation statements)

References 21 publications

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“…In our department, the Plastic Surgery Division of the University Hospital of Modena, we have experienced various instruments, from traditional devices for dissection and coagulation 2,3 to the most recent helium plasma (J-Plasma) device we implemented for the elevation of the free flap in microsurgery. 4 As with the Filis et al experience, 1 we have found advantages of this device over traditional devices, such as the possibility of performing dissection and hemostasis simultaneously, as well as the absence of muscle dissection and the absence of fat necrosis associated to nonformation of serum and/or burn tissues during dissection. Furthermore, we found a significant decreased risk of accidental tissue trauma.…”

Section: To the Editormentioning

confidence: 80%

“…As with the Filis et al experience, 1 we have found advantages of this device over traditional devices, such as the possibility of performing dissection and hemostasis simultaneously, as well as the absence of muscle dissection and the absence of fat necrosis associated to nonformation of serum and/or burn tissues during dissection. Furthermore, we found a significant decreased risk of accidental tissue trauma.…”

mentioning

confidence: 75%

“…We read with interest the article, "Use of low temperature helium plasma (J-Plasma) for dissection and hemostasis during carotid endarterectomy," 1 recently published in the Journal of Vascular Surgery Cases and Innovative Techniques. In our opinion, this article represents such an innovative surgical technique that deserves to be shared.…”

Section: To the Editormentioning

confidence: 99%

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Setting of helium plasma device (J-Plasma) in flap elevation

Starnoni

Pinelli

Santis

2020

Journal of Vascular Surgery Cases, Innovations and Techniques

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Section: To the Editormentioning

confidence: 80%

mentioning

confidence: 75%

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Setting of helium plasma device (J-Plasma) in flap elevation

Starnoni

Pinelli

Santis

2020

Journal of Vascular Surgery Cases, Innovations and Techniques

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“…However, the optimal settings to create full-thickness skin incisions have not previously been defined or reported. Other biomedical applications of cold plasma have been investigated, including infection control, chronic wound healing, coagulation, deep dissection in plastic and vascular surgery, and eradication of malignant disease [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Healing Potential of J-Plasma Scalpel-Created Surgical Incisions in Porcine and Rat Models

Elmore,

Minissale,

Israel

et al. 2024

Biomedicines

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Cold atmospheric plasma devices generate reactive oxygen and nitrogen species that can be anti-microbial but also promote cell migration, differentiation, and tissue wound healing. This report investigates the healing of surgical incisions created using cold plasma generated by the J-Plasma scalpel (Precise Open handpiece, Apyx Medical, Inc.) compared to a steel scalpel in in vivo porcine and rat models. The J-Plasma scalpel is currently FDA approved for the delivery of helium plasma to cut, coagulate, and ablate soft tissue during surgical procedures. To our knowledge, this device has not been studied in creating surgical incisions but only during deeper dissection and hemostasis. External macroscopic and histologic grading by blinded reviewers revealed no significant difference in wound healing appearance or physiology in incisions created using the plasma scalpel as compared with a steel blade scalpel. Incisions created with the plasma scalpel also had superior hemostasis and a reduction in tissue and blood carryover. Scanning electron microscopy (SEM) and histology showed collagen fibril fusion occurred as the plasma scalpel incised through the tissue, contributing to a sealing effect. In addition, when bacteria were injected into the dermis before incision, the plasma scalpel disrupted the bacterial membrane as visualized in SEM images. External macroscopic and histologic grading by blinded reviewers revealed no significant difference in wound healing appearance or physiology. Based on these results, we propose additional studies to clinically evaluate the use of cold plasma in applications requiring hemostasis or when an increased likelihood of subdermal pathogen leakage could cause surgical site infection (i.e., sites with increased hair follicles).

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“…CAP operates at body temperature, making it feasible for a variety of medical applications, such as chronic wound treatment; skin disinfection [16][17][18]; tissue regeneration in chronic leg ulcers [19]; dentistry [20]; in dermatology for the treatment of tumours, actinic keratosis, scars, ichthyosis, psoriasis, atopic eczema, as well as for alleviation of pain and itch [21][22][23]; and in haematology for blood coagulation [24,25]; in ophthalmology (human corneas) [26]. Recently there has been increased interest in clinical applications in anticancer therapy as a novel promising treatment [27], leading to a new field of medicine called "plasma oncology or plasma medicine" [8,28,29].…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

Žúbor

Wang

Líšková

et al. 2020

IJMS

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Vulvar cancer (VC) is a specific form of malignancy accounting for 5–6% of all gynaecologic malignancies. Although VC occurs most commonly in women after 60 years of age, disease incidence has risen progressively in premenopausal women in recent decades. VC demonstrates particular features requiring well-adapted therapeutic approaches to avoid potential treatment-related complications. Significant improvements in disease-free survival and overall survival rates for patients diagnosed with post-stage I disease have been achieved by implementing a combination therapy consisting of radical surgical resection, systemic chemotherapy and/or radiotherapy. Achieving local control remains challenging. However, mostly due to specific anatomical conditions, the need for comprehensive surgical reconstruction and frequent post-operative healing complications. Novel therapeutic tools better adapted to VC particularities are essential for improving individual outcomes. To this end, cold atmospheric plasma (CAP) treatment is a promising option for VC, and is particularly appropriate for the local treatment of dysplastic lesions, early intraepithelial cancer, and invasive tumours. In addition, CAP also helps reduce inflammatory complications and improve wound healing. The application of CAP may realise either directly or indirectly utilising nanoparticle technologies. CAP has demonstrated remarkable treatment benefits for several malignant conditions, and has created new medical fields, such as “plasma medicine” and “plasma oncology”. This article highlights the benefits of CAP for the treatment of VC, VC pre-stages, and postsurgical wound complications. There has not yet been a published report of CAP on vulvar cancer cells, and so this review summarises the progress made in gynaecological oncology and in other cancers, and promotes an important, understudied area for future research. The paradigm shift from reactive to predictive, preventive and personalised medical approaches in overall VC management is also considered.

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Utilization of low-temperature helium plasma (J-Plasma) for dissection and hemostasis during carotid endarterectomy

Cited by 3 publications

References 21 publications

Setting of helium plasma device (J-Plasma) in flap elevation

Setting of helium plasma device (J-Plasma) in flap elevation

Evaluating the Healing Potential of J-Plasma Scalpel-Created Surgical Incisions in Porcine and Rat Models

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

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