Utilization of raw and gelatinized starch by blunt snout bream Megalobrama amblycephala as evidenced by the glycolipid metabolism, glucose tolerance and mitochondrial function

Zhang, Li; Liu, Wenbin; Brown, Paul B.; Xu, Chao; Shi, Haojie; Zheng, Xiaochuan; Huang, Yeen; Li, Xiangfei

doi:10.1016/j.aquaculture.2020.735603

Cited by 16 publications

(10 citation statements)

References 56 publications

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“…A previous study in this species (16.2 g) fed with a commercial diet (>30% NFE) indicated 2 mmol/L blood glucose after 2 weeks of starvation (Eslamloo et al, 2017) might be due to difference in body size and long feed deprivation. Similar to the present finding, invariable glucose levels have been reported in S. latus (Wu et al, 2007), M. amblycephala (Zhang, Liu, et al, 2020) and S. fontinalis (Xu et al, 2020) fed different native and pregelatinized starches. On the other hand, O. mykiss (Felip et al, 2012) and P. hypophthalmus (Asemani et al, 2019) show elevated blood glucose for pregelatinized starch.…”

Section: Discussionsupporting

confidence: 91%

“…The results supported reduced (−5.9%) and slightly modified (0.8%) carbohydrate digestibility in pregelatinized sago and corn starches groups, respectively. Generally, dietary pregelatinized starch promotes lipid accumulation in the liver cells and the excess amount causes polarization of hepatocyte nucleus (Zhang, Liu, et al, 2020). Meanwhile, unchanged cell size in pregelatinized tapioca group further validated the maximum capacity of starch utilization with moderately improved (5%) carbohydrate digestibility.…”

Section: Discussionmentioning

confidence: 99%

“…However, protein digestibility is independent of dietary native or pregelatinized starch in blackspot seabream Pagellus bogaraveo (Figueiredo‐Silva et al, 2009) and D. labrax (Peres & Oliva‐Teles, 2002). Likewise, partial or complete replacement of native starch with pregelatinized form in the diet favourably influences intermediate metabolism, glucose tolerance and body growth in L. rohita (Kumar et al, 2008), brook trout Salvelinus fontinalis (Xu et al, 2020) and blunt snout bream Megalobrama amblycephala (Zhang, Li, et al, 2020; Zhang, Liu, et al, 2020). On the other hand, striped catfish Pangasianodon hypophthalmus (Asemani et al, 2019) and yellowfin seabream Sparus latus (Wu et al, 2007) effectively utilize native starches than their pregelatinized forms.…”

Section: Introductionmentioning

confidence: 99%

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Effects of native and pregelatinized starches on feed physical properties, digestibility, growth, nutrient utilization and histology of liver and intestine of juvenile tinfoil barb ( Barbonymus schwanenfeldii , Bleeker 1853)

Nafees

Kamarudin

Karim

et al. 2022

Aquaculture Research

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A 56‐day feeding trial was conducted to evaluate the effects of native and pregelatinized starches on feed quality, digestibility, growth, nutrient utilization, intestinal α‐amylase activity, plasma biochemical parameters and liver and intestine histology of Barbonymus schwanenfeldii juveniles. Six isonitrogenous and isocaloric diets were prepared using native and pregelatinized corn, sago and tapioca starches. Each diet was randomly assigned to triplicate groups of 20 fish (3.32 ± 0.02 g). Results revealed an interactive influence of starch source and pregelatinization (p < 0.05) on pellet expansion, sinking velocity, durability, water absorption index and water stability. However, the diets did not affect feed intake, growth and feed efficiency of fish. Accordingly, whole‐body composition, nutrient retention and body indices were also insignificant. Digestibility of dry matter, protein and carbohydrate depended on both starch sources and forms (p < 0.05) while α‐amylase activity varied with starch sources and gut regions (p < 0.05). Intestinal villus height of fish varied (p < 0.05) with starch sources and forms, whereas villus width and area differed among combinations of starch sources and forms (p < 0.05). Likewise, hepatocyte size of fish was different among dietary starch source and form combinations. However, the diets did not alter the plasma biochemical composition of fish. Overall, it was concluded that though pregelatinized starch improved pellet quality and nutrient digestibility, tinfoil barb juveniles could equally utilize 19.25% native and pregelatinized corn, tapioca and sago starches.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of native and pregelatinized starches on feed physical properties, digestibility, growth, nutrient utilization and histology of liver and intestine of juvenile tinfoil barb ( Barbonymus schwanenfeldii , Bleeker 1853)

Nafees

Kamarudin

Karim

et al. 2022

Aquaculture Research

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“…Compared to mammals, however, fish are limited in their ability to use carbohydrates, and they are prone to persistent hyperglycemia after carbohydrate intake [2]. Furthermore, high level of dietary carbohydrates leads to hepatic accumulation of glycogen and lipid, and metabolic disorders and decreases antioxidant capacity and immunity [3,4]. The utilization of carbohydrates and glucose metabolism regulation in fish have become one of the hot topics in the fish nutrition research in the past years.…”

Section: Introductionmentioning

confidence: 99%

Effects of Adiponectin on Glucose Metabolism in the Hepatopancreas of Grass Carp (Ctenopharyngodon idella)

Qin

Zhao

Yan

et al. 2022

Aquaculture Nutrition

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Adiponectin plays critical roles in the regulation of energy metabolism in mammals. However, its roles in fish remain to be evaluated. In this study, we examined the tissue distribution characteristics of two adiponectin genes, namely, adipoqa and adipoqb, at transcriptional level, and detected the changes of their mRNA expressions during oral glucose tolerance test (OGTT). Furthermore, we prepared recombinant proteins of grass carp adiponectin A and adiponectin B and studied their roles in the regulation of glucose metabolism in the hepatopancreas of grass carp in vivo. The results showed that adipoqa mRNA was mainly expressed in the heart of grass carp, followed by red muscle, white muscle, and adipose tissue, while adipoqb mRNA was highly expressed in adipose tissue, red muscle, and white muscle. The mRNA levels of adipoqa and adipoqb in the white muscle and heart were significantly decreased at 1 h post OGTT, and their expressions in the heart were also suppressed at 3 h, whereas the transcriptional levels of adipoqa and adipoqb in the red muscle were elevated significantly at 12 h after glucose load. Intraperitoneal injection of adiponectin A or adiponectin B reduced basal serum glucose levels of grass carp and caused an increase of glycogen content in the hepatopancreas. Adiponectin A upregulated the expression of enzyme genes related to glycolysis (gk and pk) and glycogen synthesis (gys) in the hepatopancreas, and adiponectin B promoted the expression of pk and gys, as well as g6pase in the glycogenetic pathway. Besides, adiponectin A and adiponectin B have opposite regulatory effects on glut2 mRNA expression. These results suggested that adiponectin A and adiponectin B promoted glycolysis, gluconeogenesis, and glycogen synthesis, increased glycogen content of hepatopancreas, and reduced basal blood glucose level, and they may have an antagonistic regulatory mechanism in regulating glucose uptake.

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“…The previous findings also demonstrated that changes in mitochondrial respiratory chain complex activity can lead to changes in tissue aerobic capacity, thereby affecting aerobic metabolism and ATP production [54]. Previous studies have reported that the expression levels of ATPase (atpase), NADH dehydrogenase (nd), succinate dehydrogenase complex subunit C (sdhc), cytochrome b (cytb), cytochrome c oxidase (cox), and silencing information regulator (sirt) were closely related to the synthesis of mitochondrial complexes [19,55,56], and in this study, genes related to energy metabolism all showed a trend of increasing first and then decreasing.…”

Section: H 1 H 2 H 3 H 6 H 12 Hmentioning

confidence: 96%

Dietary Corn Starch Levels Regulated Insulin-Mediated Glycemic Responses and Glucose Homeostasis in Swimming Crab (Portunus trituberculatus)

Zhang

Huang

Yang

et al. 2022

Aquaculture Nutrition

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Carbohydrate is the cheapest source of energy among the three major nutrient groups, an appropriate amount of carbohydrates can reduce feed cost and improve growth performance, but carnivorous aquatic animals cannot effectively utilize carbohydrates. The objectives of the present study are aimed at exploring the effects of dietary corn starch levels on glucose loading capacity, insulin-mediated glycemic responses, and glucose homeostasis for Portunus trituberculatus. After two weeks of feeding trial, swimming crabs were starved and sampled at 0, 1, 2, 3, 4, 5, 6, 12, and 24 hours, respectively. The results indicated that crabs fed diet with 0% corn starch exhibited lower glucose concentration in hemolymph than those fed with the other diets, and glucose concentration in hemolymph remained low with the extension of sampling time. The glucose concentration in hemolymph of crabs fed with 6% and 12% corn starch diets reached the peak after 2 hours of feeding; however, the glucose concentration in hemolymph of crabs fed with 24% corn starch attained the highest value after 3 hours of feeding, and the hyperglycemia lasted for 3 hours and decreased rapidly after 6 hours of feeding. Enzyme activities in hemolymph related to glucose metabolism such as pyruvate kinase (PK), glucokinase (GK), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly influenced by dietary corn starch levels and sampling time. Glycogen content in hepatopancreas of crabs fed with 6% and 12% corn starch first increased and then decreased; however, the glycogen content in hepatopancreas of crabs fed with 24% corn starch significantly increased with the prolongation of feeding time. In the 24% corn starch diet, insulin-like peptide (ILP) in hemolymph reached a peak after 1 hour of feeding and then significantly decreased, whereas crustacean hyperglycemia hormone (CHH) was not significantly influenced by dietary corn starch levels and sampling time. ATP content in hepatopancreas peaked at 1 h after feeding and then decreased significantly in different corn starch feeding groups, while the opposite trend was observed in NADH. The activities of mitochondrial respiratory chain complexes I, II, III, and V of crabs fed with different corn starch diets significantly increased first and then decreased. In addition, relative expressions of genes related to glycolysis, gluconeogenesis, glucose transport, glycogen synthesis, insulin signaling pathway, and energy metabolism were significantly affected by dietary corn starch levels and sampling time. In conclusion, the results of the present study reveal glucose metabolic responses were regulated by different corn starch levels at different time points and play an important role in clearing glucose through increased activity of insulin, glycolysis, and glycogenesis, along with gluconeogenesis suppression.

show abstract

Utilization of raw and gelatinized starch by blunt snout bream Megalobrama amblycephala as evidenced by the glycolipid metabolism, glucose tolerance and mitochondrial function

Cited by 16 publications

References 56 publications

Effects of native and pregelatinized starches on feed physical properties, digestibility, growth, nutrient utilization and histology of liver and intestine of juvenile tinfoil barb ( Barbonymus schwanenfeldii , Bleeker 1853)

Effects of native and pregelatinized starches on feed physical properties, digestibility, growth, nutrient utilization and histology of liver and intestine of juvenile tinfoil barb ( Barbonymus schwanenfeldii , Bleeker 1853)

Effects of Adiponectin on Glucose Metabolism in the Hepatopancreas of Grass Carp (Ctenopharyngodon idella)

Dietary Corn Starch Levels Regulated Insulin-Mediated Glycemic Responses and Glucose Homeostasis in Swimming Crab (Portunus trituberculatus)

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