Utilization of the microbiome in personalized medicine

Ratiner, Karina; Ciocan, Dragos; Abdeen, Suhaib K.; Elinav, Eran

doi:10.1038/s41579-023-00998-9

Cited by 32 publications

(6 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, the composition of the intestinal microbiome could be altered by vitD deficiency, and supplementation has been determined to improve gut microbiomes with a positive impact on their overall health and immune system function. Ultimately, fecal microbiota transplantation opens the possibility of manipulating the gut microbiota with pre-, pro-, and post-biotics to rejuvenate the immune system and connected organs, prospecting the analysis of microbiome data for personalized patient care [ 49 ].…”

Section: The Hallmarks Of Agingmentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

View full text Add to dashboard Cite

Aging is the result of several complex and multifactorial processes, where several agents contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases. The hallmarks of aging are a set of biological mechanisms that are finely regulated and strictly interconnected, initiating or contributing to biological changes and anticipating several age-related diseases. The complex network of cellular and intercellular connections between the hallmarks might represent a possible target for the research of agents with pleiotropic effects. Vitamin D (VitD) is known to have a positive impact not only on muscle and bone health but also on several extra-skeletal districts, due to the widespread presence of Vitamin D Receptors (VDRs). VitD and VDR could be molecules potentially targeting the hallmarks of the aging network. To date, evidence about the potential effects of VitD on the hallmarks of aging is scarce in humans and mainly based on preclinical models. Although underpowered and heterogeneous, in-human studies seem to confirm the modulatory effect of VitD on some hallmarks of aging and diseases. However, more investigations are needed to clarify the pleiotropic effects of VitD and its impact on the hallmark of aging, hopefully highlighting the courses for translational applications and potential clinical conclusions.

show abstract

Section: The Hallmarks Of Agingmentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Moreover, the microbiome plays a critical role in modulating the immune system, which is essential for fighting off infections. By understanding an individual's microbiome profile, healthcare professionals can gain insights into the functioning of the immune system and its dysregulation in infectious diseases [323][324][325]. This knowledge can guide the development of immunomodulatory therapies that target specific pathways or immune cell populations, ultimately enhancing the body's ability to combat infections.…”

Section: Personalized Medicine Approachesmentioning

confidence: 99%

“…Personalized medicine based on an individual's microbiome profile also offers the opportunity to uncover new therapeutic targets for infectious diseases. The microbiome is a rich source of bioactive molecules and metabolites that can have diverse effects on human health and disease [323,324,340]. By studying the microbial communities within the microbiome, researchers can identify specific molecules or pathways that contribute to disease progression or protection against infections.…”

Section: Personalized Medicine Approachesmentioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

View full text Add to dashboard Cite

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

show abstract

“…To date, the tumour microbiome has been implicated in modulating anti-tumoural immune responses, chemotherapy efficacy, and tumour progression (Helmink et al 2019 ; Cullin et al 2021 ; Sepich-Poore et al 2021 ). Apart from tissues, microbial signatures from other collection sites such as stool and saliva may have diagnostic or prognostic roles in various cancers (Thomas et al 2019 ; Ratiner et al 2023 ; Yang et al 2023a ). Together these studies demonstrate the potential impact of understanding the tumour microbiome in cancers.…”

Section: Introductionmentioning

confidence: 99%

A comparison between full-length 16S rRNA Oxford nanopore sequencing and Illumina V3-V4 16S rRNA sequencing in head and neck cancer tissues

Yeo,

Connell,

Bouras

et al. 2024

Arch Microbiol

View full text Add to dashboard Cite

Describing the microbial community within the tumour has been a key aspect in understanding the pathophysiology of the tumour microenvironment. In head and neck cancer (HNC), most studies on tissue samples have only performed 16S rRNA short-read sequencing (SRS) on V3-V5 region. SRS is mostly limited to genus level identification. In this study, we compared full-length 16S rRNA long-read sequencing (FL-ONT) from Oxford Nanopore Technology (ONT) to V3-V4 Illumina SRS (V3V4-Illumina) in 26 HNC tumour tissues. Further validation was also performed using culture-based methods in 16 bacterial isolates obtained from 4 patients using MALDI-TOF MS. We observed similar alpha diversity indexes between FL-ONT and V3V4-Illumina. However, beta-diversity was significantly different between techniques (PERMANOVA - R2 = 0.131, p < 0.0001). At higher taxonomic levels (Phylum to Family), all metrics were more similar among sequencing techniques, while lower taxonomy displayed more discrepancies. At higher taxonomic levels, correlation in relative abundance from FL-ONT and V3V4-Illumina were higher, while this correlation decreased at lower levels. Finally, FL-ONT was able to identify more isolates at the species level that were identified using MALDI-TOF MS (75% vs. 18.8%). FL-ONT was able to identify lower taxonomic levels at a better resolution as compared to V3V4-Illumina 16S rRNA sequencing.

show abstract

Utilization of the microbiome in personalized medicine

Cited by 32 publications

References 217 publications

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

A comparison between full-length 16S rRNA Oxford nanopore sequencing and Illumina V3-V4 16S rRNA sequencing in head and neck cancer tissues

Contact Info

Product

Resources

About