Utilization of the ‘QUAD SHOT’ for Palliating Malignancies of the Head and Neck

Lorenz, J; Fain, Robert; Robbins, Jared R.

doi:10.1016/j.ijrobp.2018.07.1289

Cited by 2 publications

(2 citation statements)

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“…Quad shots 10 and resimulations (eg, adaptive planning) composed 137 of the total 511 cases. With the omission of these cases, the percentage of cases that required no changes decreased from 58.3% to 47.9%.…”

Section: Resultsmentioning

confidence: 99%

Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology

Hesse¹,

Chen²,

Yu³

et al. 2022

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Resultsmentioning

confidence: 99%

Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology

Hesse¹,

Chen²,

Yu³

et al. 2022

Advances in Radiation Oncology

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“…A recent NCDB analysis reported that 7% of patients with HNC treated with palliative RT receive QS [ 36 ]. Pre-clinical studies and early clinical studies suggest that a combination of immunotherapy with QS radiation may be more effective than either treatment alone in treating locally advanced HNC [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Palliative Quad Shot Radiation Therapy with or without Concurrent Immune Checkpoint Inhibition for Head and Neck Cancer

Upadhyay,

Gogineni,

Tocaj

et al. 2024

Cancers

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Objectives: Patients with recurrent and metastatic head and neck cancer (HNC) have limited treatment options. ‘QuadShot’ (QS), a hypofractionated palliative radiotherapy regimen, can provide symptomatic relief and local control and may potentiate the effects of immune checkpoint inhibitors (ICIs). We compared outcomes of QS ± concurrent ICIs in the palliative treatment of HNC. Materials and Methods: We identified patients who received ≥three cycles of QS from 2017 to 2022 and excluded patients without post-treatment clinical evaluation or imaging. Outcomes for patients who received QS alone were compared to those treated with ICI concurrent with QS, defined as receipt of ICI within 4 weeks of QS. Results: Seventy patients were included, of whom 57% received concurrent ICI. Median age was 65.5 years (interquartile range [IQR]: 57.9–77.8), and 50% patients had received prior radiation to a median dose of 66 Gy (IQR: 60–70). Median follow-up was 8.8 months. Local control was significantly higher with concurrent ICIs (12-month: 85% vs. 63%, p = 0.038). Distant control (12-month: 56% vs. 63%, p = 0.629) and median overall survival (9.0 vs. 10.0 months, p = 0.850) were similar between the two groups. On multivariable analysis, concurrent ICI was a significant predictor of local control (HR for local failure: 0.238; 95% CI: 0.073–0.778; p = 0.018). Overall, 23% patients experienced grade 3 toxicities, which was similar between the two groups. Conclusions: The combination of QS with concurrent ICIs was well tolerated and significantly improved local control compared to QS alone. The median OS of 9.4 months compares favorably to historical controls for patients with HNC treated with QS. This approach represents a promising treatment option for patients with HNC unsuited for curative-intent treatment and warrants prospective evaluation.

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Utilization of the ‘QUAD SHOT’ for Palliating Malignancies of the Head and Neck

Cited by 2 publications

References 0 publications

Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology

Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology

Palliative Quad Shot Radiation Therapy with or without Concurrent Immune Checkpoint Inhibition for Head and Neck Cancer

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