Utilization of the Quantitative Assay of Lipoprotein X in the Differential Diagnosis of Extrahepatic Obstructive Jaundice and Intrahepatic Diseases

Magnani, H.N.; Alaupovic, Petar

doi:10.1016/s0016-5085(76)80103-5

Cited by 23 publications

(2 citation statements)

References 19 publications

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“…There was no peak in the position of LP-X with agarose column chromatography, and no particles like LP-X were seen on electron microscopy. Many other patients with 'cholestasis' have been reported to have had no detectable LP-X in the plasma (Magnani & Alaupovic, 1976;Vergani, Pietrogrande & Grondona, 1973;Ross, Murphy, Wilkinson, Mills & Sherlock, 1970;Ritland, Blomhoff, Elgjo & Gjone, 1973;Mordasini, Berthold, Schlumpf, Keller & Riva, 1975). Seidel (1976) has also claimed that the con centration of LP-X in plasma does not correlate with LCAT activity.…”

Section: Discussionmentioning

confidence: 99%

Lecithin—Cholesterol Acyltransferase and the Lipoprotein Abnormalities of Obstructive Jaundice

et al. 1978

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1. We have studied the plasma lipoprotein abnormalities in obstructive jaundice to test the hypothesis that the abnormalities would correlate with plasma lecithin--cholesterol acyltransferase activity. 2. Very-low-density lipoproteins (VLDL) were normal in composition and had a normal pre-beta electrophoretic mobility when lecithin--cholesterol acyltransferase activity was high. When it was low VLDL had abnormal composition and ran in the beta position. 3. With high lecithin--cholesterol acyltransferase activity, low-density lipoprotein (LDL) was normal and cholestatic LDL (LP-X) was not found. With low lecithin--cholesterol acyltransferase activity up to three LDL fractions were found: (i) large triglyceride-rich particles, (ii) LP-X and (iii) a triglyceride-rich cholesteryl ester-poor particle of normal dimensions. 4. High-density lipoprotein (HDL) concentrations correlated with lecithin--cholesterol acyltransferase activity and HDL were normal in composition and electron-microscopic appearance when the activity was high. When lecithin--cholesterol acyltransferase activity was low HDL was abnormal in composition and 'stacked discs' were seen on electron microscopy as well as normal spherical particles. 5. These results suggest that low lecithin-cholesterol acyltransferase activity may cause at least some of the lipoprotein changes of obstructive jaundice.

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Section: Discussionmentioning

confidence: 99%

Lecithin—Cholesterol Acyltransferase and the Lipoprotein Abnormalities of Obstructive Jaundice

et al. 1978

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“…1976). Οι Magnani καί Alaupovic (1976) καί ό Ritland (1975) έμέτρησαν τό ποσόν τής LP-X είς τό πλάσμα καί ύπεστήριξαν οτι αύτη βοηθά εις τήν διαφορικήν διαγνωστικήν τής χολοστάσεως. Κατά τήν έπανεκτίμησιν όμως τών δεδομένων αυτών, διεπιστώθη οτι δέν δύναται νά γίνει σαφής διαφορική διάγνωσις μεταξύ έξωηπατικής καί ενδοηπατικής χολοστάσεως βάσει τών επιπέδων τής LP-X του πλάσματος.…”

Section: λιποπρωτεΐνη χ (Lp-x)unclassified

Διαταραχαι Των Λιποπρωτεινων Ως Εκδηλωσις Ηπατοκυτταρικης Βλαβης Επι Πειραματικης Ηπατιτιδος Δια Τετραχλωρανθαρακος Και Αλκοολης

Δημοπουλοσ¹

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Την άσκησιν προς άπόκτησιν της ειδικότητος της Παθολογίας άρχισα καί ολοκλήρωσα εις την Δ' Παθολογικήν Κλινικήν του Θεραπευτηρίου «Ο ΕΥΑΓΓΕΛΙΣΜΟΣ» από 7.12.71 μέχρι 6.8.74. 'Από 7.9.74 μέχρι 6.9.75 ήργάσθην είς την ανωτέρω κλινική ώς εσωτε ρικός ιατρός. 'Από του Νοεμβρίου 1975 μέχρι του Σεπτεμβρίου 1977 ήργάσθην είς τήν Μονάδα Τεχνικού Νεφρού «Σ. ΚΑΜΙΝΗΣ» εις τήν Κλινική «ΠΑΓΩΝΗ». 'Από του 'Οκτωβρίου 1977 μέχρι του Δεκεμβρίου 1980 ήργάσθην ώς εσωτερικός Βοηθός εις τό Γαστρεντερολογικόν Έργαστήριον τοϋ Θερα πευτηρίου «Ο ΕΥΑΓΓΕΛΙΣΜΟΣ» όπου καί έξεπλήρωσα τόν χρόνον ειδικό τητος τής Γαστρεντερολογίας. Ή παρούσα διατριβή έγένετο ύπό τήν έποπτείαν τοϋ Καθηγητού τής Β' Προπαιδευτικής Παθολογικής Κλινικής τοΰ Πανεπιστημίου 'Αθηνών κ. Κ. Γαρδίκα.

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The Liver and Biliary System

Hyams¹

1983

Geriatrics 2

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Utilization of the Quantitative Assay of Lipoprotein X in the Differential Diagnosis of Extrahepatic Obstructive Jaundice and Intrahepatic Diseases

Cited by 23 publications

References 19 publications

Lecithin—Cholesterol Acyltransferase and the Lipoprotein Abnormalities of Obstructive Jaundice

Lecithin—Cholesterol Acyltransferase and the Lipoprotein Abnormalities of Obstructive Jaundice

Διαταραχαι Των Λιποπρωτεινων Ως Εκδηλωσις Ηπατοκυτταρικης Βλαβης Επι Πειραματικης Ηπατιτιδος Δια Τετραχλωρανθαρακος Και Αλκοολης

The Liver and Biliary System

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