Utilization of the Viscum Species for Diet and Medicinal Purposes in Ruminants: A Review

Hawu, Onke; Ravhuhali, Khuliso Emmanuel; Musekwa, Mutshidzi Given; Sipango, Nkosomzi; Mudau, Humbelani Silas; Mokoboki, Kwena Hilda; Moyo, Bethwell

doi:10.3390/ani12192569

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…Furthermore, veterinary medicine and/or homeopathy are the most promising fields for future applications [ 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 ], not excluding the antiviral properties, which ask for further continuous attention [ 262 ]. Therefore, the knowledge about European mistletoe properties is in continuous evolution and requires a continuous revision of its use in evidence-based complementary and alternative medicine [ 263 , 264 , 265 , 266 ].…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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The therapeutic story of European mistletoe (Viscum album L.) presents a seesawing profile. In ancient times, this hemiparasitic plant was considered a panacea and even to be endowed with exceptional beneficial properties. In more recent times, despite its multiple uses in traditional medicines, some parts of the plant, in particular the berries, were considered poisonous and dangerous, including concerns of cytotoxicity, which spread serious suspicion on its medicinal utility. However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. In Central Europe, the hydro-alcoholic extracts of European mistletoe register a relevant and continuous utilization in anthroposophic medicine, which is a holistic system that includes the utilization of phytomedicinal substances. In Switzerland and Germany, most physicians and patients use these products as complementary therapy in oncological treatments. However, despite its increasing use in this field, the results of mistletoe’s use are not always convincing, and other aspects have appeared. Nowadays, products that contain mistletoe are utilized in several fields, including diet, phytotherapy, veterinary medicine and homeopathy, but in particular in cancer therapies as coadjuvant factors, in consideration of several positive effects including effects in the improvement of quality-of-life conditions and reinforcement of the immune system. In this review, based on the understanding of the association between cancer and inflammation, we propose a relationship between these recent uses of mistletoe, based on its antioxidant properties, which are supported by phytochemical and pharmacological data. The unicity of mistletoe metabolism, which is a direct consequence of its hemiparasitism, is utilized as a key interpretation element to explain its biological properties and steer its consequent therapeutic uses.

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Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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“…In other mistletoe genus ( Viscum spp. ), flavonoids, alkaloids and saponins were identified ( Hawu et al, 2022 ). Compounds belonging to hydroxycinnamic acid derivatives like coumaric acid, ferulic acid, caffeic acid and chlorogenic acid are phytochemicals present in the fruits and aerial pars of several plants, which are known to exert beneficial effects linked to their antioxidant and anthelmintic activity ( Mancilla-Montelongo et al, 2019 ; Ondua et al, 2021 ; Orzuna-Orzuna et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Bioactive compounds from the parasitic plant Arceuthobium vaginatum inhibit Haemonchus contortus egg hatching

Becerril-Gil,

Estrada-Flores,

González-Cortazar

et al. 2024

Rev. Bras. Parasitol. Vet.

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The aim of this study was to assess the in vitro ovicidal activity of an ethyl acetate extract from Arceuthobium vaginatum (EtOAc-E) and their subfractions (AvR5-AvR14) against Haemonchus contortus using the egg hatching inhibition (EHI) test. The EtOAc-E and subfractions were tested at 0.12-2.00 and at 0.015-2.0 mg/mL, respectively. Distilled water and methanol (2%) were used as negative controls and Thiabendazole (0.10 mg/mL) as a positive control. Treatments with a dependent effect on concentration were subjected to regression analysis to determine the effective concentrations (EC50 and EC90). The major secondary compounds present in the extract and subfractions were identified by high performance liquid chromatography (HPLC). The EtOAc-E and AvR9 exhibited the best ovicidal effect recording 97.5 and 100% of EHI at 0.25 mg/mL, respectively. The EtOAc-E and AvR9 displayed an EC50= 0.12 and 0.08 mg/mL, respectively. The HPLC analysis in the EtOAc-E and bioactive fractions indicated the presence of a polyphenol, glycosylated flavanones, quercetin glucoside, cinnamates, coumarin, cinnamic acid derivative, ferulic acid, coumarate, naringenin, protocatechuic acid and naringin. Results demonstrated that A. vaginatum extract and fraction is able to inhibit the egg hatch process of H. contortus and could be a viable option for the control of small ruminant haemonchosis.

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“…The phenolic compound content of yellow mistletoe was lower than those reported by Hernández-Luna et al (2017), and higher than that reported for mistletoe. Viscum rotundifolium with 7.3 g/kg DM of total tannins (Hawu et al, 2022). In traditional Mexican medicine of black mistletoe, as it is a medicinal plant used for the treatment of several ailments like an anti-inflammatory and nervous system relaxant (Biblioteca Digital de la Medicina Tradicional Mexicana, 2022), and has also been shown to have antimicrobial activity against Clavibacter michiganenses (García-García et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

NUTRITIONAL COMPOSITION OF Arceuthobium vaginatum subsp. vaginatum AND A. globosum subsp. grandicaule AND THEIR EFFECT ON IN VITRO RUMINAL FERMENTATION KINETICS

Becerril-Gil,

Olmedo-Juárez,

Endara-Agramont

et al. 2023

Trop Subtrop Agroecosyst

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Background: Arceuthobium vaginatum subsp. vaginatum (BM; black mistletoe) and Arceuthobium globosum subsp. grandicaule (YM; yellow mistletoe), are two parasitic plant species abundant in the forests of northern and central Mexico and Central America, affect 43% of the P. hartwegii tree population in the Nevado de Toluca Flora and Fauna Protection Area (NTFFPA), including mistletoe as a complementary feed in sheep can reduce the environmental impact generated by these pests to the forest and also reduce the purchase of feed for livestock. Objective: To evaluate the chemical composition, phenolic content and in vitro fermentation kinetics of two mistletoe species (M) Arceuthobium vaginatum subsp. vaginatum (BM; black mistletoe) and A. globosum subsp. grandicaule (YM; yellow mistletoe), in four age categories (AC) of Pinus hartwegii (AC: small sapling, large sapling, juvenile and adult) collected in the Nevado de Toluca Flora and Fauna Protection Area (NTFFPA). Methodology: The chemical composition (dry matter DM; neutral detergent fiber NDF; acid detergent fiber ADF and crude protein CP), phenolic content (total phenols TP; total tannins TT and condensed tannins, CT), in vitro fermentation kinetics parameters and in vitro digestibility were analysed. The experimental design used was completely randomized design with 2x4 factorial arrangement. Results: DM content was different between M (P< 0.05), the highest was found in BM. The NDF and ADF content was different between M, ranging from 364.45-467.43 g/kg DM. No differences (P>0.05) were observed in CP which averaged 62.08 g/kg DM. The TP, TT and CT content was different between M (P<0.05), the highest content was in YM with no effect observed in AC. B-gas production (mL of gas) presented differences between M and AC sampled (P<0.05). The gas production rate c on average was 0.042. Lag time was different between M (P<0.05). The in vitro digestibility of dry matter and organic matter were different between M (P<0.05). Implications: The results reported here serve as a tool for decision making on its possible inclusion as a forage addition to a diet in sheep feeding. Conclusions: The chemical composition and in vitro digestibility was different between M and the AC, contain secondary metabolites such as total phenols and condensed tannins and have an impact on in vitro fermentation.

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Utilization of the Viscum Species for Diet and Medicinal Purposes in Ruminants: A Review

Cited by 5 publications

References 62 publications

The Anti-Inflammatory Activity of Viscum album

The Anti-Inflammatory Activity of Viscum album

Bioactive compounds from the parasitic plant Arceuthobium vaginatum inhibit Haemonchus contortus egg hatching

NUTRITIONAL COMPOSITION OF Arceuthobium vaginatum subsp. vaginatum AND A. globosum subsp. grandicaule AND THEIR EFFECT ON IN VITRO RUMINAL FERMENTATION KINETICS

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