Utilization of Tin(IV) Complex of N‐Confused Porphyrin for Antiproliferative Activity and Antimicrobial Photodynamic Chemotherapy

Abstract

Sn(IV) complex of N‐Confused Porphyrin (Sn(IV)‐NCP) has been prepared and characterized by several spectroscopic techniques to verify its structure and purity. Sn(IV)‐NCP shows a red shift in both the Soret and Q bands compared to the free base NCTPP. The last Q band appears in the NIR region. Based on these characteristics, we investigated the antiproliferative properties and antimicrobial photodynamic therapy (a‐PDT) efficiency of Sn(IV)‐NCP against the bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Further, we investigated the photodynamic activity of Sn (IV)‐NCP against Michigan cancer foundation‐7 (MCF‐7) cancer cells, to assess its potential as an effective therapeutic agent. Treated MCF‐7 cells with the compound show cytotoxic effects as compared to the untreated ones. At a higher concentration (128 µg/ml), Sn(IV)‐NCP exhibited 90% inhibition, while at a lower concentration (32 µg/ml), it showed 70% inhibition in MCF‐7 cells. The IC50 value for this compound against MCF‐7 cells was found 16.67 µg/ml. At 32 µg/ml, Sn(IV)‐NCP showed only around 4% cell inhibition, indicating minimal cytotoxic effects on human embryonic kidney cells (HEK293).