Utilization Pattern of Non-steroidal Anti-inflammatory Drugs at a Primary Health Care in Malaysia

Khairudin, Khairani Azian; Jatau, Abubakar Ibrahim; Manan, Mohamed Mansor; Tiong, Chua Say; Chitneni, Mallikarjun; Abdullah, Abdul Manaf; Mahalingam, Sundara Rajan; Arshad, Kamaruddin

doi:10.5530/ijper.51.1.21

Cited by 4 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The private healthcare settings in Malaysia can essentially be divided into three: (a) general practitioner clinics, (b) community pharmacies, and (c) private hospitals. The private sector provides a healthcare service for a non-subsidised fee-for-service through a large network of private general practitioner clinics, community pharmacies and hospitals financed through out-of-pocket payments, private insurance or third-party payments [ 1 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

et al. 2020

Self Cite

View full text Add to dashboard Cite

Introduction: Drug utilization of analgesics in a private healthcare setting is useful to examine their prescribing patterns, especially the newer injectable cyclooxygenase (COX)-2 inhibitors (coxibs). Objectives: To evaluate the utilization of coxibs and traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) indicated for postoperative orthopaedic pain control using defined daily dose (DDD) and ratio of use density to use rate (UD/UR). Method: A retrospective drug utilization review (DUR) of nonsteroidal anti-inflammatory drugs (NSAIDs) at an inpatient department of a private teaching hospital in Seremban, Malaysia was conducted. Patients’ demographic characteristics, medications prescribed, clinical lab results, visual analogue scale (VAS) pain scores and length of hospital stay were documented. Orthopaedic surgeries, namely arthroscopy, reconstructive, and fracture fixation, were included. Stratified random sampling was used to select patients. Data were collected through patients’ medical records. The DDD per 100 admissions and the indicator UD/UR were calculated with the World Health Organization’s DDD as a benchmark. The inclusion criteria were patients undergoing orthopaedic surgery prescribed with coxibs (celecoxib capsules, etoricoxib tablets, parecoxib injections) and tNSAIDs (dexketoprofen injections, diclofenac sodium tablets). Data were analysed descriptively. This research was approved by the academic institution and the hospital research ethics committee. Result: A total of 195 records of patients who received NSAIDs were randomly selected among 1169 cases. In term of the types of orthopaedic surgery, the ratio of included records for arthroscopy:fracture fixation:reconstructive surgery was 55.4:35.9:8.7. Most of the inpatients had low rates of common comorbidities such as cardiovascular disease as supported by their baseline parameters. The majority were not prescribed with other concomitant prescriptions that could cause drug interaction (74.9%), or gastroprotective agents (77.4%). Overall, DDDs per 100 admissions for all NSAIDs were less than 100, except for parecoxib injections (389.23). The UD/UR for all NSAIDs were less than 100, except for etoricoxib tablets (105.75) and parecoxib injections (108.00). Discussion: As per guidelines, the majority (96.9%) received other analgesics to ensure a multimodal approach was carried out to control pain. From the UD/UR results, the arthroscopy surgery was probably the most appropriate in terms of NSAID utilization. Conclusion: The prescribing pattern of NSAIDs except parecoxib was appropriate based on adverse effect and concurrent medication profile. The findings of this DUR provide insight for a low-risk patient population at a private specialized teaching hospital on the recommended use of NSAIDs for postoperative orthopaedic pain control.

show abstract

Section: Introductionmentioning

confidence: 99%

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, the hydrogen bonding, π – π interaction and hydrophobic interaction that could be formed with NSAIDs would allow the modified nanocomposite to selectively entrap and bind the NSAIDs at the surface.The NSAIDs group namely INP, KTP, IBP and FNP as illustrated in Fig. 1 were selected as analytes because of their frequent consumption as drugs in Malaysia based on an Anatomical Therapeutic Chemical (ATC) report ( Khairudin et al, 2017 ). Hence, the occurrence probability of these NSAIDs in water samples is very high due to their high consumption among the Malaysian population ( Khairudin et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…1 were selected as analytes because of their frequent consumption as drugs in Malaysia based on an Anatomical Therapeutic Chemical (ATC) report ( Khairudin et al, 2017 ). Hence, the occurrence probability of these NSAIDs in water samples is very high due to their high consumption among the Malaysian population ( Khairudin et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of calixarene-grafted bio-polymeric magnetic composites for magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in water samples

Yaacob

Jamil

Kamboh

et al. 2018

PeerJ

View full text Add to dashboard Cite

Calixarene framework functionalized bio-polymeric magnetic composites (MSp-TDI-calix) were synthesized and utilized as magnetic solid-phase extraction (MSPE) sorbent for the extraction of non-steroidal anti-inflammatory drugs (NSAIDs), namely indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP) and fenoprofen (FNP), from environmental water samples. MSp-TDI-calix was characterized by FT-IR, XRD, FESEM, EDX, VSM and BET analysis, and the results were compared with Sp-TDI and Sp-TDI-calix. To maximize the extraction performance of MSp-TDI-calix decisive MSPE affective parameters such as sorbent amount, extraction time, sample volume, type of organic eluent, volume of organic eluent, desorption time and pH were comprehensively optimized prior to HPLC-DAD determination. The analytical validity of the proposed MSPE method was evaluated under optimized conditions and the following figures of merit were acquired: linearity with good determination coefficient (R2 ≥ 0.991) over the concentration range of 0.5–500 µg/L, limits of detection (LODs) ranged from 0.06–0.26 µg/L and limits of quantitation (LOQ) between 0.20–0.89 µg/L. Excellent reproducibility and repeatability under harsh environment with inter-day and intra-day relative standard deviations were obtained in the range of 2.5–3.2% and 2.4–3.9% respectively. The proposed method was successfully applied for analysis of NSAIDs in tap water, drinking water and river water with recovery efficiency ranging from 88.1–115.8% with %RSD of 1.6–4.6%.

show abstract

“…In addition, the hydrogen bonding, π-π interaction and hydrophobic interaction that could be formed with NSAIDs would allow the modified nanocomposite to selectively entrap and bind the NSAIDs at the surface.The NSAIDs group namely INP, KTP, IBP and FNP as illustrated in Fig. 1 were selected as analytes because of their frequent consumption as drugs in Malaysia based on Anatomical Therapeutic Chemical (ATC) report (Khairudin et al, 2017). Hence, the occurrence probability of these NSAIDs in water samples is very high due to its high consumption among the Malaysian population (Khairudin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…1 were selected as analytes because of their frequent consumption as drugs in Malaysia based on Anatomical Therapeutic Chemical (ATC) report (Khairudin et al, 2017). Hence, the occurrence probability of these NSAIDs in water samples is very high due to its high consumption among the Malaysian population (Khairudin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #2 of "Fabrication of calixarene-grafted bio-polymeric magnetic composites for magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in water samples (v0.1)"

2018

View full text Add to dashboard Cite

Calixarene framework functionalized bio-polymeric magnetic composites (MSp-TDI-calix) were synthesized and utilized as magnetic solid-phase extraction (MSPE) sorbent for the extraction of non-steroidal anti-inflammatory drugs (NSAIDs), namely indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP) and fenoprofen (FNP), from environmental water samples. MSp-TDI-calix was characterized by FT-IR, XRD, FESEM, EDX, VSM and BET analysis, and the results were compared with Sp-TDI and Sp-TDI-calix. To maximize the extraction performance of MSp-TDI-calix decisive MSPE affective parameters such as sorbent amount, extraction time, sample volume, type of organic eluent, volume of organic eluent, desorption time and pH were comprehensively optimized prior to HPLC-DAD determination. The analytical validity of the proposed MSPE method was evaluated under optimized conditions and the following figures of merit were acquired: linearity with good determination coefficient (R 2 ≥ 0.991) over the concentration range of 0.5-500 µg/L, limits of detection (LODs) ranged from 0.06-0.26 µg/L and limits of quantitation (LOQ) between 0.20-0.89 µg/L. Excellent reproducibility and repeatability under harsh environment with inter-day and intra-day relative standard deviations were obtained in the range of 2.5-3.2% and 2.4-3.9% respectively. The proposed method was successfully applied for analysis of NSAIDs in tap water, drinking water and river water with recovery efficiency ranging from 88.1-115.8% with %RSD of 1.6-4.6%.

show abstract

Utilization Pattern of Non-steroidal Anti-inflammatory Drugs at a Primary Health Care in Malaysia

Cited by 4 publications

References 10 publications

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

Fabrication of calixarene-grafted bio-polymeric magnetic composites for magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in water samples

Peer Review #2 of "Fabrication of calixarene-grafted bio-polymeric magnetic composites for magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in water samples (v0.1)"

Contact Info

Product

Resources

About