Utilization Pattern of Vancomycin in a University Teaching Hospital in Oman: Comparison with International Guidelines

Za’abi, Mohammed Al; Shafiq, Samreen; Riyami, Dawood Al; Ali, Badreldin H.

doi:10.4314/tjpr.v12i1.19

Cited by 6 publications

(12 citation statements)

References 16 publications

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“…[11] Many studies performed to evaluate vancomycin prescription according to the guidelines which listing appropriate and inappropriate situations for vancomycin use. [6121314151619]…”

Section: Discussionmentioning

confidence: 99%

“…However, reports of several performed studies in the past decade showed, up to 88% appropriate use of vancomycin based on CDC recommendation. [6141516]…”

Section: Discussionmentioning

confidence: 99%

“…[13141516] This controversy may be related to the different reasons' prevalence of vancomycin administrations.…”

Section: Discussionmentioning

confidence: 99%

“…This result is similar to the previous study which evaluated vancomycin prescription among 365 patients in a tertiary care hospital in 2013. [14] Excessive use of vancomycin is really alarming because of increasing resistant organisms.…”

Section: Discussionmentioning

confidence: 99%

“…[15] Lack of confidence to the culture results and critical condition of patients could be considered as the frequent reasons to continue inappropriate use of vancomycin in our study which also have been observed in some other developing countries. [1426]…”

Section: Discussionmentioning

confidence: 99%

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A new approach to Vancomycin utilization evaluation: A cross-sectional study in intensive care unit

2016

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Objective:The risk of methicillin-resistant Staphylococcus aureus infections in Intensive Care Unit (ICU) is increasing in recent years with high rate of morbidity and mortality. Therefore, in this study, we aimed to evaluate the rationale use of vancomycin in ICU patients.Methods:A total of 200 patients who received at least 48 h intravenous vancomycin were randomly selected from ICU wards, during 9 months. Vancomycin administration and related clinical and laboratory data were gathered from patients' charts and health information system to evaluate the appropriateness of different aspects of vancomycin use during all days which vancomycin were ordered.Findings:During the study, 15,230 ± 1216 mg (mean ± standard error of the mean [SEM]) vancomycin was administered for 200 patients in the mean period of 9.79 ± 0.64 (SEM) days of ICU stay, for prophylaxis and empiric therapy. Results showed the appropriateness of vancomycin uses were 30.5%, 9%, and 5.5% in the first 24 h, after 72 h and during the whole time of treatment, respectively. In addition, infectious consultation was the only significantly different parameter between appropriate and inappropriate vancomycin administration groups (P < 0.001).Conclusion:Although vancomycin utilization evaluation were mentioned in previous studies, but data related to ICU patients and during all days of vancomycin therapy are limited. High prevalence of inappropriate use of vancomycin in ICU is alarming for health systems and necessitates implementation of antibiotic policies.

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“…[11] Many studies performed to evaluate vancomycin prescription according to the guidelines which listing appropriate and inappropriate situations for vancomycin use. [6121314151619]…”

Section: Discussionmentioning

confidence: 99%

“…However, reports of several performed studies in the past decade showed, up to 88% appropriate use of vancomycin based on CDC recommendation. [6141516]…”

Section: Discussionmentioning

confidence: 99%

“…[13141516] This controversy may be related to the different reasons' prevalence of vancomycin administrations.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A new approach to Vancomycin utilization evaluation: A cross-sectional study in intensive care unit

2016

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Vancomycin therapeutic drug monitoring service quality indices and clinical effectiveness outcomes: A retrospective cohort and clinical audit

Al-Sulaiti

Nader

Elmekaty

et al. 2020

J Am Coll Clin Pharm

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Introduction:Vancomycin is commonly used for the treatment of complicated infections caused by methicillin-resistant Staphylococcus aureus. The impact of vancomycin therapeutic drug monitoring (TDM) quality indices on clinical outcomes has not been previously explored.Objectives: This study aims to relate routine vancomycin TDM service quality indices to clinical effectiveness outcomes and to develop a pragmatic vancomycin-specific TDM quality assessment tool that can be used in quality audits.Methods: A retrospective chart review was conducted on adult non-dialysis vancomycin TDM records documented between January 2014 and October 2016 in three tertiary care hospitals under Hamad Medical Corporation (HMC) in Qatar. Evidencebased criteria and pilot-testing were applied to develop a quality assessment tool.The appropriateness of vancomycin TDM service and clinical outcomes were simultaneously evaluated.Results: A 13-criterion vancomycin TDM quality assessment tool was developed and used to evaluate 208 TDM records involving 99 patients. The indications for TDM requests were judged appropriate in 77.4% (n = 161) of the records. However, most of the blood samples were deemed to be incorrectly timed (70.7%, n = 147). Inappropriate vancomycin TDM practices compared with appropriate practices were associated with lower therapeutic cure (47.3% vs 75%, P-value = .009).Conclusions: Vancomycin TDM requests were justified at HMC. However, inappropriate practices were associated with suboptimal clinical outcomes, signifying the importance of routine quality audits using rigorous evaluation tools. The developed tool can be used to determine setting-specific deficiencies in routine vancomycin TDM practices.

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Sampling time and indications appropriateness for therapeutically monitored drugs at a teaching university hospital in Oman

Za’abi

Muqbali

Al-Waili

2015

Saudi Pharmaceutical Journal

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Utilization Pattern of Vancomycin in a University Teaching Hospital in Oman: Comparison with International Guidelines

Abstract: Purpose: To assess the prescribing and utilization pattern of vancomycin in Sultan Qaboos UniversityHospital (SQUH)

Cited by 6 publications

References 16 publications

A new approach to Vancomycin utilization evaluation: A cross-sectional study in intensive care unit

A new approach to Vancomycin utilization evaluation: A cross-sectional study in intensive care unit

Vancomycin therapeutic drug monitoring service quality indices and clinical effectiveness outcomes: A retrospective cohort and clinical audit

Sampling time and indications appropriateness for therapeutically monitored drugs at a teaching university hospital in Oman

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