Utilizing a series of fac-Re(CO)3 core based quinonoid containing complexes for photophysical and cell imaging studies

Rhenium‐Carbonyl‐Based Supramolecular Coordination Complexes: Synthesis, Structure and Properties

“…Apart from anti‐cancer properties, the facial ‐Re(CO) 3 core containing complexes display biological activity for application in cell‐imaging, photodynamic therapy and membrane transport . The properties of facial ‐Re(CO) 3 core based bio‐active complexes can be easily tuned by varying the coordinated ligands ,. However, most of the biological studies based on facial ‐Re(CO) 3 complexes involve only acyclic complexes, there are very few reports on biological evaluations of Re metallacycles.…”

Redox Activity and Bond Activation in Iridium–Diamidobenzene Complexes: A Combined Structural, (Spectro)electrochemical, and DFT Investigation

“…In recent years, we have used the “NR” for “O” isolobal analogy to generate ligands and their metal complexes where we have investigated electronic structures as well as bond activation and formation reactions. ,,, The focus of this line of research has been on the potential use of the electron reservoir behavior of noninnocent ligands for performing chemical bond activation and formation at the metal center. In the context of o -diiminoquinones, we could recently show that a cobalt complex containing such a ligand can act as an (electro)­catalyst for C–C bond formation reactions, by making use of electrons from the noninnocent ligands .…”

Calix[4]arene-Analogous Technetium Supramolecules

“…The design and synthesis of stable and kinetically inert fac -[M­(CO) 3 ] + (M = 99m Tc/ 186/188 Re) core-based complexes have been gaining continuous research interest for the development of new radiopharmaceuticals as diagnostic and therapeutic agents. − 99m Tc is still the workhorse of nuclear diagnostics because of its ideal nuclear decay properties ( t 1/2 = 6.02 h, pure γ emitter, and E γ = 140 keV, 89%), whereas the β-emitting rhenium nuclides 188 Re ( t 1/2 = 17 h and E β = 2.12 MeV) and 186 Re ( t 1/2 = 89.3 h and E β = 1.07 MeV) have potential for therapy . Isostructural technetium and rhenium complexes are good candidates for nuclear medical theranostics, and procedures exist for the synthesis of aqua complexes [ 99m Tc/ 188 Re­(CO) 3 (H 2 O) 3 ] + as appropriate precursor molecules. ,,, Several attempts have been made toward the synthesis of organometallic technetium complexes using various types of heterocyclic ligands because of their importance in medicinal fields. − Recently, efforts have been directed toward the design and synthesis of fac -[Re­(CO) 3 ] + core-based metal–organic macrocycles, i.e., supramolecular coordination complexes or metallomacrocycles, because of their potential applications as bioimaging and anticancer agents. − …”

“…We envision that the synthesis of fac -[Tc­(CO) 3 ] + core-based macrocycles may result in a new class of supramolecules that may find potential utility in medicinal fields because of the combined properties of the technetium­(I) tricarbonyl core and discrete 2D/3D supramolecular structures. In general, the known synthetic approaches for making fac -[Re­(CO) 3 ] + core-based discrete supramolecules can be applied to create structurally analogous fac -[Tc­(CO) 3 ] + core-based supramolecules. − To the best of our knowledge, fac -[{Tc­(CO) 3 Cl} 2 (ptc) 2 ] [ptc = 4-pyridylthiosemicarbazone = C 6 H 5 N-C­(CH 3 )N-NH-C­(S)-NH 2 ], is the only known example for a metallomacrocycle based on the fac -[Tc­(CO) 3 ] + core . Here, we report fac -[Tc­(CO) 3 Cl] core-based supramolecules analogous to calix[4]­arenes.…”