2023
DOI: 10.3390/polym15214292
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Utilizing Drug Amorphous Solid Dispersions for the Preparation of Dronedarone per os Formulations

Afroditi Kapourani,
Alexandra-Eleftheria Manioudaki,
Konstantinos N. Kontogiannopoulos
et al.

Abstract: Dronedarone (DRN), an antiarrhythmic drug, exhibits potent pharmacological effects in the management of cardiac arrhythmias. Despite its therapeutic potential, DRN faces formulation challenges due to its low aqueous solubility. Hence, the present study is dedicated to the examination of amorphous solid dispersions (ASDs) as a strategic approach for enhancing the solubility of DRN. Initially, the glass forming ability (GFA) of API was assessed alongside its thermal degradation profile, and it was revealed that … Show more

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Cited by 3 publications
(2 citation statements)
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“…This measure was taken to enable a direct comparison carriers' effectiveness in preventing the precipitation of the supersaturated API. T lection of these parameters was based on previously published studies [42,61]. In the case where the precipitation of OLN was examined in the ternary systems (i.e., OLN-Syloid 244 FP in combination with coPVP or HPMC), according to our findings, a higher concentration of OLN was observed in the case of Syloid 244 FP-coPVP.…”
Section: Anti-precipitant Screening Using the Solvent Shift Methodsmentioning
confidence: 62%
See 1 more Smart Citation
“…This measure was taken to enable a direct comparison carriers' effectiveness in preventing the precipitation of the supersaturated API. T lection of these parameters was based on previously published studies [42,61]. In the case where the precipitation of OLN was examined in the ternary systems (i.e., OLN-Syloid 244 FP in combination with coPVP or HPMC), according to our findings, a higher concentration of OLN was observed in the case of Syloid 244 FP-coPVP.…”
Section: Anti-precipitant Screening Using the Solvent Shift Methodsmentioning
confidence: 62%
“…This measure was taken to enable a direct comparison of the carriers’ effectiveness in preventing the precipitation of the supersaturated API. The selection of these parameters was based on previously published studies [ 42 , 61 ].…”
Section: Resultsmentioning
confidence: 99%