Utilizing Intraluminal Pressure Gradients to Predict Esophageal Clearance: A Validation Study

Abstract

BACKGROUND-Esophageal bolus clearance requires a preferential esophagogastric pressure gradient sustained for a sufficient period. We aimed to validate a high-resolution manometry (HRM) paradigm for predicting bolus clearance.

The Value of High-Resolution Manometry in the Assessment of the Resting Characteristics of the Lower Esophageal Sphincter

“…9 To date, no studies have assessed the use of HRM in measuring the resting characteristics of the lower esophageal sphincter. In particular, the impact of the elimination of the "pullthrough" component of LES analysis has not been studied.…”

Impedance as an adjunct to manometric testing to investigate symptoms of dysphagia: What it has failed to do and what it may tell us in the future

“…1 The EGJ is a complex region demonstrating radial pressure asymmetries due to extrinsic structures 73,74 and this complexity has been shown to produce erroneous recordings of high pressure within the EGJ when at the same time bolus flow across the EGJ is evident on radiology. 75 The observation of a high EJG pressure is interpreted as representative of the restricted ability of contents to flow across the EGJ during deglutition. However, to our knowledge, published studies have not described a direct correlation between IRP4 and flow-time across the EGJ.…”

Dysphagia and Gastroesophageal Junction Resistance to Flow Following Partial and Total Fundoplication

“…[6][7][8] In the clinical setting, total fundoplication and possibly hiatal hernia alter intrabolus pressure. 5,9 Dysphagia is an intriguing symptom that is experienced prior to surgery by some patients with reflux disease in the absence of stricture and also by some patients after surgery. The physiology of both preoperative and postoperative dysphagia is poorly understood.…”