Purpose: This study aimed to clarify nursery school nurses' work engagement and their pertinent related factors. Method: We conducted a survey of 136 nursery school nurses using an anonymous, self-administered questionnaire. Questionnaires were distributed to 186 people at licensed daycare centers in Ibaraki Prefecture. The following conclusions were obtained by analyzing 136 participants, excluding deficiencies: A multiple regression analysis (forced entry method) was performed. Results: The survey results show that most of the nurses in the nursery school were female, about 90% were married, and about 70% had children. Work engagement was generally high compared with other occupations. Moreover, it was influenced by their work-self balance (positive), the meaning of their work, and the leadership of bosses. It was suggested that there is a need for an environment where nurses can maintain a work-life balance, a place where childcare health activities can be carried out, and opportunities to participate in training and liaison meetings for nursery nurses to further enhance work engagement. Conclusion: It was influenced by work self-balance (positive), the meaning of their work, and boss leadership. It is suggested that nursery nurses further enhance their work engagement, and they need an environment where they can maintain a work-life balance, a place where they can engage in health activities in childcare, and opportunities for training and liaison meetings.