UV‐C‐irradiation sublethal stress does not alter antibiotic susceptibility of the viridans group streptococci to β‐lactam, macrolide, and fluoroquinolone antibiotic agents

Maeda, Yasunori; Coulter, Wilson A.; Goldsmith, Colin E.; Millar, B. Cherie; Moore, John E.

doi:10.1111/j.2041-1626.2011.00100.x

Cited by 4 publications

(4 citation statements)

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“…S. acidominimus has generally been believed to be sensitive to beta-lactam [9], as observed in the previous seven cases. However, in our five cases, there was increased resistance to beta-lactams, with two out of five being resistant.…”

Section: Discussionmentioning

confidence: 87%

Streptococcus acidominimus causing invasive disease in humans: a case series

Liang

Gong

et al. 2014

J Med Case Reports

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IntroductionStreptococcus acidominimus is a member of the viridans group streptococci and is rarely pathogenic in humans, making it difficult to assess its epidemiologic and clinical significance.Case presentationWe report the cases of five Han Chinese patients with invasive diseases caused by S. acidominimus over a one-year time frame. Three of the patients developed continuous fever after surgery, consisting of a successful elective laparoscopic cholecystectomy (case 1), a laparoscopic esophageal resection and gastroesophageal anastomosis (case 2), and a liver transplant in a patient with liver cancer (case 3). For these three patients, cultures of the purulent drainage material grew S. acidominimus. Case 4 concerns a 52-year-old man who developed sepsis 48 hours after hospitalization for hepatitis, liver cirrhosis and hepatitis-related glomerulonephritis. Case 5 concerns a 55-year-old woman receiving regular hemodialysis who had low-grade fever for one month. For these two patients, blood cultures grew S. acidominimus. An antimicrobial susceptibility test revealed that S. acidominimus was resistant to clindamycin and, to some degree, beta-lactam or macrolides. The S. acidominimus from the patient on hemodialysis was resistant to multiple antibiotics.ConclusionS. acidominimus is an ever-increasing cause of disease, especially in patients who are critically ill. It is showing increased resistance to antimicrobial agents, so in patients with viridans group streptococci infections, it is necessary to identify the species to improve the clinical management of S. acidominimus.

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Section: Discussionmentioning

confidence: 87%

Streptococcus acidominimus causing invasive disease in humans: a case series

Liang

Gong

et al. 2014

J Med Case Reports

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“…Thus, a new microbiocidal surgical method that does not evoke formation of resistances is desirable. Therefore, the application of UVC radiation is a suitable and promising alternative 8 .…”

Section: Introductionmentioning

confidence: 99%

Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models

Zwicker

Schleusener

Lohan

et al. 2022

Sci Rep

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A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280–380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm2, the 233 nm light source reduced the viable microorganisms by a log10 reduction (LR) of 5 log10 levels if no soil load was present. Mucin and protein containing soil loads diminished the effect to an LR of 1.5–3.3. A salt solution representing artificial sweat (pH 8.4) had only minor effects on the reduction. The viability of the skin models was not reduced and the DNA damage was far below the damage evoked by 0.1 UVB minimal erythema dose, which can be regarded as safe. Furthermore, the induced damage vanished after 24 h. Irradiation on four consecutive days also did not evoke DNA damage. The radical formation was far lower than 20 min outdoor visible light would cause, which is classified as low radical load and can be compensated by the antioxidant defence system.

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“…Estas modificaciones producen distorsiones en la forma del ADN interfiriendo en el apareamiento normal de las bases, y como resultado se bloquea la síntesis de ADN, afectando las funciones celulares y pudiendo provocar la muerte. Los efectos en los enlaces cruzados son proporcionales al tiempo de exposición e intensidad de la luz UV (Maeda et al, 2012).…”

Section: Irradiaciónunclassified

HACCP en plantas artesanales pequeñas y medianas dedicadas a la producción de hortalizas de IV y V Gama*

et al. 2016

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La oferta de alimentos frescos mínimamente procesados está creciendo, por lo que resulta indispensable que dichos productos puedan ser utilizados sin riesgos para la salud de los consumidores. Estos riesgos pueden repercutir no solamente en serios efectos en la salud del hogar y en la productividad de las empresas, sino incluso en responsabilidades legales de las empresas productoras. El número de plantas de procesamiento de hortalizas en las diferentes escalas se ha incrementado durante los últimos años en muchos países. Al mismo tiempo, los productos vegetales frescos han sido implicados en diferentes investigaciones como principal fuente de infección. Además, la manipulación durante el procesamiento y la falta de tratamientos térmicos hace que los puntos de control del riesgo en su proceso sean difíciles de establecer. Es por eso que en esta revisión se destaca la importancia de la implementación de programas efectivos como las buenas prácticas de manufactura (BPM), los procedimientos estándares operativos de saneamiento (PEOS) y el análisis de peligros y puntos críticos de control (HACCP) que ayuden a asegurar la inocuidad de estos alimentos. Palabras clave: inocuidad, vegetales frescos cortados, desinfección The supply of minimally processed fresh foods is growing, so it is essential that the products can be used without risk to the health of consumers. Such risks can result not only in serious effects on home health and business productivity, but even in legal responsibilities for producers. The number of vegetable processing plants in different scales has increased in recent years in many countries. At the same time, fresh plant products have been involved in various researches as the main source of infection. Also, handling during processing and lack of heat treatment turn risk control points during the process difficult to establish. For this reason, this review highlights the importance of effective programs implementing Good Manufacturing Practices (GMP), Sanitation Standar Operating Procedures (SSOP) and Hazard Analysis and Critical Control Point (HACCP) which aid in assuring the safety of these foods.

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UV‐C‐irradiation sublethal stress does not alter antibiotic susceptibility of the viridans group streptococci to β‐lactam, macrolide, and fluoroquinolone antibiotic agents

Abstract: Exposure to UV-C light will not result in altered antibiotic susceptibility patterns on viridans group streptococci. Given that UV-C is more toxic and mutagenic than UV-A light, it is unlikely than UV-A light would yield any difference in response to such exposure.

Cited by 4 publications

References 10 publications

Streptococcus acidominimus causing invasive disease in humans: a case series

Streptococcus acidominimus causing invasive disease in humans: a case series

Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models

HACCP en plantas artesanales pequeñas y medianas dedicadas a la producción de hortalizas de IV y V Gama*

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