UV Filters, Ingredients with a Recognized Anti-Inflammatory Effect

Couteau, Céline; Chauvet, Catherine; Paparis, Eva; Coiffard, Laurence

doi:10.1371/journal.pone.0046187

Cited by 47 publications

(27 citation statements)

References 24 publications

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“…These findings are consistent with those from a study in mice that reported inhibition of edema, an anti-inflammatory effect, associated with topical BP-3 application (Couteau et al, 2012). To our knowledge, no studies have examined associations between parabens and inflammation in general, or CRP specifically.…”

Section: Discussionsupporting

confidence: 92%

“…Animal studies suggest that BP-3 is weakly estrogenic and antiandrogenic (Krause et al, 2012), but health effects related to BP-3 exposure in humans have not been studied. In in vitro studies, BP-3 has been associated with markers of oxidative stress (Gao et al, 2013; Kato et al, 2006), but findings from an animal study suggested that BP-3 may have anti-inflammatory properties (Couteau et al, 2012)…”

Section: Introductionmentioning

confidence: 99%

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Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Watkins

Ferguson

Toro

et al. 2015

International Journal of Hygiene and Environmental Health

196

112

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Phenols and parabens are used in a multitude of consumer products resulting in ubiquitous human exposure. Animal and in vitro studies suggest that exposure to these compounds may be related to a number of adverse health outcomes, as well as potential mediators such as oxidative stress and inflammation. We examined urinary phenol (bisphenol A (BPA), triclosan (TCS), benzophenone-3 (BP-3), 2,4-dichlorophenol (24-DCP), 2,5-dichlorophenol (25-DCP)) and paraben (butyl paraben (B-PB), methyl paraben (M-PB), propyl paraben (P-PB)) concentrations measured three times during pregnancy in relation to markers of oxidative stress and inflammation among participants in the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) project. Serum markers of inflammation (c-reactive protein (CRP), IL-1β, IL-6, IL-10, and tumor necrosis factor-α (TNF-α)) were measured twice during pregnancy (n=105 subjects, 187 measurements) and urinary markers of oxidative stress (8-hydroxydeoxyguanosine (OHdG) and isoprostane) were measured three times during pregnancy (n=54 subjects, 146 measurements). We used linear mixed models to assess relationships between natural log-transformed exposure and outcome biomarkers while accounting for within individual correlation across study visits. After adjustment for urinary specific gravity, study visit, maternal pre-pregnancy BMI, and maternal education, an interquartile range (IQR) increase in urinary BPA was associated with 21% higher OHdG (p=0.001) and 29% higher isoprostane (p=0.0002), indicating increased oxidative stress. The adjusted increase in isoprostane per IQR increase in marker of exposure was 17% for BP-3, 27% for B-PB, and 20% for P-PB (all p<0.05). An IQR increase in triclosan (TCS) was associated with 31% higher serum concentrations of IL-6 (p=0.007), a pro-inflammatory cytokine. In contrast, IQR increases in BP-3 and B-PB were significantly associated with 16% and 18% lower CRP, a measure of systemic inflammation. Our findings suggest that exposure to BPA, select parabens, and TCS during pregnancy may be related to oxidative stress and inflammation, potential mechanisms by which exposure to these compounds may influence birth outcomes and other adverse health effects, but additional research is needed.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Watkins

Ferguson

Toro

et al. 2015

International Journal of Hygiene and Environmental Health

196

112

View full text Add to dashboard Cite

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“…However, a previous study revealed that acetylsalicylic acid had no effect on MS (7,8). On the other hand, homosalate suppressed the ear edema response to dinitrobenzene (9). Because NSAIDs are well-known inhibitors of cyclooxygenase (COX) (10), and COX-2 has been observed in MS lesions (11), a possible mechanism of action of the salicylates is suppression of COX.…”

Section: Discussionmentioning

confidence: 99%

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

Wang

Marling

Plum

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV radiation. Furthermore, various sunblock preparations had variable ability to suppress EAE. By examining the components of the most effective agents, we identified homosalate and octisalate as the components responsible for suppressing EAE. Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease.

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“…It is known from the literature that UV filters have anti-inflammatory effects. Diethyhexyl butamido triazone and benzophenone-5, in particular, have substantial anti-inflammatory properties, which have also been reported for homosalate, benzophones, and cinnamic acid derivates [11]. Furthermore, the sunscreen agents oxybenzone and dioxybenzone have been patented as anti-inflammatory agents [12].…”

Section: Discussionmentioning

confidence: 99%

Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo

Werner

Herling²,

Garbe³

et al. 2017

Skin Pharmacol Physiol

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Background: Today, the sun protection factor (SPF) value of sunscreen products is determined in vivo with a standardized protocol (EN ISO 24444:2010), and the measured SPF biological end point is the visible skin erythema. However, many of the sunscreen products currently available on the market have antiphlogistic ingredients, which may potentially result in an overestimated SPF of the sunscreen. Aims: To investigate the potential influence of the antiphlogistic ingredients panthenol and bisabolol in sunscreens on the determined SPF value in vivo. Methods: Formulations with different concentrations of the antiphlogistic ingredients bisabolol or panthenol were tested. As a reference, a base formulation (vehicle) without antiphlogistic ingredients was used. First, the SPF of the sunscreen formulas with and without antiphlogistic ingredients was analyzed in vitro. To investigate whether the antiphlogistic ingredient may suppress the inflammatory response to ultraviolet (UV) irradiation, the SPF was determined in vivo. Finally, selected formulations were also analyzed in an erythema model for testing formulations on UV-induced inflammation. Results: It could be confirmed that no differences between the formula with and that without the active antiphlogistic ingredients bisabolol or panthenol exist when measured in vitro. However, there was also no statistically significant difference in the erythemal response between the vehicle (without an antiphlogistic active ingredient) and the test formulations with different concentrations of the antiphlogistic active ingredients in the in vivo determination of the SPF. Evidence of anti-inflammatory activity of the sunscreen antiphlogistics bisabolol and panthenol was also not apparent in the UV model over a time course of 48 h. Conlusion: The antiphlogistic ingredients panthenol and bisabolol incorporated in the tested sunscreen formula do not interfere with erythema reddening and thus do not affect the SPF value in vivo.

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UV Filters, Ingredients with a Recognized Anti-Inflammatory Effect

Cited by 47 publications

References 24 publications

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo

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