UV-Initiated Crosslinking of Poly(ethylene oxide) with Pentaerythritol Triacrylate in Solid State

Doytcheva, Maria; Dotcheva, Dobrinka; Stamenova, Rayna; Tsvetanov, Christo B.

doi:10.1002/1439-2054(20010101)286:1<30::aid-mame30>3.0.co;2-6

Cited by 34 publications

(29 citation statements)

References 2 publications

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“…As the concentration of PETA increases the main NEXAFS peak shifts to lower energy and the spectral line shape transitions from mainly PEO (1.5% wt-PETA sample) to mainly PETA (10 wt-% PETA sample). Doytcheva et al suggested that under UV irradiation, PETA (singlet) undergoes an intersystem crossing to form an excited triplet state which is capable of cleaving a proton from PEO to form a PEO radical and a PETA radical [10]. Our experiments verify that PETA acts as both an initiator and a crosslinker since UV irradiation of PEO alone does not form crosslinked PEO.…”

Section: Resultssupporting

confidence: 75%

“…UV-initiated crosslinking of PEO with pentaerythritol triacrylate (PETA) or other radical crosslinkers [8] is becoming increasingly popular since PEO can be crosslinked in both solution and solid state [9,10]. The inclusion of PETA to form crosslinked PEO has been used in biomedical applications such as hydrogels [11,12] and micelles [13] for drug delivery, or to form chemically patterned surfaces for cell studies [14].…”

Section: Introductionmentioning

confidence: 99%

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X-ray Spectromicroscopy Study of Protein Adsorption to a Polystyrene−Polylactide Blend

et al. 2009

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Abstract:Synchrotron-based X-ray photoemission electron microscopy (X-PEEM) was used to characterize the near surface composition of polyethylene oxide (PEO) combined with 1.5, 5, and 10 wt-% pentaerythritol triacrylate (PETA) cross-linker. It was found that as the concentration of PETA increased, it became the dominant component in the top 10 nm of the film surface. The same surfaces were also exposed to human serum albumin (HSA) and the distributions of the protein relative to PEO and PETA were measured with X-PEEM. A positive correlation was found between levels of PETA and HSA at the surface. Above PETA concentrations of 5 wt-%, HSA adsorption was significant, which suggests high levels of PETA (often used to immobilize PEO by cross-linking) can significantly reduce the non-fouling properties of PEO.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

X-ray Spectromicroscopy Study of Protein Adsorption to a Polystyrene−Polylactide Blend

et al. 2009

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“…Upon absorption of a photon with a wavelength of 250–365 nm, they transform via a photophysical processes (the ground state is excited to a single state that rapidly decays to a reactive triplet state) and can abstract aliphatic hydrogen . It was previously shown that UV irradiation of high or low molar mass PEO , its aqueous solutions or PEO/PVP blends in the presence of benzophenone or its derivatives led to polymer crosslinking and thus to network formation.…”

Section: Resultsmentioning

confidence: 99%

“…Direct UV irradiation of poly(ethylene oxide) (PEO) in the presence of photosensitizers has also been studied. Solid high or low molar mass PEO in bulk and in aqueous solutions and PEO blends with PVP or poly( N ‐isopropylacrylamide) (PNIPAM) were UV crosslinked in the presence of benzophenone, (4‐benzoylbenzyl)trimethylammonium chloride or pentaerythritol triacrylate. Appropriate crosslinking conditions, such as photosensitizer content, irradiation time and temperature, were applied to determine their influence on the crosslinking density and thus the swelling properties of the final gels.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinking of Polyglycidol and Its Derivative: Route to Thermoresponsive Hydrogels

Utrata-Wesołek

Żymełka-Miara

Kowalczuk

et al. 2017

Photochem & Photobiology

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Hydrogels of biologically well-tolerated, high-molar-mass polyglycidol (PGl) and its thermoresponsive derivative poly(glycidol-co-ethyl glycidyl carbamate) have been obtained by direct UV crosslinking in the solid state. Polymers with molar masses up to 1.45 × 10 g mol were crosslinked in the presence of benzophenone or (4-benzoylbenzyl)trimethylammonium chloride as photosensitizers. The photosensitizer concentration was varied from 2 to 10 wt%. The influence of polymer composition and photosensitizer type and amount on the crosslinking efficiency, swelling and temperature behavior of the obtained hydrogels was investigated. The photocrosslinking of PGl and poly(glycidol-co-ethyl glycidyl carbamate) led to hydrogels with swelling degrees up to 1700%. The swelling degrees of the hydrogels decreased with the increase of the environmental temperature indicating the thermoresponsive nature of gels. The swelling of obtained gels can be controlled by varying the composition of the copolymer precursor and by the network density.

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“…Since PEO is hydrophilic, techniques such as γ [80], UV [81,82] and electron irradiation [83] have been used to crosslink the PEO chains to prevent dissolution upon protein exposure. In particular, UV-initiated crosslinking of PEO with radical crosslinkers such as pentaerythritol triacrylate (PETA) [84,85] is becoming increasingly common for biomedical applications such as drug delivery [86,87] or to chemically pattern surfaces for cell studies [88]. …”

Section: Resultsmentioning

confidence: 99%

Characterization of Biomaterials by Soft X-Ray Spectromicroscopy

2010

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Synchrotron-based soft X-ray spectromicroscopy techniques are emerging as useful tools to characterize potentially biocompatible materials and to probe protein interactions with model biomaterial surfaces. Simultaneous quantitative chemical analysis of the near surface region of the candidate biomaterial, and adsorbed proteins, peptides or other biological species can be obtained at high spatial resolution via scanning transmission X-ray microscopy (STXM) and X-ray photoemission electron microscopy (X-PEEM). Both techniques use near-edge X-ray absorption fine structure (NEXAFS) spectral contrast for chemical identification and quantitation. The capabilities of STXM and X-PEEM for the analysis of biomaterials are reviewed and illustrated by three recent studies: (1) characterization of hydrophobic surfaces, including adsorption of fibrinogen (Fg) or human serum albumin (HSA) to hydrophobic polymeric thin films, (2) studies of HSA adsorption to biodegradable or potentially biocompatible polymers, and (3) studies of biomaterials under fully hydrated conditions. Other recent applications of STXM and X-PEEM to biomaterials are also reviewed.

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UV-Initiated Crosslinking of Poly(ethylene oxide) with Pentaerythritol Triacrylate in Solid State

Cited by 34 publications

References 2 publications

X-ray Spectromicroscopy Study of Protein Adsorption to a Polystyrene−Polylactide Blend

X-ray Spectromicroscopy Study of Protein Adsorption to a Polystyrene−Polylactide Blend

Photocrosslinking of Polyglycidol and Its Derivative: Route to Thermoresponsive Hydrogels

Characterization of Biomaterials by Soft X-Ray Spectromicroscopy

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