UV laser-processed microstructure for building biohybrid actuators with anisotropic movement

Mita, Hiroaki; Mizuno, Yosuke; Tanaka, Hiroto; Fujie, Toshinori

doi:10.1088/1758-5090/ad2080

Cited by 3 publications

References 61 publications

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Generation mechanism and anti-friction effect evaluation of continuous micro-groove texture machined by ball-end milling process

Huang,

et al. 2024

Surf. Topogr.: Metrol. Prop.

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The tool path in ball-end milling process is flexible and controllable considering the structure characteristics and moving way of the cutter. This paper aims to reveal the generation method of continuous surface micro-groove texture by using ball-end milling process and evaluate the corresponding anti-friction performance by combining simulation and friction experiments. Results indicate that continuous micro-grooved surface texture can be obtained by combining small feed per tooth and large radial cutting depth. Radial depth of cut and tool radius affect aspect ratio of micro-groove. The bearing capacity of the oil film shows an increasing and then decreasing trend with the increase of radial depth of cut and orientation angle. Radial depth of cut increased from 0.1 mm to 0.3 mm, resulting in a maximum 4.87% increase in the bearing capacity of oil film because of the enhanced wedge effect. However, further increase in radial depth of cut leads to increased vortex, weakening the wedge effect. The oil film bearing capacity is reduced so that the friction coefficient increases by a maximum of 510%. Moreover, as the orientation angle increases from 10° to 20°, the bearing capacity of the oil film increases by 22.7%. The minimum friction coefficient currently is 0.0215. However, when the micro-groove orientation angle is further increased, the countercurrent effect is enhanced and the dynamic pressure effect is weakened, which finally leads to a decrease in the bearing capacity of the oil film. The friction coefficient has increased by 30.2% maximum. This study is of great significance which provides a new method for guiding the friction reduction on the die surface.

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Generation mechanism and anti-friction effect evaluation of continuous micro-groove texture machined by ball-end milling process

Huang,

et al. 2024

Surf. Topogr.: Metrol. Prop.

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Leveraging microtopography to pattern multi-oriented muscle actuators

Rossy,

Schwendeman,

Bawa

et al. 2024

Preprint

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Engineering skeletal muscle tissue with precisely defined alignment is of significant importance for applications ranging from drug screening to biohybrid robotics. Aligning 2D contractile muscle monolayers, which are compatible with high-content imaging and can be deployed in planar soft robots, typically require micropatterned cues. However, current protocols for integrating microscale topographical features in extracellular matrix hydrogels require expensive microfabrication equipment and multi-step procedures involving error-prone manual handling steps. To address this challenge, we present STAMP (Simple Templating of Actuators via Micro-topographical Patterning), an easily accessible and cost-effective one-step method to pattern microtopography of various sizes and configurations on the surface of hydrogels using reusable 3D printed stamps. We demonstrate that STAMP enables precisely controlling the alignment of mouse and human skeletal muscle fibers, and thus their force-generating axes, without impacting their maturation or function. To showcase the versatility of our technique, we designed a planar soft robot inspired by the iris, which leverages spatially segregated regions of concentric and radial muscle fibers to control pupil dilation. Optogenetic skeletal muscle fibers grown on a STAMPed iris substrates formed a multi-oriented actuator, and selective light stimulation of the radial and concentric fibers was used to control the function of the iris, including pupil constriction. Computational modeling of the biohybrid robot as an active bilayer matched experimental outcomes, showcase the robustness of our method of designing, fabricating, and testing planar biohybrid robots capable of complex multi-degree-of-freedom motion.

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