UV‐Light‐Irradiated Trifluoromethylation of Diheteroaryl Disulfides with CF₃SO₂Na

Abstract

A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) has been developed. The features of simple and clean reaction conditions, in moderate to good yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially pharmaceutically active compounds.

Chemoselective Perfluoromethylation of Thio- and Selenoamides

“…In this context, different strategies and reagents had been developed to introduce SCF 3 groups directly and indirectly. , Among these, the inexpensive and stable CF 3 SO 2 Na was widely used as the CF 3 source in the trifluoromethylation (CF 3 lation) protocol that reacts with thiophenols and disulfides to generate the corresponding SCF 3 moiety pioneered by the Langlois group (Figure a) . Direct trifluoromethylthiolation of nonprefunctionalized heterocycles is uncommon not to mention the elusive trifluoromethylselenolation using CF 3 SO 2 Na .…”