UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon

Bardajee, Ghasem Rezanejade; Pourjavadi, Ali; Ghavami, Somayeh; Soleyman, Rouhollah; Jafarpour, Farnaz

doi:10.1016/j.jphotobiol.2010.12.008

Cited by 40 publications

(10 citation statements)

References 27 publications

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“…A hydrogel can be defined as a three-dimensional network of a hydrophilic polymer that can absorb and retain large amounts of water within its network [ 1 ]. In order to maintain the structures of hydrogel networks in aqueous solution and prevent their dissolution, the development of either a physical or chemical cross-linking method was necessary [ 2 ]. To date, hydrogels have been developed for application in a range of fields, including personal hygiene products, and in biomedical, pharmaceutical, and mechanical engineering [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Swelling Behavior of pH-Sensitive Semi-IPN Superabsorbent Hydrogels Based on Poly(acrylic acid) Reinforced with Cellulose Nanocrystals

et al. 2017

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pH-sensitive poly(acrylic acid) (PAA) hydrogel reinforced with cellulose nanocrystals (CNC) was prepared. Acrylic acid (AA) was subjected to chemical cross-linking using the cross-linking agent MBA (N,N-methylenebisacrylamide) with CNC entrapped in the PAA matrix. The quantity of CNC was varied between 0, 5, 10, 15, 20, and 25 wt %. X-ray diffraction (XRD) data showed an increase in crystallinity with the addition of CNC, while rheology tests demonstrated a significant increase in the storage modulus of the hydrogel with an increase in CNC content. It was found that the hydrogel reached maximum swelling at pH 7. The potential of the resulting hydrogels to act as drug carriers was then evaluated by means of the drug encapsulation efficiency test using theophylline as a model drug. It was observed that 15% CNC/PAA hydrogel showed the potential to be used as drug carrier system.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Swelling Behavior of pH-Sensitive Semi-IPN Superabsorbent Hydrogels Based on Poly(acrylic acid) Reinforced with Cellulose Nanocrystals

et al. 2017

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“…Shorter exposure time makes monomer has no enough time to react, which cause incomplete polymerization, resulting in low absorption rate. Since UV rays play the role of initiators, longer exposure time will create macroradicals, making too intensive crosslinking density and resulting in the low absorption rate. Apparently, the optimum polymerization time is 45 min.…”

Section: Resultsmentioning

confidence: 99%

Ultraviolet photopolymerization and performances of fast‐water absorbing sodium polyacrylate

Dolat

Sawut

Yimit

et al. 2015

J of Applied Polymer Sci

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A kind of fast-water absorbing sodium polyacrylate was prepared by UV polymerization under no crosslinker or initiator condition. Influence of factors, such as exposure time, neutralization degree, polymerization temperature, and monomer concentration on the absorption rate of the resin, were investigated. Its pH sensitivity, average absorption rate in distilled water and saline under load were also studied, respectively. The obtained resin reached to considerably high absorption rate: 4.6 g/g min and 2.6 g/g min even under 8000 Pa load in distilled water and 0.9% NaCl solution, respectively. Simultaneously, the resin displayed excellent water absorbency and water retention capacity. The impact of pH value on absorption rate reflected that the absorption rate was greatly influenced by pH. Synthesized polymer was characterized by FTIR, 1 H-NMR, and SEM.

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“…It presents a tetrasaccharide repeating sequence of glucose (Glc), glucuronic acid (ClcA) and rhamnose (Rha) residues in a 2:1:1 ratio linked together to form the linear primary structure [D-Glc(β1→4)D-GlcA(β1→4)D-Glc(β1→4)L-Rha(α1→3)]n [17]. One of the advantages of gellan is that it is stable through a wide pH range [18,19]. It forms gel at concentrations remarkably lower than other hydrocolloids such as carrageenan, alginate, pectin or gelatine [16].…”

Section: Manuscriptmentioning

confidence: 99%

Gellan Hydrogels: Preparation, Rheological Characterization and Application in Encapsulation of Curcumin

et al. 2019

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Hydrogels can be used to protect some labile active principles, as polyphenol-rich substances, that can be added to foods to prepare functional ones. Rheological properties of gels formed through the addition of calcium chloride to gellan solutions were studied. It can be concluded that preparation variables and not only formulation ones are determinant in rheological properties of the resulting gels, as they are not in an equilibrium state but they are continuously evolving during hours to stronger gels corresponding to a denser network. It could be related to the fact that local non-gelled domains are formed surrounded by a shell of gel where Ca 2+ ions take some time to arrive. A minimum Ca 2+ /gellan ratio (CG) is required to reach the gel point (GP), determined as the CG where the ratio loss modulus/elastic modulus (G"/G') collapse for all frequencies. Calcium-induced external gelation of oil-in-water (O/W) emulsions where a curcumin-in-oil solution is the disperse phase and a watery solution of gellan is the continuous phase was used to prepare beads were curcumin is entrapped in order to prevent its degradation. Smaller droplet-sized emulsions were obtained with higher gellan concentrations, since a higher viscosity of the continuous phase allowed to reach the critical Capillary number CaC at lower radius of droplets. An encapsulation yield around 90 % was reached for gellan concentrations of 1 % w/v, and the resulting encapsulated curcumin presented around 6 times slower light degradation than free curcumin-inoil solutions.

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UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon

Cited by 40 publications

References 27 publications

Synthesis and Swelling Behavior of pH-Sensitive Semi-IPN Superabsorbent Hydrogels Based on Poly(acrylic acid) Reinforced with Cellulose Nanocrystals

Synthesis and Swelling Behavior of pH-Sensitive Semi-IPN Superabsorbent Hydrogels Based on Poly(acrylic acid) Reinforced with Cellulose Nanocrystals

Ultraviolet photopolymerization and performances of fast‐water absorbing sodium polyacrylate

Gellan Hydrogels: Preparation, Rheological Characterization and Application in Encapsulation of Curcumin

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