Uv-Spectrophotometric Stability Indicating Methods for the Quantitative Determination of Cimetidine, Famotidine, and Ranitidine Hydrochloride in the Presence of Their Oxidative Derivatives

Abstract

Simple, sensitive and rapid spectrophotometric techniques have been established for the determination of cimetidine (I), famotidine (II) and ranitidine hydrochloride (III) in presence of their S-oxide derivatives in both raw materials and in pharmaceutical formulations. Hydrogen peroxide was used to enhance the formation of S-oxide compounds (oxidative derivatives). The first derivative of the ratio spectra ( 1 DD) technique has been applied for the determination of (I) and (II). While, direct zero order ( 0 D), first derivative ( 1 D) and the second derivative of the ratio spectra ( 2 DD) have been carried out for the determination of drug (III). Linear calibration 1055 curves were obtained for determination of (I) and (II) by applying 1 DD at 220 and 230 nm in the concentration range of 2-20 and 4-40 mg mL À1 with the mean percentage recoveries of 99.88 AE 0.943 (n ¼ 10) and 99.88 AE 0.824% (n ¼ 10) for (I) and (II), respectively. While for (III) linear calibration curves were obtained by applying 0 D, 1 D and 2 DD at 313, 334 and 255 nm, respectively. The concentration range was 2-20 mg mL À1 with the corresponding mean percentage recoveries of 100.13 AE 0.464, 100.01 AE 0.428 and 99.94 AE 0.439 for (I), (II) and (III), respectively. The results obtained by the proposed methods were statistically analyzed and compared with those obtained by the official BP methods.

Instrumental analysis of some anti-ulcer drugs in different matrices

“…Direct zero order, first derivative and the second derivative of the ratio spectra had been carried out for the determination of the drug. [6] Spectrophotometric method was developed for determination of ranitidine through its oxidation by a known excess of bromate in acid medium and in the presence of excess bromide followed by estimation of surplus oxidant by reacting with either indigo carmine or metanil yellow and measuring the absorbance at λ max 610 or 530 nm. [7] Potassium iodate and 2,7-dichlorofluorescein were used for spectrophotometric determination of ranitidine.…”

“…Based on the chemiluminescence intensity generated from the potassium ferricyanide [K (3) Fe(CN) (6) ]rhodamine 6G system in sodium hydroxide medium, a flow-injection chemiluminescence (FI-CL) method had been developed, validated and applied for the determination of ranitidine HCl. [31] Ranitidine HCl was determined potentiometrically through construction of ion-selective electrodes.…”

Determination of Chemical Stability of Various Famotidine Dosage Forms by UV –Visible Spectrophotometric Method and Data Analysis by R-GUI Stability Software

“…Several degradation products were obtained and structures established by proton and carbon NMR, Mass spectroscopy [17]. UV/Visible stability demonstrating method for evaluation of Famotidine, Cimetidine and Ranitidine Hydrochloride in existence of their derivative was adopted by Kelani et al, in 2002 [18].…”

HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products

“…For the determination of famotidine in pharmaceutical preparations as well as in biological fluids, several types of analytical methods have been reported in the specialty literature: colorimetric [14][15][16], potentiometric [17], voltammetric [18], capillary electrophoresis [19][20][21], spectrophotometric [22][23][24][25][26], thin layer chromatography [27][28][29] and HPLC [30][31][32][33][34][35][36]. HPLC methods allow simultaneous determination of famotidine with other pharmaceutical substances in multicomponent preparations and in biological media [34,36].…”