UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk, Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies

Akhtar, Faiza; Gul, Somia; Ashfaq, Salman; Rehman, Iqra; Mirza, Agha Zeeshan

doi:10.1007/s41664-020-00146-9

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…It is a drug administered for the treatment of type 2 diabetes mellitus. [1][2][3] Glibenclamide has an acute hypoglycemic inuence as it acts on pancreatic beta cells and stimulates insulin secretion, leading to the cells of the organism to enhance their glucose consumption. 3 It is one of the two important oral antidiabetic medications (together with metformin) that have been recognized by the World Health Organization.…”

Section: Glibenclamide (Glb) 5-chloro-n-[2-[4-[[[(cyclohexylamino) Ca...mentioning

confidence: 99%

Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector

Sabbaghi,

Dadfarnia,

Haji Shabani

et al. 2024

RSC Adv.

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Section: Glibenclamide (Glb) 5-chloro-n-[2-[4-[[[(cyclohexylamino) Ca...mentioning

confidence: 99%

Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector

Sabbaghi,

Dadfarnia,

Haji Shabani

et al. 2024

RSC Adv.

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“…Up to now, many methods have been developed for detecting CIP, including high‐performance liquid chromatography [10, 11], liquid chromatography–tandem mass spectrometry [12, 13], fluorescence spectroscopy [14], electrochemical methods [15, 16], electrochemiluminescence [17], immunoassays [18], and so forth [19–21]. Among them, the advantages of using fluorescence methods for CIP detection lie in their high sensitivity, selectivity, real‐time monitoring capabilities, adaptability to various formats, relatively simple operation process, and low cost.…”

Section: Introductionmentioning

confidence: 99%

“…fluorescence spectroscopy [14], electrochemical methods [15,16], electrochemiluminescence [17], immunoassays [18], and so forth [19][20][21]. Among them, the advantages of using fluorescence methods for CIP detection lie in their high sensitivity, selectivity, real-time monitoring capabilities, adaptability to various formats, relatively simple operation process, and low cost.…”

mentioning

confidence: 99%

A ternary nucleotide–lanthanide coordination nanoprobe for ratiometric fluorescence detection of ciprofloxacin

Weng,

Li,

Liu

et al. 2024

Luminescence

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Ciprofloxacin (CIP) is a widely used broad‐spectrum antibiotic and has been associated with various side effects, making its accurate detection crucial for patient safety, drug quality compliance, and environmental and food safety. This study presents the development of a ternary nucleotide–lanthanide coordination nanoprobe, GMP‐Tb‐BDC (GMP: guanosine 5′‐monophosphate, BDC: 2‐amino‐1,4‐benzenedicarboxylic acid), for the sensitive and ratiometric detection of CIP. The GMP‐Tb‐BDC nanoprobe was constructed by incorporating the blue‐emissive ligand BDC into the Tb/GMP coordination polymers. Upon the addition of CIP, the fluorescence of terbium ion (Tb3+) was significantly enhanced due to the coordination and fluorescence sensitization properties of CIP, while the emission of the BDC ligand remained unchanged. The nanoprobe demonstrated good linearity in the concentration range of 0–10 μM CIP. By leveraging mobile phone software to analyze the color signals, rapid on‐site analysis of CIP was achieved. Furthermore, the nanoprobe exhibited accurate analysis of CIP in actual drug and milk samples. This study showcases the potential of the GMP‐Tb‐BDC nanoprobe for practical applications in CIP detection.

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“…The 4-oxo-3 carboxylic acid group is necessary for antimicrobial activity because it mediates the attachment to the DNA-gyrase complex. [3] Several techniques for determining GFX in pharmaceutical preparations or human plasma have been published including spectrophotometry, [4,5] spectrofluorimetry, [6] electrochemical method, [7] capillary electrophoresis, [8] HPLC. [9][10][11][12] Gatifloxacin (GTF) is chemically named as: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1 -piperazinyl)-4-oxo-3-quinoline carboxylic.…”

Section: Introductionmentioning

confidence: 99%

“…Several techniques for determining GFX in pharmaceutical preparations or human plasma have been published including spectrophotometry, [ 4,5 ] spectrofluorimetry, [ 6 ] electrochemical method, [ 7 ] capillary electrophoresis, [ 8 ] HPLC. [ 9–12 ]…”

Section: Introductionmentioning

confidence: 99%

Multiple sensitive eco‐friendly analytical approaches for the determination of two fourth‐generation fluoroquinolones: Application to stability study and content uniformity testing

Gammal

El‐Wasseef

El‐Ashry

et al. 2022

J Chinese Chemical Soc

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Multiple sensitive eco-friendly analytical techniques were applied for the assessment of two important fourth-generation fluoroquinolones namely, gemifloxacin (GFX), and gatifloxacin (GTF). GFX, which is utilized as an essential adjunct therapy for the management of pneumonia in SARS-CoV-2 was determined by green indicating micellar liquid chromatographic in authentic powder and dosage forms. The separation was performed by using a reversed-phase C 18 column; the micellar mobile phase comprised of 12.5% npropanol, 0.15 M sodium lauryl sulfate, and 0.3% triethylamine in 0.02 M Ophosphoric acid adjusted to pH 3.0 and pumped at 1 ml/min flow rate and detected at 266 nm by UV detection. The method was linear over the range of 4.0-90 μg.ml À1 with a recovery percentage of 99.81 ± 0.69. The acidic degradation behavior of GFX along with the kinetic investigation was evaluated as recommended by ICH-stress conditions. The separation of the degradation product was performed in good elution time (less than 8 min), and the suggested technique has a good reproducibility (R.S.D. less than 1.0%) and provides an excellent resolution (R s = 4.5) between GFX and its degradation product. Concerning the second drug, GTF, simple, extremely sensitive, and accurate spectrofluorimetric and spectrophotometric techniques were adopted for the determination of the drug in its pharmaceutical preparations. The suggested approaches utilize the concept of complex formation with eosin Y in an aqueous buffered solution. Regarding the spectrophotometric method (method I), the binary complex has a maximum absorption at 544 nm, while for spectrofluorimetric determination (method II) the formed complex was recorded at λ em 491 nm after excitation at 286 nm. For both approaches, variables affecting the formation of the binary complexes were extensively investigated and optimized. The suggested techniques were shown to be rectilinear across the concentration range of 0.5-8 and 0.05-1 μg.ml À1 , respectively, with recovery percentages of 100.34 ± 0.85 and 99.90 ± 0.81 for method (I) and method (II), respectively. In compliance with ICH guidelines, the analytical performance of

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UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk, Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies

Cited by 7 publications

References 26 publications

Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector

Dispersive micro solid phase extraction of glibenclamide from plasma, urine, and wastewater using a magnetic molecularly imprinted polymer followed by its determination by a high-performance liquid chromatography-photodiode array detector

A ternary nucleotide–lanthanide coordination nanoprobe for ratiometric fluorescence detection of ciprofloxacin

Multiple sensitive eco‐friendly analytical approaches for the determination of two fourth‐generation fluoroquinolones: Application to stability study and content uniformity testing

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