UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles

Fathi, Parinaz; Roslend, Ayman; Mehta, Kritika; Moitra, Parikshit; Zhang, Kai; Pan, Dipanjan

doi:10.1039/d0nr08485a

Cited by 14 publications

(12 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was understood that the supramolecular assembly, discussed herein, can be better explained by single crystal structures. Although CB inclusion complexes were studied by single crystal geometries, [ 62 , 63 , 64 ] carbon dots are generally amorphous in nature, [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ] as observed in its powder X‐ray diffraction pattern, and do not crystallize. Hence, the formation of single crystals has not been attempted in this study.…”

Section: Resultsmentioning

confidence: 99%

Small Molecule NIR‐II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots

et al. 2022

Self Cite

View full text Add to dashboard Cite

Small molecular NIR‐II dyes are highly desirable for various biomedical applications. However, NIR‐II probes are still limited due to the complex synthetic processes and inadequate availability of fluorescent core. Herein, the design and synthesis of three small molecular NIR‐II dyes are reported. These dyes can be excited at 850–915 nm and emitted at 1280–1290 nm with a large stokes shift (≈375 nm). Experimental and computational results indicate a 2:1 preferable host–guest assembly between the cucurbit[8]uril (CB) and dye molecules. Interestingly, the dyes when self‐assembled in presence of CB leads to the formation of nanocubes (≈200 nm) and exhibits marked enhancement in fluorescence emission intensity (Switch‐On). However, the addition of red carbon dots (rCDots, ≈10 nm) quenches the fluorescence of these host–guest complexes (Switch‐Off) providing flexibility in the user‐defined tuning of photoluminescence. The turn‐ON complex found to have comparable quantum yield to the commercially available near‐infrared fluorophore, IR‐26. The aqueous dispersibility, cellular and blood compatibility, and NIR‐II bioimaging capability of the inclusion complexes is also explored. Thus, a switchable fluorescence behavior, driven by host–guest complexation and supramolecular self‐assembly, is demonstrated here for three new NIR‐II dyes.

show abstract

Section: Resultsmentioning

confidence: 99%

Small Molecule NIR‐II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, biliverdin nanoparticles have been employed as a photoacoustic contrast agent. 106 In a study, Fathi et al developed a biliverdin nano system for PAI of the lymph node. Excitation wavelengths of 680, 720, and 750 nm were used to visualize mice after 5, 10, 15, and 30 min of injection.…”

Section: Contrast Agents For Pai In Small Animalsmentioning

confidence: 99%

“…The body has negligible background absorbance in the near-infrared range, where biliverdin exhibits significant absorbance. Therefore, biliverdin nanoparticles have been employed as a photoacoustic contrast agent . In a study, Fathi et al developed a biliverdin nano system for PAI of the lymph node.…”

Section: Contrast Agents For Pai In Small Animalsmentioning

confidence: 99%

Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

Dhamija,

Mehata,

Setia

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

“…A commonality between all carbon nanomaterials is the presence of sp 2 hybridized carbons that result in delocalized π electrons. These π electrons are essentially the origin of the phenomenal chemical, photochemical, and electrical properties of carbon nanomaterials (Fathi et al, 2019; Fathi, Roslend, et al, 2021; Misra et al, 2018; Nguyen et al, 2021; Ostadhossein, Vulugundam, et al, 2018; Srivastava et al, 2021; Srivastava, Khan, et al, 2020; Vulugundam et al, 2016). The mechanism behind the fluorescence of carbon nanomaterials was also studied by directly imaging individual carbon nanoparticles with sub‐particle resolution by scanning tunneling microscopy (Nguyen et al, 2020).…”

Section: Characteristics Of Carbon Nanoparticlesmentioning

confidence: 99%

A narrative review on the role of carbon nanoparticles in oncology

Watt

Moitra

Sheffield

et al. 2022

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

The lymphatic system is the first site of metastasis for most tumors and is a common reason for the failure of cancer therapy. The lymphatic system's anatomical properties make it difficult to deliver chemotherapy agents at therapeutic concentrations while avoiding systemic toxicity. Carbon nanoparticles offer a promising alternative for identifying and transporting therapeutic molecules. The larger diameter of lymphatic vessels compared to the diameter of blood vessels, allows carbon nanoparticles to selectively enter the lymphatic system once administered subcutaneously. Carbon nanoparticles stain tumor‐draining lymph nodes black following intratumoral injection, making them useful in sentinel lymph node mapping. Drug‐loaded carbon nanoparticles allow higher concentrations of chemotherapeutics to accumulate in regional lymph nodes while decreasing plasma drug accumulation. The use of carbon nanoparticles for chemotherapy delivery has been associated with lower mortality, fewer histopathology changes in vital organs, and lower serum concentrations of hepatocellular enzymes. This review will focus on the ability of carbon nanoparticles to target the lymphatics as well as their current and potential applications in sentinel lymph node mapping and oncology treatment regimens. This article is categorized under: Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery

show abstract

UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles

Abstract: UV irradiation and metal chelation can be utilized alone or in combination to tailor the fluorescence behavior of biliverdin-based imaging probes at selected wavelengths.

Cited by 14 publications

References 58 publications

Small Molecule NIR‐II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots

Small Molecule NIR‐II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots

Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

A narrative review on the role of carbon nanoparticles in oncology

Contact Info

Product

Resources

About