UV–Vis, FTIR and DFT Studies of the Fluoroquinolone [Pyrido Pyrolo Quinoxaline (PPQ)] Tethered to Gold Nanoparticles as a Novel Anticancer

Ababneh, Riad; Smadi, Maha; Bensiradj, Nour El Houda; Al-Akhras, M. Ali; Al‐Hiari, Yusuf; Jum’h, Inshad; Abu-Dahab, Rana; Al‐Bataineh, Qais M.; Telfah, Ahmad

doi:10.1007/s10904-023-02596-x

J Inorg Organomet Polym

2023

DOI: 10.1007/s10904-023-02596-x

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UV–Vis, FTIR and DFT Studies of the Fluoroquinolone [Pyrido Pyrolo Quinoxaline (PPQ)] Tethered to Gold Nanoparticles as a Novel Anticancer

Riad Ababneh

Maha Smadi

Nour El Houda Bensiradj

et al.

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2024

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Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

Peter,

Aderibigbe

2024

CTMC

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Background:: The concept of utilizing drug repurposing/repositioning in the development of hybrid molecules is an important strategy in drug discovery. Fluoroquinolones, a class of antibiotics, have been reported to exhibit anticancer activities. Although anticancer drug development is achieving some positive outcomes, there is still a need to develop new and effective anticancer drugs. Some limitations associated with most of the available anticancer drugs are drug resistance and toxicity, poor bio-distribution, poor solubility, and lack of specificity, which hamper their therapeutic outcomes. Objectives:: Fluoroquinolones, a known class of antibiotics, have been explored by hybridizing them with other pharmacophores and evaluating their anticancer activity in silico and in vitro. Hence, this review provides an update on new anticancer drugs development containing fluoroquinolones moiety, Ciprofloxacin and Norfloxacin between 2020 and 2023, their structural relationship activity, and the future strategies to develop potent chemotherapeutic agents. Methods:: Fluoroquinolones were mostly hybridized via the N-4 of the piperazine ring on position C-7 with known pharmacophores characterized, followed by biological studies to evaluate their anticancer activity. Results:: The hybrid molecules displayed promising and interesting anticancer activities. Factors such as the nature of the linker, the presence of electron-withdrawing groups, nature, and position of the substituents influenced the anticancer activity of the synthesized compounds Conclusion:: The hybrids were selective towards some cancer cells. However, further in vivo studies are needed to fully understand their mode of action

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Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

Peter,

Aderibigbe

2024

CTMC

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UV–Vis, FTIR and DFT Studies of the Fluoroquinolone [Pyrido Pyrolo Quinoxaline (PPQ)] Tethered to Gold Nanoparticles as a Novel Anticancer

Cited by 1 publication

References 39 publications

Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents

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