UV–Vis quantification of hydroxyl radical concentration and dose using principal component analysis

Lankone, Ronald S.; Deline, Alyssa R.; Barclay, Michael; Fairbrother, D. Howard

doi:10.1016/j.talanta.2020.121148

Cited by 52 publications

(14 citation statements)

References 43 publications

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“…Determination of • OH Radical Dose. The total dose of • OH generated by the photodegradation of H 2 O 2 as well as the equivalent environmental exposure time in natural surface waters (Table S1) were determined using methods described by Lankone et al 34 Briefly, the steady-state • OH concentration in solution generated during the photolysis of H 2 O 2 was determined via monitoring the rate of salicylic acid (i.e., a probe molecule) decomposition from an initial concentration of 0.07 mM. With this methodology, the steady-state concentration of • OH with CDs present in solution could be determined with a standard error of less than 10%.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Photochemical Transformations of Carbon Dots in Aqueous Environments

Frank

Sigmon

Deline

et al. 2020

Environ. Sci. Technol.

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The unique physicochemical and luminescent properties of carbon dots (CDs) have motivated research efforts toward their incorporation into commercial products. Increased use of CDs will inevitably lead to their release into the environment where their fate and persistence will be influenced by photochemical transformations, the nature of which is poorly understood. This knowledge gap motivated the present investigation of the effects of direct and indirect photolysis on citric and malic acid−based CDs. Our results indicate that natural sunlight will rapidly and non-destructively photobleach CDs into optically inactive carbon nanoparticles. We demonstrate that after photobleaching, • OH exposure degrades CDs in a two-step process that will span several decades in natural waters. The first step, occurring over several years of • OH exposure, involves depolymerization of the CD structure, characterized by volatilization of over 60% of nascent carbon atoms and the oxidation of nitrogen atoms into nitro groups. This is followed by a slower oxidation of residual carbon atoms first into carboxylic acids and then volatile carbon species, while nitrogen atoms are oxidized into nitrate ions. Considered alongside related CD studies, our findings suggest that the environmental behavior of CDs will be strongly influenced by the molecular precursors used in their synthesis.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Photochemical Transformations of Carbon Dots in Aqueous Environments

Frank

Sigmon

Deline

et al. 2020

Environ. Sci. Technol.

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“…† This reaction can be observed using UV-Vis spectroscopy. 75 Fig. 5 shows the UV-Vis spectra for the photocatalytic reaction of salicylic acid in the presence of TiO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…69,70 Salicylic acid can be used as a probe molecule to experimentally identify the presence of hydroxyl radical. [71][72][73][74][75] The model reaction between salicylic acid and OHc radical forms two primary products, designated as 2,3-dihydroxybenzoic acid and 2,5-dihydroxybenzoic acid, shown in Fig. S7.…”

Section: Effect Of the Mass And Ph On The By-product Formationmentioning

confidence: 99%

Photocatalytic degradation of ibuprofen using titanium oxide: insights into the mechanism and preferential attack of radicals

et al. 2021

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“…In the past few decades, several analytical methods, including electron spin resonance (ESR) spectroscopy 22 , 23 , ultraviolet–visible (UV–vis) chromatography 24 , and fluorescence (FL) imaging 25 – 29 , have been devoted for the detection of •OH. Among them, FL imaging of •OH has attracted tremendous attention due to the advantage of high sensitivity, easy operation, rapid acquirement, and minimum invasiveness 30 – 32 .…”

Section: Introductionmentioning

confidence: 99%

Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

Ishigaki

Zeng

et al. 2021

Nat Commun

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Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL780/FL1113), but a small PA ratio between 755 and 905 nm (PA755/PA905). Oxidation of 1-Br-Et by •OH decreases the FL780/FL1113 while concurrently increasing the PA755/PA905, allowing the reliable monitoring of •OH production in tumors undergoing erastin-induced ferroptosis or radiotherapy.

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UV–Vis quantification of hydroxyl radical concentration and dose using principal component analysis

Cited by 52 publications

References 43 publications

Photochemical Transformations of Carbon Dots in Aqueous Environments

Photochemical Transformations of Carbon Dots in Aqueous Environments

Photocatalytic degradation of ibuprofen using titanium oxide: insights into the mechanism and preferential attack of radicals

Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

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