UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

Prasedya, Eka Sunarwidhi; Syafitri, Sundari Maulinda; Geraldine, Brigitta A. F. D.; Hamdin, Candra Dwipayana; Frediansyah, Andri; Miyake, Masakazu; Kobayashi, Daisuke; Hazama, Akihiro; Sunarpi, Haji

doi:10.3390/biomedicines7040077

Cited by 29 publications

(25 citation statements)

References 30 publications

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“…The antioxidant and photoprotective effects of these group of compounds obtained from seaweeds in general, and from Fucus species in particular, were recently reviewed [ 10 , 37 , 44 ], supporting the results here obtained. Effectively, systematic exposure of human skin to UV radiation promotes severe skin injuries like sunburns, aging, inflammation, and photo-carcinogenesis [ 52 ]. As many other marine organisms, seaweeds are highly exposed to UV radiation and, as a consequence, they have developed a mechanism of defence to counteract or minimize radiation damage through the biosynthesis of photoprotective substances like pigments, mycosporine-like amino acids, sulfated polysaccharides, and phenolic compounds [ 10 , 19 , 44 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Effectively, systematic exposure of human skin to UV radiation promotes severe skin injuries like sunburns, aging, inflammation, and photo-carcinogenesis [ 52 ]. As many other marine organisms, seaweeds are highly exposed to UV radiation and, as a consequence, they have developed a mechanism of defence to counteract or minimize radiation damage through the biosynthesis of photoprotective substances like pigments, mycosporine-like amino acids, sulfated polysaccharides, and phenolic compounds [ 10 , 19 , 44 , 52 , 53 ]. Among this last group, phlorotannins are known for their strong antioxidant and photoprotective properties.…”

Section: Discussionmentioning

confidence: 99%

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Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications

et al. 2020

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Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 µg/mL) and by UVB (IC50 of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications

et al. 2020

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“…These were normal healthy controls with no UV treatment (NC), normal healthy controls with UV treatment (VC), and UV irradiation with 0.1% SC treatment (SCE). The choice of concentration for animal experiments is based on the previous work which shows that 0.1% concentration of SCE shows significant protective activities against UV radiation [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…In our previous work, Sargassum cristaefolium ethanol (SCE) extract showed potential photoprotective activity against UV-A radiation [ 14 ]. However, the underlying mechanisms of SCE UV photoprotective activity have not been studied and remain largely unresolved.…”

Section: Introductionmentioning

confidence: 99%

Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice

et al. 2020

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Ultraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unclear. The purpose of this study is to investigate the potential mechanism of S. cristaefolium’s photoprotective activity against UV radiation. Phytochemical analyses revealed valuable bioactive compounds in SCE, such as fucoxanthin which is widely known as an anti-inflammatory carotenoid. Treatment with SCE before UV-A radiation show reduced levels of wrinkles and desquamation. Interestingly, SCE treatment induces the skin healing process after UV radiation. SCE effectively inhibited proinflammatory TNF-α and IL-6 expression while increasing IL-10 production in the BALB/c mice skin. Current results suggest that SCE potentially protects the skin by attenuation of inflammatory cytokines. In addition, SCE demonstrates promising antibacterial activity (MIC = 1.302 µg/mL) against Staphylococcus aureus. Overall, SCE could be a source of an effective anti-inflammatory agent protecting against UV irradiation-induced skin damages.

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“…Skin photoprotection is one of the golden standards primarily for the prevention of ROS-induced damage. The application of topical antioxidant sources, especially photoprotective agents containing UVB and UVA filters, effectively protects the skin from sunburn, photoageing, DNA mutations and carcinogenesis [2,7,8,27,37,40]. In the present study, through the analysis and morphometric techniques of measuring of the structural parts of the skin of mice a clear qualitative and quantitative difference is intended to be shown in appearance and structure of unprotected and photo protected mouse skin exposed to high dosages of UVA radiation.…”

Section: Introductionmentioning

confidence: 95%

The structural characteristics of photoageing in mice caused by the effects of ultraviolet A radiation

Savic¹,

Smiljic²,

Leštarević³

et al. 2020

Folia Morphol

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Background: Due to its deep penetration into the dermis, ultraviolet A (UVA) radiation is considered a primary factor in skin photoageing. The aim of this study is to use a qualitative and quantitative analysis to determine the structural parameters of skin photoageing in mice exposed to UVA radiation, with or without the application of a photoprotective cream. Materials and methods: The experiment consisted of the radiation of female BALBc mice in a solarium by UVA rays, up to total dosages of 7800 J/cm 2 and 12500 J/cm 2 . A total of 78 animals were divided into four experimental and two control groups. All animals were shaved and the animals in two experimental groups were treated with a photoprotective cream half an hour before exposure. The samples of the treated skin were stained with haematoxylin-eosin and Van-Gieson staining methods. All measurements, except for the presence of dyskeratosis, were taken using ImageJ 150i software. Results: In the study, the signs of skin photoageing were more evident in untreated groups of animals. Dyskeratosis was more frequent in both of the untreated groups of animals (p = 0.004 and p = 0.003). The lowest values of epidermal thickness (13.8 ± 2.6 μm and 12.7 ± 2.3 μm) were present in both of the untreated groups of animals (p < 0.001 and p < 0.001). The highest values of stratum corneum thickness (34.3 ± 8.5 μm) were observed in the untreated, shorter radiated group of animals (p < 0.001) which was irradiated for the shortest period of time. Beside the control groups, the highest length of dermo-epidermal junction was recorded in the group of treated, longer radiated animals (1467.6 ± 94.6 μm; p = 0.373). The lowest values of dermal thickness (115.9 ± 10.5 μm and 134.8 ± 21.8 μm) and volumetric density of the collagen fibres (31.92 ± 3.19% and 29.40 ± 4.54%) were present in both untreated groups of animals (p < 0.001, p < 0.001, p = 0.035). Conclusions: Skin photoageing was most pronounced in the groups of animals irradiated without the application of photoprotective cream.

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UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

Cited by 29 publications

References 30 publications

Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications

Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications

Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice

The structural characteristics of photoageing in mice caused by the effects of ultraviolet A radiation

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