UVA1 irradiation attenuates collagen production via Ficz/AhR/MAPK signaling activation in scleroderma

Shi, Yaqian; Xiao, Yangfan; Yu, Jiangfan; Liu, Jiani; Liu, Licong; Ding, Yan; Qiu, Xianyang; Zhan, Yi; Tang, Rui; Zeng, Zhuotong; Xiao, Rong

doi:10.1016/j.intimp.2023.109764

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…Furthermore, they confirmed an antifibrotic effect of AhR agonism in SSc model in mice [42]. More recently, this same group evidenced that UVA1 irradiation, which is a phototherapy procedure used in local SSc, reduced fibrosis via an AhR mechanism [43]. Interestingly, KYNA is also an AhR agonist [44] with known antifibrotic properties [13].…”

Section: Discussionmentioning

confidence: 78%

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

Turska-Kozłowska,

Pedraz-Petrozzi,

Paluszkiewicz

et al. 2024

IJMS

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Systemic sclerosis (SSc), a predominantly female-affected systemic autoimmune disease, requires tailored treatment strategies contingent on organ involvement and symptom severity. Given SSc’s inflammatory nature, the involvement of the kynurenine pathway (KP) in its pathophysiology is underexplored. Our study aimed to investigate sex-related differences in KP activation among SSc patients and assess the impact of angiotensin-converting enzyme (ACE) inhibitors and estimated glomerular filtration rate (eGFR) on KP metabolite concentrations. We enrolled 48 SSc patients and 53 healthy controls, quantifying KP metabolites (tryptophan (TRP), kynurenine (KYN), and kynurenic acid (KYNA)) in serum via high-performance liquid chromatography. Separate multivariate analyses of covariance (MANCOVAs) for women and men were performed to ascertain mean differences between patients and healthy controls while correcting for age. For our secondary objective, we conducted a MANCOVA to explore disparities in ACE inhibitor users and non-users among patients, with BMI correction. Our findings revealed decreased TRP concentrations but increased KYNA/TRP ratio and KYN/TRP ratio in both male and female SSc patients compared to their respective controls. Unlike women, SSc males exhibited higher KYN concentrations and decreased KYNA/KYN ratio relative to their controls. Additionally, SSc patients using ACE inhibitors had higher serum KYNA levels than non-users. Notably, we established a significant correlation between eGFR and KYNA in SSc patients. These results indicate differential KP activation in male and female SSc patients, with males demonstrating heightened KP activation. While ACE inhibitors may influence the KP in SSc patients, further research is necessary to comprehensively understand their impact on symptoms and prognosis in the context of these KP alterations.

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Section: Discussionmentioning

confidence: 78%

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

Turska-Kozłowska,

Pedraz-Petrozzi,

Paluszkiewicz

et al. 2024

IJMS

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“…After 4 weeks of treatment, the skin redness a* value was further significantly reduced by 9.84% (T0d: 25.31 ± 6.47, T7d: 23.67 ± 6.35, T28d: 22.82 ± 6.99, with p < 0.001 respectively). The sebum content in the forehead area, as measured by Sebumeter, was significantly reduced by 13 The results are shown in Figure 1, 2, 3, 4, 5, and 6. One average case with VISIA pictures is shown in Table 1.…”

Section: Treatment Efficacymentioning

confidence: 85%

“…12 Additionally, prolonged exposure to UVR, particularly UVA1, can damage structural proteins like collagen and elastin, thereby compromising the skin's barrier function. 13 The sunscreen's ability to shield the skin from such harmful UVR is crucial in preventing this damage and sustaining the integrity of the skin barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported the detrimental effects of UVB radiation, such as delayed alterations and epidermal proliferative responses, on the skin barrier 12 . Additionally, prolonged exposure to UVR, particularly UVA1, can damage structural proteins like collagen and elastin, thereby compromising the skin's barrier function 13 . The sunscreen's ability to shield the skin from such harmful UVR is crucial in preventing this damage and sustaining the integrity of the skin barrier.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the efficacy of a sunscreen containing ultra‐long UVA1 and other UVR broad‐spectrum filters on skin barrier protection and melanin content reduction in Chinese adults: A single‐center study

Zhang,

Tao,

Zhang

et al. 2024

Health Science Reports

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Background and AimsThe protection for ultra‐long UVA1 is lacked in the market, posing potential damage from ultra‐long UVA1 irradiation. The study aims to evaluate the efficacy of a sunscreen containing multiple components, especially Mexoryl® 400 for improving skin barrier function and reducing melanin content.MethodsThis single‐center study included adults with sensitive and normal skin in China in November 2022. Participants received the test sunscreen for 4 weeks. Melanin and hemoglobin content, sebum secretion skin hydration, and trans‐epidermal water loss were evaluated at T0d, T7d, and T28d. The self‐assessment was done at T15min, T7d, and T28d.ResultsSixty participants were included, including 30 self‐claimed sensitive skin in the sunscreen group. The sunscreen demonstrated significant improvements in skin parameters. Skin redness reduced by 9.84% at T28d, sebum content in the forehead area decreased by 22.70% at T28d, and skin stratum corneum hydration increased by 38.44% at T28d, p < 0.001 respectively. Most notably, skin melanin content significantly reduced by 13.49% after 4 weeks' usage (p < 0.001). No adverse reactions were reported in either group.ConclusionsThe study sunscreen improved the skin condition by decreasing the melanin content, regulating skin barrier function, and achieving a balance of skin hydration and sebum secretion.

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MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway

Tang,

Yu,

Tang

et al. 2024

iScience

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UVA1 irradiation attenuates collagen production via Ficz/AhR/MAPK signaling activation in scleroderma

Cited by 3 publications

References 48 publications

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

Evaluation of the efficacy of a sunscreen containing ultra‐long UVA1 and other UVR broad‐spectrum filters on skin barrier protection and melanin content reduction in Chinese adults: A single‐center study

MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway

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