Uvaol Exerts Anti-Proliferative and Pro-Apoptotic Effects on Human Hepatocarcinoma Cells by Modulating AKT/PI3K Signaling Pathway

Gc, Bonel-Pérez; Pérez‐Jiménez, Amalia; Gris-Cárdenas, Isabel; Am, Parra-Pérez; Lupiáñez, José A.; Reyes‐Zurita, Fernando J.; Siles, Eva; Csuk, René; Peragón, Juan; Rufino‐Palomares, Eva E.

doi:10.20944/preprints202008.0112.v1

Cited by 1 publication

(2 citation statements)

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“…Callus tissue from the stems of A. arguta (Actinidiaceae) produced three ursane-type triterpenes including ursolaldehyde 41, α-amyrin 42, and uvaol 43 [26]. Of them, compound 43 showed anti-inflammatory, anticancer, and wound healing activities [27][28][29]. Antiinflammatory properties of 43 on DSS-induced colitis and LPS-stimulated macrophages have been explored detailly and completely.…”

Section: Ursane Triterpenoidsmentioning

confidence: 99%

“…arguta [ 34 ] Leaves 39 (2 α ,3 β )-2,3,23-Trihydroxyurs-13(18)-en-28-oic acid A. chinensis Planch [ 52 ] Roots 40 Fupenzic acid A . chinensis [ 25 ] Root bark Antiviral (in vitro) [ 25 ] 41 Nrsolaldehyde A. arguta [ 26 ] Stems 42 α -Amyrin A. arguta [ 26 ] Stems 43 Uvaol A. arguta [ 26 ] Stems Anti-inflammatory (in vivo) [ 27 ] Anticancer (in vitro) [ 28 ] Wound healing (in vivo) [ 29 ] 44 Pseudotaraxasterol A. chinensis Planch [ 19 ] Roots 45 2 α ,3 α ,24-Trihydroxyurs-11-en-13,28-olide A. polygama [ 23 ] Fruit galls 46 2 α ,3 β -Dihydroxyurs-12-en-28,30-olide A. chinensis [ 30 ] Roots …”

Section: Chemical Constituentsmentioning

confidence: 99%

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Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

Liu

et al. 2021

Nat. Prod. Bioprospect.

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Kiwi, a fruit from plants of the genus Actinidia, is one of the famous fruits with thousand years of edible history. In the past twenty years, a great deal of research has been done on the chemical constituents of the Actinidia species. A large number of secondary metabolites including triterpenoids, flavonoids, phenols, etc. have been identified from differents parts of Actinidia plants, which exhibited significant in vitro and in vivo pharmacological activities including anticancer, anti-inflammatory, neuroprotective, anti-oxidative, anti-bacterial, and anti-diabetic activities. In order to fully understand the chemical components and biological activities of Actinidia plants, and to improve their further research, development and utilization, this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020, classifies the types of constituents, reports on the pharmacological activities of relative compounds and medicinal potentials.

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