UVB-induced bullous pemphigoid in a patient with psoriasis

Ceryn, Justyna; Skibińska, Małgorzata; Barasińska, Paulina; Noweta, Marcin; Lesiak, Aleksandra

doi:10.5114/ada.2020.97725

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…Opisywano również przypadki pacjentów z łuszczycą, u których zmiany o typie pemfigoidu, zostały wywołane podczas fototerapii UVB [14]. Również tutaj mechanizm nie jest wyjaśniony.…”

Section: Discussionunclassified

“…Również tutaj mechanizm nie jest wyjaśniony. Przypuszcza się, że promieniowanie UV może powodować uszkodzenia w obrębie błony podstawnej z następczą produkcją przeciwciał przeciwko jej składnikom [14,15].…”

Section: Discussionunclassified

“…There have also been reports of patients with psoriasis in whom pemphigoid lesions were induced during UVB phototherapy [14]. Also in these cases the mechanism is not clear.…”

Section: Opisy Przypadkówmentioning

confidence: 99%

“…Also in these cases the mechanism is not clear. It is believed that UV radiation can cause damage to the basal membrane with subsequent production of antibodies against its components [14,15].…”

Section: Opisy Przypadkówmentioning

confidence: 99%

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Pemphigoid nodularis – diagnostic challenges

Grzeszczuk¹,

Woźniacka²,

Żebrowska³

et al. 2022

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Introduction: Bullous pemphigoid is an autoimmune bullous disease that occurs most often in old age. The nodular form of pemphigoid may mimic other dermatoses, but also coexist with them, which causes diagnostic and therapeutic difficulties. Case reports: We present cases of two women (81-year-old and 67-year--old) with a several year history of polymorphic lesions who were initially diagnosed as nodular prurigo. At that time both patients were treated with phototherapy with good tolerance and improvement. During the next courses of UVB-NB irradiation, the condition of their skin deteriorated significantly. Direct immunofluorescence and indirect immunofluorescence studies identified pemphigoid. The initiated pharmacological treatment with methotrexate and systemic glucocorticosteroids resulted in a significant clinical improvement. Conclusions: Presented cases draw attention to the atypical clinical presentation and the impact of UVB-NB phototherapy on the appearance of the first symptoms of pemphigoid.

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Section: Discussionunclassified

“…There have also been reports of patients with psoriasis in whom pemphigoid lesions were induced during UVB phototherapy [14]. Also in these cases the mechanism is not clear.…”

Section: Opisy Przypadkówmentioning

confidence: 99%

Section: Opisy Przypadkówmentioning

confidence: 99%

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Pemphigoid nodularis – diagnostic challenges

Grzeszczuk¹,

Woźniacka²,

Żebrowska³

et al. 2022

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“…Immune-mediated skin diseases like pemphigus have been associated with other autoimmune disorders and have the potential to induce occurrence of another immune-mediated skin disease [ 1 ]. Many of the treatment modalities including but not limited to ultraviolet B (UVB) therapy and steroids are linked to the development of immune-mediated skin diseases as well [ 2 ]. Our case report elaborates on the risk factors and the mechanisms through which they predispose to the evolution of pemphigus vulgaris with special emphasis on the contribution of another coexisting immune-mediated disorder like psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Immunobullous Transformation of Protracted Psoriasis: A Diagnostic Dilemma

Ramachandran¹,

Shridhar²,

Vaidya³

et al. 2023

Cureus

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Pemphigus vulgaris is a rare autoimmune disorder, characterised by the development of blistering lesions in the skin and mucosal surfaces throughout the body. It is often misdiagnosed or missed completely in many patients, prolonging their suffering for many years, as it has the ability to mimic an array of other skin diseases.Many studies have concluded that there is a strong association between pemphigus vulgaris and psoriasis, though the exact mechanism is not clearly understood. We present the case of a 77-year-old gentleman on long-term treatment for psoriasis with ultraviolet B phototherapy, steroids, and many other topical treatments who eventually went on to develop pemphigus vulgaris.

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Development of bullous systemic lupus erythematosus in patient treated with NB‐UVB: A case report and comprehensive review of the literature

Behrangi,

Jafarzadeh,

Dehghani

et al. 2024

Clinical Case Reports

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Key Clinical MessageThe use of phototherapy is highly effective in treating various skin diseases. In this study, the aim is to present vesicular and blister lesions in patients treated with UVB for psoriasis. It is advisable to consider the possibility of BSLE in cases of vesiculobullous lesions following phototherapy, along with other potential diagnoses.AbstractBullous systemic lupus erythematosus (BSLE) is a rare form of cutaneous lupus erythematosus that presents as vesicles and blisters on various parts of the body. The pathological appearance of these lesions often shows subepidermal vesicles with deposits of IgG, IgM, IgA, and complement C3 in granular or linear forms under direct immunofluorescence (DIF) examination. Clinical studies demonstrate the effectiveness of phototherapy in treating various skin conditions. While several studies suggest a correlation between phototherapy and the development of vesiculobullous lesions, most of these reports are related to bullous pemphigoid, with limited research on the occurrence of BSLE following phototherapy. In this case report, vesicular and blistering lesions in a 70‐year‐old man undergoing UVB treatment for psoriasis are described. Pathological examination confirmed the diagnosis of bullous systemic lupus erythematosus, and the patient experienced significant improvement after treatment with dapsone tablets. A literature review was conducted on the development of vesiculobullous lesions after phototherapy, comparing different approaches presented in previous studies. Our conclusion highlights the importance of considering BSLE as a possible diagnosis in cases of vesiculobullous lesions post‐phototherapy, alongside other potential conditions.

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UVB-induced bullous pemphigoid in a patient with psoriasis

Cited by 7 publications

References 9 publications

Pemphigoid nodularis – diagnostic challenges

Pemphigoid nodularis – diagnostic challenges

Immunobullous Transformation of Protracted Psoriasis: A Diagnostic Dilemma

Development of bullous systemic lupus erythematosus in patient treated with NB‐UVB: A case report and comprehensive review of the literature

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