2023
DOI: 10.1101/2023.02.03.526940
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UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during crypticLeishmania donovaniinfection

Abstract: Many parasites of significant public health importance assume skin residency without causing overt pathlogy. How immune and stromal cells respond to such cryptic infections and how exposure to UVB alters such responses in poorly understood. We combined scRNA-seq, spatial transcriptomics and inferential network analysis to address these questions in a model of cryptic skin infection by Leishmania donovani. In infected C57BL/6 mice, p-selectin and CXCL12 interactions dominate intercellular communication between … Show more

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