Uveal melanoma in an 18‐year‐old African black man

Gambrelle, J.; Dayan, Guila; Baggetto, Loïc; Devouassoux‐Shisheboran, Mojgan; Salle, Monique; Labialle, Stéphane; Gayet, Landry; Barakat, Stéphane; Kodjikian, Laurent; Grange, Jean‐Daniel

doi:10.1111/j.1600-0420.2005.00386.x

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Histopathologic studies have reported that the clinical and genetic course of nonwhite patients with UM may be different than in white patients, with Asian Indian individuals presenting younger, Mexican-Mestizo patients showing a previously unreported polymorphism, and Hispanic patients presenting with unique symptoms and broader-based tumors . Various case reports have shown that UM occurs in all races …”

Section: Introductionmentioning

confidence: 99%

“…2 Various case reports have shown that UM occurs in all races. 2,[16][17][18][19][20] Research into the association of SES with UM incidence and treatment has been inconclusive. Zinkhan et al 21 reported a decreased incidence in higher SES populations, suggesting possible occupational risk, while Shildkrot et al 22 found the opposite, even when controlling for race; 2 other studies found no association between SES and UM incidence.…”

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confidence: 99%

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Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

et al. 2020

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Identifying disparities in uveal melanoma (UM) treatment patterns and survival across racial, ethnic, and socioeconomic (SES) groups reveals possible inequities in ophthalmologic health care.OBJECTIVE To examine the association of race, ethnicity, and SES with UM treatment and survival. DESIGN, SETTING, AND PARTICIPANTSA retrospective cohort analysis of 28% of the US population using the Surveillance, Epidemiology, and End Results (SEER) 18 registries from January 1, 2004, to December 31, 2014, was conducted. Data analysis was performed from April to July 2018. SEER identified 4475 individuals using International Classification of Diseases for Oncology, Third Edition site and morphology codes.EXPOSURES Race, ethnicity, and SES estimated by tertile using Yost Index composite scores.MAIN OUTCOMES AND MEASURES Treatment odds ratios (ORs), 1-year and 5-year survival estimates, mortality hazard ratios (HRs), and Kaplan-Meier survival curves. Hypothesis was formulated before data collection.RESULTS Multivariate analyses of 4475 individuals (2315 [51.7%] men; non-Hispanic white, 4130 [92.3%]; nonwhite, 345 [7.7%]) showed that patients who were nonwhite (OR, 1.45; 95% CI, 1.12-1.88) and socioeconomically disadvantaged (lower SES: OR, 2.21; 95% CI, 1.82-2.68; middle SES: OR, 1.86; 95% CI, 1.56-2.21) were more likely to receive primary enucleation. No interactions were observed between race/ethnicity, SES, and stage at diagnosis. From 2004 to 2014, rates of primary enucleation decreased across all racial/ethnic and SES groups, but disparities persisted. Socioeconomically disadvantaged patients had lower 5-year all-cause survival rates (lower SES: 69.2%; middle SES: 68.1%; and upper SES: 73.8%), although disease-specific survival did not vary significantly by racial/ethnic or SES strata. Mortality risk was associated with older age at diagnosis

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

et al. 2020

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“…The annual incidence was shown to be 0.2 per million in an African-American population versus 6.9 per million in a Caucasian population in the study by Margo and McLean [14] . A number of reported cases associate uveal melanomas in African-American patients with oculodermal melanocytosis [15] or melanocytoma [16,17] , though there are other reports without the association [18][19][20] . Our patient described herself as African-American, though on further questioning, she reported mixed ancestry with Caucasian ancestors on the mother's side and native Indian ancestors on the father's side.…”

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confidence: 99%

Diagnostic and Management Challenges of Ciliary Body Tumor in an African-American Patient

Salvi

Singh

2015

Ocul Oncol Pathol

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side and native Indian ancestors on the father's side. Information on true ethnicity should be specifically asked for as it alters the incidence rate. Biopsy provides the only option for a correct diagnosis and for developing a management plan. Fine-needle aspiration biopsy can be diagnostic, though an open flap biopsy is superior as it provides information on tissue architecture and the possibility of immunohistochemistry. Also, with plaque brachytherapy treatment, special care needs to be taken not to disturb the biopsy site to reduce the risk of seeding, and an innovative approach may need to be taken to ensure adequate radiation coverage of these anterior tumors.

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Proton Therapy for Uveal Melanoma in 43 Juvenile Patients

et al. 2014

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After PBRT, metastatic and survival rates are significantly better for juvenile than for adult patients with UM. Clinically, juvenile and adult eyes react similarly to PBRT, with patients having a comparable eye retention probability and maintaining a useful level of vision in most cases. This is the largest case-control study of proton therapy in juvenile eyes to date and further validates PBRT as an appropriate conservative treatment for UM in patients younger than 21 years.

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Uveal melanoma in an 18‐year‐old African black man

Cited by 5 publications

References 2 publications

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

Diagnostic and Management Challenges of Ciliary Body Tumor in an African-American Patient

Proton Therapy for Uveal Melanoma in 43 Juvenile Patients

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