Uveal Melanoma Survival in Sweden from 1960 to 1998

Bergman, Louise; Seregard, Stefan; Nilsson, Bo; Lundell, G; Ringborg, Ulrik; Ragnarsson-Olding, Boel

doi:10.1167/iovs.03-0081

Cited by 122 publications

(140 citation statements)

References 32 publications

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“…The majority of cutaneous melanomas occur in areas exposed to sun radiation, whereas the majority of uveal melanomas occur in the posterior segment of the eye, which is not exposed to significant sun radiation. Chromosomal assessment and molecular biological and epidemiological studies demonstrate that cutaneous melanomas differ from uveal melanomas (29)(30)(31)(32)(33)(34), whereas conjunctival melanomas appear to have more similarities to cutaneous than uveal melanomas (32,34). The primary underlying biological differences between uveal and cutaneous melanomas may be associated with various gene mutations and differing microenvironments.…”

Section: Discussionmentioning

confidence: 99%

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

Xue

Chen

et al. 2016

Oncology Letters

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Abstract. Uveal melanoma is the most common intraocular malignant tumor in adults. Chrysin is a flavonoid present in honey, propolis, various plants and herbs. In the present study, the cytotoxic effects of chrysin were investigated on human uveal melanoma cell lines (M17 and SP6.5) and associated signaling pathways, and a comparison to the effects on normal ocular cells [scleral fibroblasts and retinal pigment epithelial (RPE) cells] was performed. The effects of chrysin on cell viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell apoptosis was determined by using terminal deoxynucleotidyl transferase mediated dUTP nick end-labeling assay. Mitochondrial permeability was determined by JC-1 fluorescein analysis. Cytosol cytochrome c levels, and the activities of caspase-3, -8 and -9 were measured by enzyme-linked immunosorbent assay or colorimetric assay. Chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC 50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively. Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of scleral fibroblasts and RPE cells. Chrysin increased mitochondrial permeability, the levels of cytosol cytochrome c, and caspase-9 and -3 activities, but not capase-8 activity in uveal melanoma cells. The results of the present study indicate that chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway and suggest that chrysin may be a promising agent in the treatment of uveal melanoma.

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Section: Discussionmentioning

confidence: 99%

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

Xue

Chen

et al. 2016

Oncology Letters

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“…Despite successful treatment of the primary tumour approximately 50% of patients develop metastatic disease, which is usually unresponsive to chemotherapy and invariably fatal (Bergman et al, 2003). Tumours most commonly arise in the choroids with less than 10% developing in the iris and ciliary body.…”

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confidence: 99%

Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3

et al. 2005

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Defining regions of genomic imbalance can identify genes involved in tumour development. Conventional cytogenetics has identified several nonrandom copy number alterations (CNA) in uveal melanomas (UVM), which include monosomy 3, chromosome 6 abnormalities and gain of 8q. To gain further insight into the CNAs and define the regions involved more precisely we analysed 18 primary UVMs using 1 Mb BAC microarray comparative genomic hybridisation (CGH). Our analysis showed that the most common genomic imbalances were 8q gain (78%), 6p gain (67%) and monosomy 3 (56%). Two distinct CGH profiles could be delineated on the basis of the chromosome 3 status. The most common genetic changes in monosomy 3 tumours, in our study, were gain of 8q11.21 -q24.3, 6p25.1 -p21.2, 21q21.2 -q21.3 and 21q22.13 -q22.3 and loss of 1p36. 33 -p34.3, 1p31.1 -p21.2, 6q16.2 -q25.3 and 8p23.3 -p11.23. In contrast, disomy 3 tumours showed recurrent gains of only 6p25.3 -p22.3 and 8q23.2 -q24.3. Our approach allowed definition of the smallest overlapping regions of imbalance, which may be important in the development of UVM.

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“…La supervivencia relacionada con melanoma uveal en población americana es del 80%, permaneciendo estable durante los últimos 30 años 2 . En países del norte de Europa, como Inglaterra o Suecia, el índice de supervivencia es menor, alrededor el 70% 23,24 . Mientras que en los estudios de población israelí y española los valores mejoran hasta un 90% 19,20 .…”

Section: Discussionunclassified

Melanoma uveal: características clínicas, tratamiento y supervivencia en una serie de 500 pacientes

Vicente

Saornil

García-Álvarez

et al. 2013

Archivos de la Sociedad Española de Oftalmología

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Uveal Melanoma Survival in Sweden from 1960 to 1998

Abstract: This study, covering more than 95% of the uveal melanoma cases in the Swedish population revealed an improvement in relative survival rates for patients with uveal melanoma over time and a significant excess mortality up to 5.5 years after diagnosis.

Cited by 122 publications

References 32 publications

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3

Melanoma uveal: características clínicas, tratamiento y supervivencia en una serie de 500 pacientes

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