Uveitic Foveal Atrophy

Forooghian, Farzin

doi:10.1001/archophthalmol.2008.564

Cited by 34 publications

(13 citation statements)

References 35 publications

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“…2, 3). Inflammation generally causes a more diffuse microvascular leakage, though it may be patchy in nature, but is not limited to the area surrounding the foveal avascular zone or areas of nonperfusion (Forooghian et al, 2009) 28 .…”

Section: Fluorescein Angiographymentioning

confidence: 99%

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Cystoid Macular Edema in Uveitis

Smet¹,

Okada²

2010

Developments in Ophthalmology

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Macular edema is a major cause of morbidity in uveitis patients. Inflammatory mediators act on the integrity of the blood ocular barrier and on the function of the RPE pump. Chronicity leads to irreversible changes and is reported to cause up to 30% of permanent visual loss in uveitis patients. Assessing the presence and severity of edema with appropriate investigational techniques (Spectral domain OCT, and angiography) help to determine its reversibility and define a therapeutic strategy wherein intraocular steroids play a key role while RPE pump stimulators and surgery are restricted to more severe disease or the presence of tractional syndromes.

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Section: Fluorescein Angiographymentioning

confidence: 99%

“…Control of inflammation will often lead to resolution of the edema, provided the cause is mainly inflammatory and not due to macular ischemia or associated with macular atrophy (Forooghian et al, 2009) 28 . Here the therapeutic Fig.…”

Section: Anti-inflammatory Medicationmentioning

confidence: 99%

Cystoid Macular Edema in Uveitis

Smet¹,

Okada²

2010

Developments in Ophthalmology

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“…Forooghian et al specifically associated a history of CNV with posterior uveitis in one cross-sectional retrospective case series 19 .…”

Section: Discussionmentioning

confidence: 99%

Risk of Choroidal Neovascularization among the Uveitides

Baxter

Pistilli

Pujari

et al. 2013

American Journal of Ophthalmology

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Purpose To evaluate the risk, risk factors, and visual impact of choroidal neovascularization (CNV) in uveitis cases. Design Retrospective cohort study Methods Standardized medical record review at five tertiary centers. Results Among 15,137 uveitic eyes (8,868 patients), CNV was rare in the cases of anterior or intermediate uveitis. Among the 4,041 eyes (2,307 patients) with posterior or panuveitis, 81 (2.0%) presented with CNV. Risk factors included posterior uveitis in general and specific uveitis syndromes affecting the outer retina/retinal pigment epithelium (RPE)/choroid interface. Among the 2,364 eyes (1,357 patients) with posterior or panuveitis and free of CNV at the time of cohort entry, the cumulative two-year incidence of CNV was 2.7% (95% confidence interval (95%CI): 1.8-3.5%). Risk factors for incident CNV included currently active inflammation (adjusted HR [aHR] 2.13, 95%CI: 1.26-3.60), preretinal neovascularization (aHR 3.19, 95%CI: 1.30-7.80), and prior diagnosis of CNV in the contralateral eye (aHR 5.79, 95%CI: 2.77-12.09). Among specific syndromes, the incidence was greater in Vogt-Koyanagi-Harada Syndrome (aHR 3.37, 95%CI: 1.52-7.46), and punctate inner choroiditis (aHR 8.67, 95%CI: 2.83-26.54). Incident CNV was associated with two lines’ loss of visual acuity (+0.19 logMAR units, 95%CI: 0.079–0.29) from the preceding visit. Conclusions CNV is an uncommon complication of uveitis associated with visual impairment, which more commonly occurs in forms affecting the outer retina/RPE/choroid interface, during periods of inflammatory activity, in association with preretinal neovascularization, and in second eyes of patients with unilateral CNV. Because CNV is treatable, a systematic approach to early detection in high-risk patients may be appropriate.

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“…Fluorescein angiography (FA) was performed to rule out macular edema in doubtful cases. Macular edema was defined as a macular thickness greater than 250 µm with the presence of intraretinal cysts demonstrated by OCT [20], and/or the presence of retinal angiographic leakage in the central macula area for those patients in which FA was performed.…”

Section: Methodsmentioning

confidence: 99%

Two Functional Variants of IRF5 Influence the Development of Macular Edema in Patients with Non-Anterior Uveitis

et al. 2013

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ObjectiveInterferon (IFN) signaling plays a crucial role in autoimmunity. Genetic variation in interferon regulatory factor 5 (IRF5), a major regulator of the type I interferon induction, has been associated with risk of developing several autoimmune diseases. In the current study we aimed to evaluate whether three sets of correlated IRF5 genetic variants, independently associated with SLE and with different functional roles, are involved in uveitis susceptibility and its clinical subphenotypes.MethodsThree IRF5 polymorphisms, rs2004640, rs2070197 and rs10954213, representative of each group, were genotyped using TaqMan® allelic discrimination assays in a total of 263 non-anterior uveitis patients and 724 healthy controls of Spanish origin.ResultsA clear association between two of the three analyzed genetic variants, rs2004640 and rs10954213, and the absence of macular edema was observed in the case/control analysis (P FDR=5.07E-03, OR=1.48, CI 95%=1.14-1.92 and P FDR=3.37E-03, OR=1.54, CI 95%=1.19-2.01, respectively). Consistently, the subphenotype analysis accordingly with the presence/absence of this clinical condition also reached statistical significance (rs2004640: P=0.037, OR=0.69, CI 95%=0.48-0.98; rs10954213: P=0.030, OR=0.67, CI 95%=0.47-0.96), thus suggesting that both IRF5 genetic variants are specifically associated with the lack of macular edema in uveitis patients.ConclusionOur results clearly showed for the first time that two functional genetic variants of IRF5 may play a role in the development of macular edema in non-anterior uveitis patients. Identifying genetic markers for macular edema could lead to the possibility of developing novel treatments or preventive therapies.

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Uveitic Foveal Atrophy

Cited by 34 publications

References 35 publications

Cystoid Macular Edema in Uveitis

Cystoid Macular Edema in Uveitis

Risk of Choroidal Neovascularization among the Uveitides

Two Functional Variants of IRF5 Influence the Development of Macular Edema in Patients with Non-Anterior Uveitis

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