Uveitis and Pregnancy

Intraocular pressure variation in pregnancy: a prospective study

“…This result in a gradual, statistically significant fall of the IOP during pregnancy. [6][7][8][9] Progesterone has glucocorticoid antagonistic properties and this antagonistic action helps in the lowering of the IOP. The changes in the aqueous dynamics are consistent with the hypothesis that excess progesterone, during pregnancy, blocks the ocular hypertensive effect of endogenous corticosteroids.…”

“…Likewise an increase in corneal thickness could also affect the measured values of IOP. [8][9][10][11][12][13] Aqueous humour formation & its production remained stable, whereas IOP decreased throughout the trimesters and returned to normal levels at 3 months postpartum. Proposed mechanisms underlying the decrease in IOP during pregnancy indicate an association between female hormones and increased outflow.…”