Uveitis and systemic disease.

Abstract

A prospective study was conducted of 865 patients with uveitis to determine the frequency of associated systemic diseases and to assess the value of limited laboratory screening of these patients. All patients underwent a standard diagnostic protocol followed -when indicated -by special tests and procedures performed in order of likelihood ('tailored approach'). For 628 patients (73%) a specific diagnosis was established based on history, ophthalmologic examination, and laboratory and radiographic studies. A definite association with systemic disease was determined for 220 patients (26%). A relationship with a subclinical systemic disorder could be presumed in 201 cases (23%) and a well-established clinical uveitis entity without a recognisable systemic disorder was present in 207 cases (24%). For 237 patients (27%) a diagnosis could not be determined. The most frequently observed systemic diseases were sarcoidosis (7%) and HLA-B27-associated seronegative spondylarthropathies (6%). Presumed or definite toxoplasmosis was encountered in 10% of cases. HLA-B27-associated acute anterior uveitis was the most common clinical entity (17%). In the majority of cases the presence of a systemic disease was not suspected prior to eye involvement and was only recognised after the subsequent diagnostic procedures.

Pattern of uveitis in a referral centre in Tunisia, North Africa

“…Our percentage (1.7%) was similar to that reported in previous studies, 10,12 but lower than that found in others. 15,39 This discrepancy might be explained by racial and geographic factors, and also by a variable difficulty in diagnosing sarcoidosis.…”

Uveítes anteriores associadas a doenças sistêmicas

“…As manifestações oculares incluem nódulos palpebrais e conjuntivais, uveíte anterior granulomatosa, uveíte posterior, retinite, neuropatia óptica e dacrioadenite. É responsável por 10 a 20% de todas as uveítes (8) .…”

Molecular Signaling and Ocular Inflammation: An Update on the NOD-Like Receptors (NLRs)

“…autoimmune), drug-induced, or trauma-related. In all cases, uveitis is believed to be immune-mediated and results from aberrant control of the immune system [9][10][11][12]. Consistent with the autoimmune or autoinflammatory basis for uveitis, it is one of the most clinically important manifestations in a number of systemic immunological disorders including ankylosing spondylitis, Behçet's disease, sarcoidosis, and inflammatory bowel disease [5].…”